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DPPA3 encodes a protein that in mice may function as a maternal factor during the preimplantation stage of development. 再加上，我们可以发DPPA3 抗体 (19) 和 DPPA3 蛋白 (6)和数多这个蛋白质的别的产品。
DPPA3 is a maternal factor (显示 ZAR1 ELISA试剂盒) important for correct epigenetic remodeling and normal embryonic development in cattle, indicating that the role of DPPA3 during early development is conserved between species.
Data suggest enforced expression of Stella into normal cells induces not only global DNA demethylation but also neoplastic transformation and increases metastatic ability; these changes involve altered regulation of neoplastic gene expression.
Considering that impaired DNA methylation (显示 HELLS ELISA试剂盒) profiles are associated with various developmental or disease phenomena, Stella may be a powerful tool with which to study the biological effects of global DNA hypomethylation
a role for STELLA in facilitating germline and endodermal differentiation of human ES cells
human adult tissue-specific transcripts originate via retrotransposition of the pluripotent cell-specific gene, Dppa3
These results demonstrate that PGC7/Stella is indispensable for the maintenance of methylation involved in epigenetic reprogramming after fertilization.
In mice, a targeted mutation results in reduced female fertility and (显示 MTA2 ELISA试剂盒)may function as a mammalian maternal effect gene.
In mice, knockout experiments show this gene may be a maternal factor (显示 ZAR1 ELISA试剂盒) in cleavage stage embryogenesis.
This study shows repression of the Dppa3 Locus in the absence of MAD2L2 (显示 MAD2L2 ELISA试剂盒) embryonic stem cells.
In-depth transcriptome analysis of this mESC state reveals Dppa3 as a direct downstream target of Tbx3 (显示 TBX3 ELISA试剂盒).We show that Tbx3 (显示 TBX3 ELISA试剂盒), a downstream target of Wnt (显示 WNT2 ELISA试剂盒) signaling, fine tunes these divergent roles of Wnt (显示 WNT2 ELISA试剂盒) signaling in mESCs
Dppa3 has a critical role in generation of fully reprogrammed iPS (显示 SLC27A4 ELISA试剂盒) cells and maintenance of Dlk1 (显示 DLK1 ELISA试剂盒)-Dio3 (显示 DIO3 ELISA试剂盒) imprinting
Stella protects maternal chromosomes from aberrant epigenetic modifications to ensure early embryogenesis.
Chromocenter formation is impaired in Stella-null embryos.
we propose that Dppa3 is involved in the Tet-mediated active demethylation process during reprogramming of primordial germ cells.
PGC7 protects 5mC from Tet3 (显示 TET3 ELISA试剂盒)-mediated conversion to 5hmC by binding to maternal chromatin containing dimethylated histone H3 (显示 HIST3H3 ELISA试剂盒) lysine 9 (H3K9me2) in mice
These Dppa3-MCM strains offer valuable opportunities to explore gene function in both loss-of-function and gain-of-function experiments at a variety of time points during germ cell development.
DPPA3 is an essential factor for the production of functional oocytes through transcriptional repression and chromatin condensation.
Data show that STELLA was found in both the nucleus and cytoplasm in a variety of cell types, both within and outside of the putative primordial germ cells (PGCs)trajectory.
This gene encodes a protein that in mice may function as a maternal factor during the preimplantation stage of development. In mice, this gene may play a role in transcriptional repression, cell division, and maintenance of cell pluripotentiality. In humans, related intronless loci are located on chromosomes 14 and X.
developmental pluripotency-associated protein 3
, stella-related protein
, developmental pluripotency associated 3
, compaction-associated protein 1
, primordial germ cell 7
, primordial germ cell protein 7