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DES encodes a muscle-specific class III intermediate filament. 再加上，我们可以发Desmin 抗体 (388) 和 Desmin 蛋白 (27)和数多这个蛋白质的别的产品。
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Human Desmin ELISA Kit for Sandwich ELISA - ABIN417384
Kobayashi, Olson, Sly, Swanson, Chung, Naryshkin, Narasimhan, Bhattacharyya, Mullenix, Chen: Utility of survival motor neuron ELISA for spinal muscular atrophy clinical and preclinical analyses. in PLoS ONE 2011
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Desmin intermediate filaments are required for normal active force generation.
Desmin distribution during muscle maturation changes from dispersed aggregates to a perinuclear concentration to striated (显示 NSDHL ELISA试剂盒) afterwards.
Cdk1 (显示 CDK1 ELISA试剂盒)-induced desmin phosphorylation is required for efficient separation of desmin-IFs and generally detected in muscular mitotic cells in vivo.
Desmin, Lamin A/C, MMP9, and histone H4 were upregulated in the placental villi of women experiencing early pregnancy loss.
Increasing desmin abnormalities were correlated with diastolic dysfunction progression.
expression level of mutant versus wild-type desmin in mouse model as well as in skeletal muscle specimens derived from human R350P desminopathies; findings demonstrate missense-mutant desmin inflicts changes of the subcellular localization and turnover of desmin itself and of direct desmin-binding partners
Results propose that the mutations affect desmin structure and cause its aberrant folding and subsequent aggregation, triggering disruption of myofibrils organization.
identified disruption of the desmin system in gastrocnemius myofibers as an index of the myopathy and limitation of muscle function in patients with peripheral artery disease.
The desmin intermediate filament network plays a major role in striated (显示 NSDHL ELISA试剂盒) muscle development and maintenance by integrating and coordinating most cellular components necessary for proper mechanochemical signaling, organelle cross-talk, energy production and trafficking processes required for proper tissue homeostasis. [Review]
Data suggest that loss of the desmin-p. A120D filament localization at the intercalated disk indicates its clinical arrhythmogenic potential.
we describe a new mutation located in the coiled 1B domain of desmin and associated with a predominant cardiac involvement and a high degree of cardiac sudden death in a large Indian pedigree with 12 affected members
Perfomed proteomic analysis on a transgenic mouse model of severe cardiac hypertrophy; compared data to dataset of heart failure found MYH7 (显示 MYH7 ELISA试剂盒), IGFBP7 (显示 IGFBP7 ELISA试剂盒), ANXA2 (显示 ANXA2 ELISA试剂盒), and DESM to be biomarker candidates for heart failure.
Complete lack or markedly decreased expression of mutant R349P desmin impairs the structural and functional integrity of neuromuscular endplates.
the coordinated up-regulations of desmin and alpha- actinin (显示 ACTN1 ELISA试剂盒) specifically in the early stage of diastolic heart failure mouse models indicate a novel myocardial response.
E413K mutation induces desmin network disorganization, desmin aggregate formation and alters the traction forces generation of single myoblasts.
This study identifies desmin as a new Asb2b target for proteasomal degradation in cardiomyocytes and suggests that accumulation of desmin could contribute to UPS impairment in Hypertrophic cardiomyopathy mice and patients
found that inhibition of the Rac1 pathway (a G protein signaling pathway involved in diverse cellular processes), antioxidant treatment, and stimulation of macroautophagy reduced desmin aggregation by up to 75% in this model
This demonstration of biomechanical integration by the desmin intermediate filament system suggests that it plays an active biological role in muscle in addition to its accepted structural role
Disruption of both nesprin 1 (显示 SYNE1 ELISA试剂盒) and desmin results in decreased lifespan, body weight and muscle strength.
Results show that expression of desmin increased during the late fattening stage of of hanwoo steers and it contributes to the muscle contractile apparatus.
This gene encodes a muscle-specific class III intermediate filament. Homopolymers of this protein form a stable intracytoplasmic filamentous network connecting myofibrils to each other and to the plasma membrane. Mutations in this gene are associated with desmin-related myopathy, a familial cardiac and skeletal myopathy (CSM), and with distal myopathies.
, desmin, gene 1
, intermediate filament protein
, muscle-specific intermediate filament desmin