Diacylglycerol Kinase, alpha 80kDa 蛋白 (DGKA)

The protein encoded by DGKA belongs to the eukaryotic diacylglycerol kinase family. 再加上,我们可以发DGKA 抗体 (113)DGKA 试剂盒 (10)和数多这个蛋白质的别的产品。

列出全部蛋白 基因 基因ID UniProt
DGKA 13139 O88673
DGKA 140866 P51556
DGKA 1606 P23743

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产品编号 Origin 资源 标记 图像 规格 供应商 交付 价格 详细
Insect Cells His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 78至87个工作日
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Insect Cells 小鼠 His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 88至92个工作日
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大肠杆菌(E. Coli) 小鼠 His tag,T7 tag 100 μg Log in to see 9至12个工作日
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小麦胚 GST tag 10 μg Log in to see 29至34个工作日
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HOST_HEK-293 Cells Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 28至34个工作日
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酵母菌 大鼠 His tag   1 mg Log in to see 24至35个工作日
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大肠杆菌(E. Coli) 大鼠 His tag,T7 tag 100 μg Log in to see 9至12个工作日
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大肠杆菌(E. Coli) 小鼠 非结合性   100 μg Log in to see 29至40个工作日
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DGKA 蛋白 by Origin and Source

Origin 在表达 标记
Mouse (Murine) ,
,
Rat (Rattus) ,
,
Human , ,
, ,

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Mouse (Murine) Diacylglycerol Kinase, alpha 80kDa (DGKA) interaction partners

  1. Our studies demonstrate that PKD1 (显示 PKD1 蛋白)/2 is a key regulator of MVB maturation and exosome secretion, and constitutes a mediator of the DGK alpha effect on MVB secretory traffic.

  2. Diacylglycerol kinase alpha establishes T cell polarity by shaping diacylglycerol accumulation at the immunological synapse.

  3. Ovalbumin (显示 OVA 蛋白)-induced airway inflammation was inhibited after DGKalpha DNA vaccine administation.

  4. Data indicate that combined deletion of dgkzeta (显示 DGKZ 蛋白) and dgkalpha markedly enhances T-cell responses.

  5. The data strongly supported a role for FoxO (显示 FOXO3 蛋白) proteins in promoting high diacylglycerol kinase alpha levels and indicate a mechanism by which diacylglycerol kinase alpha function is downregulated during productive T cell responses.

  6. results suggest that the globular form of adiponectin (显示 ADIPOQ 蛋白)-induced generation of reactive oxygen species and nitric oxide involves diacylglycerol kinase alpha

  7. DAG kinases (DGKs) alpha and zeta, which terminate DAG-mediated signaling, synergistically inhibit TCR-induced mTOR (显示 FRAP1 蛋白) activation by inhibiting the Ras-Mek1 (显示 MAP2K1 蛋白)/2-Erk (显示 EPHB2 蛋白)/12 pathway

  8. A role for DGK alpha in T cell activation is confirmed by the rapid DGK alpha translocation to the membrane fraction, together with the increase in enzyme activity that follows T cell activation in vivo.

  9. regulated by pi 3 (显示 PI3 蛋白)-kinase activation products

  10. Diacylglycerol kinase alpha is an anergy-associated molecule that negatively regulates Ras in anergic T cells.

Human Diacylglycerol Kinase, alpha 80kDa (DGKA) interaction partners

  1. An abandoned compound that also inhibits serotonin receptors may have more translational potential as a DGKa inhibitor, but more potent and specific DGKa inhibitors are sorely needed

  2. Decreased DNA methylation (显示 HELLS 蛋白) at this enhancer enables recruitment of the profibrotic transcription factor early growth response 1 (EGR1 (显示 EGR1 蛋白)) and facilitates radiation-induced DGKA transcription in cells from patients later developing fibrosis.

  3. These data indicates the existence of a SDF-1alpha induced DGKalpha - atypical PKC - beta1 integrin signaling pathway, which is essential for matrix invasion of carcinoma cells.

  4. DGKalpha generates phosphatidic acid to drive its own recruitment to tubular recycling endosomes via its interaction with MICAL-L1 (显示 MICALL1 蛋白)

  5. High diacylglycerol kinase alpha expression is associated with glioblastoma.

  6. DGKalpha is involved in hepatocellular carcinoma progression by activation of the MAPK (显示 MAPK1 蛋白) pathway.

  7. DGK-alpha was more highly expressed in CD8 (显示 CD8A 蛋白)-tumor-infiltrating T cellscompared with that in CD8non-tumor kidney-infiltrating lymphocytes.

  8. Antigen-specific CD8 (显示 CD8A 蛋白)-positive T cells from DGKalpha-deficient transgenic mice show enhanced expansion and increased cytokine production after lymphocytic choriomeningitis virus infection, yet DGK (显示 DGKB 蛋白)-deficient memory CD8 (显示 CD8A 蛋白)+ T cells exhibit impaired expansion.

  9. SAP (显示 APCS 蛋白)-mediated inhibition of DGKalpha sustains diacylglycerol signaling, thereby regulating T cell activation

  10. Diacylglycerol kinase alpha is a key regulator of the polarised secretion of exosomes.

Pig (Porcine) Diacylglycerol Kinase, alpha 80kDa (DGKA) interaction partners

  1. the nucleo-cytoplasmic shuttling of DGKalpha is orchestrated by tyrosine phosphorylation by the Src-activated tyrosine kinase c-Abl

蛋白简介DGKA

蛋白简介

The protein encoded by this gene belongs to the eukaryotic diacylglycerol kinase family. It acts as a modulator that competes with protein kinase C for the second messenger diacylglycerol in intracellular signaling pathways. It also plays an important role in the resynthesis of phosphatidylinositols and phosphorylating diacylglycerol to phosphatidic acid. Alternative splicing occurs at this locus and four transcript variants encoding the same protein have been identified.

Gene names and symbols associated with DGKA

  • diacylglycerol kinase, alpha 80kDa (DGKA)
  • diacylglycerol kinase, alpha 80kDa (dgka)
  • diacylglycerol kinase, alpha a (dgkaa)
  • diacylglycerol kinase alpha (Tsp_02164)
  • diacylglycerol kinase, alpha (Dgka)
  • 80kDa 蛋白
  • AW146112 蛋白
  • DAGK 蛋白
  • DAGK1 蛋白
  • DGK-alpha 蛋白
  • dgka 蛋白
  • zgc:136759 蛋白

Protein level used designations for DGKA

diacylglycerol kinase, alpha 80kDa , diacylglycerol kinase alpha , diacylglycerol kinase alpha-like , 80 kDa diacylglycerol kinase , DAG kinase alpha , DGK-alpha , diacylglycerol kinase alpha Flt2-Pr2 , diglyceride kinase alpha , truncated diacylglycerol kinase alpha Flt1-Pr1

GENE ID SPECIES
451976 Pan troglodytes
564739 Danio rerio
710559 Macaca mulatta
724010 Danio rerio
10907457 Trichinella spiralis
100124931 Xenopus (Silurana) tropicalis
100172456 Pongo abelii
100347223 Oryctolagus cuniculus
100380983 Xenopus laevis
100405635 Callithrix jacchus
100593934 Nomascus leucogenys
13139 Mus musculus
140866 Rattus norvegicus
1606 Homo sapiens
506348 Bos taurus
397097 Sus scrofa
474393 Canis lupus familiaris
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