CDT2/RAMP 抗体
(Denticleless E3 Ubiquitin Protein Ligase Homolog (DTL))
Substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control, DNA damage response and translesion DNA synthesis. The DCX(DTL) complex, also named CRL4(CDT2) complex, mediates the polyubiquitination and subsequent degradation of CDT1 and CDKN1A/p21(CIP1). CDT1 degradation in response to DNA damage is necessary to ensure proper cell cycle regulation of DNA replication. CDKN1A/p21(CIP1) degradation during S phase or following UV irradiation is essential to control replication licensing. Most substrates require their interaction with PCNA for PIP-box, and those containing the 'K+4' motif in the PIP box, recruit the DCX(DTL) complex, leading to their degradation. In undamaged proliferating cells, the DCX(DTL) complex also promotes the 'Lys-164' monoubiquitination of PCNA, thereby being involved in PCNA-dependent translesion DNA synthesis (By similarity).
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CDT2/RAMP 抗体 by 适用
Find CDT2/RAMP 抗体 for a variety of species such as anti-Human CDT2/RAMP, anti-Mouse CDT2/RAMP, anti-Rat CDT2/RAMP. The species listed below are among those available. Click on a link to go to the corresponding products.
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CDT2/RAMP 抗体 by 标记
Find CDT2/RAMP 抗体 with a specific conjugate such as FITC, Biotin, HRP. The conjugates listed below are among those available. Click on a link to go to the corresponding products.
Popular CDT2/RAMP 抗体
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
ELISA, IHC
Validations
- (2)
Cat. No.
ABIN7149691
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
WB, IF
Validations
- (2)
Cat. No.
ABIN949333
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human, Mouse
Application
WB, FACS, EIA
Validations
- (1)
- (2)
Cat. No.
ABIN951451
Quantity
0.4 mL
Datasheet
Datasheet
Reactivity
Bat, Cow, Dog, Guinea Pig, Horse, Human, Monkey, Mouse, Pig, Rabbit, Rat
Application
WB
Validations
- (1)
Cat. No.
ABIN6738232
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB
Validations
- (1)
Cat. No.
ABIN6139847
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human, Mouse
Application
WB, FACS
Validations
- (2)
Cat. No.
ABIN654926
Quantity
400 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA, IHC (p), IF (cc), IF (p), IHC (fro)
Validations
Cat. No.
ABIN873173
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
ELISA
Validations
Cat. No.
ABIN7149694
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
ELISA
Validations
Cat. No.
ABIN7149692
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human, Mouse
Application
WB, ELISA
Validations
Cat. No.
ABIN6390479
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB, ELISA, IP
Validations
Cat. No.
ABIN7113419
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
IP, IHC (fp)
Validations
Cat. No.
ABIN7454381
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
WB, IP, IHC (fp)
Validations
Cat. No.
ABIN7454696
Quantity
20 μg
Datasheet
Datasheet
Reactivity
Human, Mouse
Application
IHC
Validations
Cat. No.
ABIN7448536
Quantity
20 μg
Datasheet
Datasheet
Latest Publications for our CDT2/RAMP 抗体
: "Tumor suppressor protein Lgl mediates G1 cell cycle arrest at high cell density by forming an Lgl-VprBP-DDB1 complex." in: Molecular biology of the cell, Vol. 26, Issue 13, pp. 2426-38, (2015) (PubMed).: "Overexpression of denticleless E3 ubiquitin protein ligase homolog (DTL) is related to poor outcome in gastric carcinoma." in: Oncotarget, Vol. 6, Issue 34, pp. 36615-24, (2015) (PubMed).
: "Interactions between the otitis media gene, Fbxo11, and p53 in the mouse embryonic lung." in: Disease models & mechanisms, Vol. 8, Issue 12, pp. 1531-42, (2015) (PubMed).
: "Regulation of the CRL4(Cdt2) ubiquitin ligase and cell-cycle exit by the SCF(Fbxo11) ubiquitin ligase." in: Molecular cell, Vol. 49, Issue 6, pp. 1159-66, (2013) (PubMed).
: "SET8 is degraded via PCNA-coupled CRL4(CDT2) ubiquitylation in S phase and after UV irradiation." in: The Journal of cell biology, Vol. 192, Issue 1, pp. 43-54, (2011) (PubMed).
: "Prognostic significance of miR-215 in colon cancer." in: Clinical colorectal cancer, Vol. 10, Issue 4, pp. 340-7, (2011) (PubMed).
: "PCNA-dependent regulation of p21 ubiquitylation and degradation via the CRL4Cdt2 ubiquitin ligase complex." in: Genes & development, Vol. 22, Issue 18, pp. 2496-506, (2008) (PubMed).
Aliases for CDT2/RAMP 抗体
denticleless E3 ubiquitin protein ligase homolog (DTL) 抗体denticleless E3 ubiquitin protein ligase (Dtl) 抗体
denticleless E3 ubiquitin protein ligase homolog (Dtl) 抗体
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