anti-Dihydrolipoyl Transacetylase (DLAT) 抗体

DLAT encodes component E2 of the multi-enzyme pyruvate dehydrogenase complex (PDC). 再加上,我们可以发Dihydrolipoyl Transacetylase 试剂盒 (10)Dihydrolipoyl Transacetylase 蛋白 (10)和数多这个蛋白质的别的产品。

列出全部抗体 基因 基因ID UniProt
DLAT 1737 P10515
DLAT 81654 P08461
DLAT 235339 Q8BMF4

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Showing 10 out of 56 products:

产品编号 适用 宿主 标记 应用范围 图像 规格 供应商 交付 价格 详细
非结合性 WB <b>WB Suggested Anti-DLAT Antibody Titration: </b>0.2-1 ug/ml<br><b>ELISA Titer: </b>1:62500<br><b>Positive Control: </b>HepG2 cell lysate WB Suggested Anti-DLAT <br /> Antibody Titration: 0.2-1 µg/mL ELISA Titer: 1:.2500 <br /> Positive Control: HepG2 cell lysate <br /> DLAT is strongly supported by BioGPS gene expression data to be expressed in Human HepG2 cells 100 μL Log in to see 5至7个工作日
¥20,898.73
详细
Cow 非结合性 IHC, WB <b>WB Suggested Anti-DLAT Antibody Titration: </b>5.0ug/ml<br><b>Positive Control: </b>Jurkat cell lysate <b>Sample Type</b>: Huh7 lysate (50ug)<br><b>Primary Antibody Dilution</b>: 1:200<br><b>Image Submitted By</b>: Partha Kasturi<br>University of Kansas Medical Center 100 μL Log in to see 5至7个工作日
¥16,831.21
详细
Cow 非结合性 IHC (p), WB 100 μg Log in to see 29至35个工作日
¥4,989.82
详细
Bat 非结合性 WB 50 μg Log in to see 29至35个工作日
¥5,538.93
详细
非结合性 FACS, IHC (p), WB DLAT Antibody (C-term) (ABIN651534) western blot analysis in K562,HepG2,Jurkat cell line lysates (35 µg/lane). This demonstrates the DLAT antibody detected the DLAT protein (arrow). DLAT Antibody (C-term) (ABIN651534) immunohistochemistry analysis in formalin fixed and paraffin embedded human hepatocarcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining 400 μL Log in to see 5至8个工作日
¥2,325.14
详细
非结合性 ICC, IHC, IP, WB 100 μg Log in to see 7至10个工作日
¥1,616.24
详细
小鼠 非结合性 ICC, IHC, IP, WB 100 μg Log in to see 7至10个工作日
¥1,655.08
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非结合性 IHC, ELISA, WB 100 μg Log in to see 24至29个工作日
¥3,531.31
详细
小鼠 非结合性 ICC, IP, WB   100 μL Log in to see 6至8个工作日
¥1,633.54
详细
非结合性 IC, IF, WB Immunofluorescent analysis of PDC-E2 staining in Hela cells. Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with the primary antibody Western blot analysis of PDC-E2 expression in HepG2 (A), Jurkat (B), mouse heart (C), rat brain (D), rat kidney (E) whole cell lysates. 200 μL Log in to see 7至8个工作日
¥3,981.76
详细

通过反应活性、应用领域、克隆类型和共轭标记 DLAT 抗体

特性 应用范围 宿主 克隆类型 标记
Human
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Rat (Rattus)
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Mouse (Murine)


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更多抗Dihydrolipoyl Transacetylase的相互作用对抗体

Human Dihydrolipoyl Transacetylase (DLAT) interaction partners

  1. DLAT interacts with C1QBP (显示 C1QBP 抗体) in mitochondria.

  2. ongoing activation of PDCE2-specific B-cells in primary biliary cirrhosis

  3. Results show that DLAT and ACAT2 (显示 ACAT2 抗体) as upstream acetyltransferases of K76 and K294 in 6PGD (显示 PGD 抗体) protein.

  4. These findings were used to identify potentially antigenic sequences within PDC-E2 (an important hepatic autoantigen) that contain a DR0801 motif.

  5. Solution structure and characterisation of the human pyruvate dehydrogenase (显示 PDP 抗体) complex core assembly

  6. Data suggest that the catalytic site of pyruvate dehydrogenase (显示 PDP 抗体) complex E2 rather than the previously reported lipoyl binding peptide (显示 HP 抗体) may contain immunodominant epitopes recognized by antimitochondrial antibodies in primary biliary cirrhosis.

