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The expression of DUSP1 gene is induced in human skin fibroblasts by oxidative/heat stress and growth factors. 再加上，我们可以发DUSP1 试剂盒 (27) 和 DUSP1 蛋白 (5)和数多这个蛋白质的别的产品。
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Human Polyclonal DUSP1 Primary Antibody for EIA, WB - ABIN360822
Wu, Pew, Zou, Pang, Conzen: Glucocorticoid receptor-induced MAPK phosphatase-1 (MPK-1) expression inhibits paclitaxel-associated MAPK activation and contributes to breast cancer cell survival. in The Journal of biological chemistry 2005
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Human Polyclonal DUSP1 Primary Antibody for IF (p), IHC (p) - ABIN735368
Kato, Naiki-Ito, Naiki, Suzuki, Yamashita, Sato, Sagawa, Kato, Kuno, Takahashi: Connexin 32 dysfunction promotes ethanol-related hepatocarcinogenesis via activation of Dusp1-Erk axis. in Oncotarget 2016
Show all 2 references for ABIN735368
Human Polyclonal DUSP1 Primary Antibody for IF (p) - ABIN894519
Khadir, Tiss, Abubaker, Abufarha, Al-Khairi, Cherian, John, Kavalakatt, Warsame, Al-Madhoun, Al-Ghimlas, Elkum, Behbehani, Dermime, Dehbi: MAP kinase phosphatase DUSP1 is overexpressed in human obese and modulated by physical activity. in American journal of physiology. Endocrinology and metabolism 2014
Human Polyclonal DUSP1 Primary Antibody for IHC (p), IHC - ABIN257653
Alessi, Smythe, Keyse: The human CL100 gene encodes a Tyr/Thr-protein phosphatase which potently and specifically inactivates MAP kinase and suppresses its activation by oncogenic ras in Xenopus oocyte extracts. in Oncogene 1993
Human Polyclonal DUSP1 Primary Antibody for IHC, ELISA - ABIN1532716
Keyse, Emslie: Oxidative stress and heat shock induce a human gene encoding a protein-tyrosine phosphatase. in Nature 1992
Our results emphasize the importance of MKP-1 as a potential predictive biomarker for a subset of breast cancer patients with worse outcome and less susceptibility to treatment.
Collectively, these data indicated that DUSP1 may induce the resistance against paclitaxel through the p38 MAPK (显示 MAPK14 抗体)-mediated overexpression of p-glycoprotein in human ovarian cancer cells.
silencing of IL1B (显示 IL1B 抗体) plus dexamethasone-induced DUSP1 significantly reduced IRF1 (显示 IRF1 抗体) expression. IL1B (显示 IL1B 抗体)-induced expression of CXCL10 (显示 CXCL10 抗体) was largely insensitive to dexamethasone, whereas other DUSP1-enhanced, IRF1 (显示 IRF1 抗体)-dependent mRNAs showed various degrees of repression.
dexamethasone-induced DUSP1 acts via p38 MAPK (显示 MAPK14 抗体) to switch on the mRNA destabilizing function of protein-tristetraprolin (显示 ZFP36 抗体) to repress pro-inflammatory cytokine secretion from ASM (显示 SMPD1 抗体) cells
LPS (显示 IRF6 抗体) tolerance interferes with TLR4 (显示 TLR4 抗体) signaling by inhibiting Lyn (显示 LYN 抗体) and c-Src (显示 SRC 抗体) phosphorylation and their recruitment to TLR4 (显示 TLR4 抗体), while increasing the phosphatase activity and expression of PP2A (显示 PPP2R4 抗体), PTPN22 (显示 PTPN22 抗体), PTP1B (显示 PTPN1 抗体) and MKP1.
This study shows that RIG-I (显示 DDX58 抗体) activation results in MKP-1-mediated inhibition of cell proliferation in melanoma cells via controlling the p38 (显示 CRK 抗体)-HSP27 (显示 HSPB1 抗体), c-Jun (显示 JUN 抗体) and rpS6 (显示 RPS6 抗体) pathways
In E1a (显示 BCKDHA 抗体) expressing non-small cell lung carcinoma cells, upregulation of MKP1 and the subsequent p38MAPK (显示 MAPK14 抗体) inhibition is required for the induction of chemosensitivity to cisplatin.
The heparin effects on TNFalpha (显示 TNF 抗体)-induced stress fiber formation and Map kinase (显示 MAPK1 抗体) signaling depend on increased DUSP1 expression.
evidence of association between depressive symptom severity and increasing serum MKP-1 levels in women, and decreasing T levels in perimenopausal women.
MKP-1 can attenuate tamoxifen-induced cell death through inhibiting the JNK (显示 MAPK8 抗体) signal pathway.
PTHrP (显示 PTHLH 抗体) counteracts the pro-apoptotic actions of reactive oxygen species by a mechanism dependent on MKP1-induced dephosphorylation.
A2AR (显示 ADORA2A 抗体) signaling regulates both basal and LPS (显示 TLR4 抗体)-induced DUSP1 levels in macrophages via activating the adenylate cyclase pathway.
these data suggest an important role for DUSPs in regulating MAPK (显示 MAPK1 抗体) dephosphorylation, with an emphasis on DUSP1, during early adipogenesis
Loss of DUSP1 does not cause changes in cartilage degeneration and gait in a mouse model of spontaneous osteoarthritis at 21 months of age.
Nr4a1 (显示 NR4A1 抗体) induction is dependent on ERK1/2 (显示 MAPK1/3 抗体) and that MKP-1 negatively regulates this induction.
MKP-1 negatively regulates chemokine (显示 CCL1 抗体)-driven osteoclast formation and subsequent bone resorption in response to LPS (显示 TLR4 抗体) stimulation
results suggest that the p38alpha (显示 MAPK14 抗体)-MKP-1 signaling axis links IL-17R signaling in tissue-resident cells to autoimmune inflammation dependent on infiltrating T(H)17 cells.
DUSP1 and tristetraprolin (显示 ZFP36 抗体) cooperate to regulate macrophage responses to lipopolysaccharide.
MKP-1 regulated the expression of MMP-12 (显示 MMP12 抗体).
CYLD (显示 CYLD 抗体) negatively regulates nontypeable Haemophilus influenzae-induced IL-8 (显示 IL8 抗体) expression via MKP-1-dependent inhibition of ERK (显示 EPHB2 抗体).
MKP-1 is the specific phosphatase induced by AngII and involved in the negative feedback mechanism ensuring adequate ERK1/2 (显示 MAPK1/3 抗体)-mediated aldosterone production in response to the hormone.
Agonist stimulation of vascular smooth muscle increases PKC (显示 FYN 抗体) activity, which, in turn, increases MKP-1 activity and maintains MAPK1 (显示 MAPK1 抗体) activity at submaximal values.
The expression of DUSP1 gene is induced in human skin fibroblasts by oxidative/heat stress and growth factors. It specifies a protein with structural features similar to members of the non-receptor-type protein-tyrosine phosphatase family, and which has significant amino-acid sequence similarity to a Tyr/Ser-protein phosphatase encoded by the late gene H1 of vaccinia virus. The bacterially expressed and purified DUSP1 protein has intrinsic phosphatase activity, and specifically inactivates mitogen-activated protein (MAP) kinase in vitro by the concomitant dephosphorylation of both its phosphothreonine and phosphotyrosine residues. Furthermore, it suppresses the activation of MAP kinase by oncogenic ras in extracts of Xenopus oocytes. Thus, DUSP1 may play an important role in the human cellular response to environmental stress as well as in the negative regulation of cellular proliferation.
dual specificity protein phosphatase 1
, dual specificity phosphatase 1
, MAP kinase phosphatase 1
, dual specificity protein phosphatase hVH1
, mitogen-activated protein kinase phosphatase 1
, protein-tyrosine phosphatase CL100
, serine/threonine specific protein phosphatase
, mitogen-activated protein kinase phosphatase-1
, protein tyrosine phosphatase, non-receptor type 16
, protein-tyrosine phosphatase 3CH134
, protein-tyrosine phosphatase ERP
, 3CH134/CL100 PTPase
, MAP kinase phosphatase-1
, mitogen-activated protein (MAP) kinase phosphatase-1
, oxidative stress-inducible protein tyrosine phosphatase
, protein tyrosine phosphatase non-receptor type 16
, protein-tyrosine phosphatase non-receptor type 16
, MAPK phosphatase 1