  7. a novel HLA-A*0201-restricted epitope PDC-E2 165 to 174 was defined in patients with primary biliary cirrhosis.

  8. study of facilitated interaction between the pyruvate dehydrogenase kinase isoform 2 and the dihydrolipoyl acetyltransferase

  9. model of the pyruvate dehydrogenase (显示 PDP 抗体) complex formed by E2 and E2 plus the E3-binding protein (显示 PDHX 抗体) and binding of the E1 and E3 components

  10. Having found that there is an excellent and almost unique match between the PDC-E2 autoepitope and a sequence in mycobacterial hsp65s, we tested the corresponding peptides for cross-reactivity using sera from 90 Spanish and British PBC patients.

Zebrafish Dihydrolipoyl Transacetylase (DLAT) interaction partners

  1. Deficiency of dihydrolipoamide S-acetyltransferase (Dlat) results in neurological dysfunction, congenital lactic acidosis, growth retardation, and early death.

Mouse (Murine) Dihydrolipoyl Transacetylase (DLAT) interaction partners

  1. breach of tolerance to PDC-E2 is probably the first event in the natural history of primary biliary cirrhosis in genetically susceptible hosts.

  2. a novel function of pyruvate dehydrogenase (显示 PDP 抗体) complex E2 in the nucleus in up-regulating the transactivating ability of STAT5 (显示 STAT5A 抗体)

Dihydrolipoyl Transacetylase (DLAT) 抗原简介

蛋白简介

This gene encodes component E2 of the multi-enzyme pyruvate dehydrogenase complex (PDC). PDC resides in the inner mitochondrial membrane and catalyzes the conversion of pyruvate to acetyl coenzyme A. The protein product of this gene, dihydrolipoamide acetyltransferase, accepts acetyl groups formed by the oxidative decarboxylation of pyruvate and transfers them to coenzyme A. Dihydrolipoamide acetyltransferase is the antigen for antimitochondrial antibodies. These autoantibodies are present in nearly 95% of patients with the autoimmune liver disease primary biliary cirrhosis (PBC). In PBC, activated T lymphocytes attack and destroy epithelial cells in the bile duct where this protein is abnormally distributed and overexpressed. PBC enventually leads to cirrhosis and liver failure. Mutations in this gene are also a cause of pyruvate dehydrogenase E2 deficiency which causes primary lactic acidosis in infancy and early childhood.

Gene names and symbols associated with DLAT

  • CG5261 gene product from transcript CG5261-RB (CG5261) 抗体
  • dihydrolipoamide S-acetyltransferase (dlat) 抗体
  • dihydrolipoamide S-acetyltransferase (DLAT) 抗体
  • dihydrolipoamide S-acetyltransferase (Dlat) 抗体
  • dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex) (dlat) 抗体
  • dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex) (Dlat) 抗体
  • 6332404G05Rik 抗体
  • anon-WO0118547.121 抗体
  • DLAT 抗体
  • DLTA 抗体
  • Dmel\\CG5261 抗体
  • EP(2)0816 抗体
  • EP816 抗体
  • PDC-E2 抗体
  • PDCE2 抗体
  • wu:fc14f10 抗体
  • wu:fc21f08 抗体
  • wu:fc86g11 抗体
  • wu:fj57d06 抗体

Protein level used designations for DLAT

CG5261-PA , CG5261-PB , CG5261-PC , CG5261-PD , CG5261-PE , CG5261-PF , Dihydrolipoyllysine-residue acetyltransferase , dihydrolipoamide acetyltransferase , dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex) , 70 kDa mitochondrial autoantigen of primary biliary cirrhosis , E2 component of pyruvate dehydrogenase complex , M2 antigen complex 70 kDa subunit , PBC , dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex , dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex mitochondrial , dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial , pyruvate dehydrogenase complex component E2 , dihydrolipoyllysine-residue acetyltransferase , E2 , PDC-E2 , PDCE2 , fc86g11 , fj57d06 , no optokinetic nystagmus a , no optokinetic response b , noa , nrb

GENE ID SPECIES
34021 Drosophila melanogaster
398314 Xenopus laevis
419796 Gallus gallus
1737 Homo sapiens
489406 Canis lupus familiaris
397054 Sus scrofa
512723 Bos taurus
81654 Rattus norvegicus
100349212 Oryctolagus cuniculus
324201 Danio rerio
235339 Mus musculus
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