anti-DOT1-Like, Histone H3 Methyltransferase (S. Cerevisiae) (DOT1L) 抗体

The protein encoded by DOT1L is a histone methyltransferase that methylates lysine-79 of histone H3. 再加上,我们可以发DOT1-Like, Histone H3 Methyltransferase (S. Cerevisiae) 蛋白 (5)DOT1-Like, Histone H3 Methyltransferase (S. Cerevisiae) 试剂盒 (4)和数多这个蛋白质的别的产品。

列出全部抗体 基因 基因ID UniProt
DOT1L 84444 Q8TEK3
DOT1L 362831  
DOT1L 208266  

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Showing 10 out of 77 products:

产品编号 适用 宿主 标记 应用范围 图像 规格 供应商 交付 价格 详细
非结合性 ICC, IF, IHC, IHC (p), IP Western Blot: DOT1L Antibody [ABIN251530] - Detection of Human DOT1L by Western Blot of Immunoprecipitates. Samples: Whole cell lysate (1 mg for IP, 20% of IP loaded) from HeLa cells. Antibodies: Affinity purified rabbit anti-DOT1L antibody ABIN251530 used for IP at 3 mcg/mg lysate. DOT1L was also immunoprecipitated by rabbit anti- DOT1L antibody ABIN251529, which recognizes an upstream epitope. Detection: Chemiluminescence with an exposure time 10 seconds. 100 μL Log in to see 25至31个工作日
¥3,977.17
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非结合性 ChIP, ICC, IF, IHC (p), IP, IHC, WB Western Blot and Immunoprecipitation: DOT1L Antibody [ABIN251529] - Detection of Human DOT1L by Western Blot and Immunoprecipitation. Samples: Whole cell lysate (5, 15 and 50 mcg for WB, 1 mg for IP, 20% of IP loaded) from HeLa cells. Antibodies: Affinity purified rabbit anti-DOT1L antibody ABIN251529 used for WB at 0.04 mcg/ml (A) and 1 mcg/ml (B) and used for IP at 3 mcg/mg lysate (B). DOT1L was also immunoprecipitated by another rabbit anti-DOT1L antibody and ABIN251530, which recognizes a downstream epitope. Detection: Chemiluminescence with exposure times of 3 minutes (A) and 10 seconds (B). Immunohistochemistry-Paraffin: DOT1L Antibody [ABIN2515295] - FFPE section of human colon carcinoma.. 0.1 mL Log in to see 25至31个工作日
¥3,977.17
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非结合性 IHC (p) Formalin-fixed and paraffin embedded human kidney labeled with Anti-DOT1L Polyclonal Antibody, Unconjugated  at 1:200 followed by conjugation to the secondary antibody and DAB staining. 100 μL Log in to see 5至7个工作日
¥2,610.23
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非结合性 WB WB Image DOT1L antibody detects DOT1L protein by Western blot analysis. A. H1299 whole cell lysate/extract % SDS-PAGE DOT1L antibody , dilution: 1:1000 100 μL Log in to see 23至28个工作日
¥9,012.09
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HRP IHC (p)   100 μL Log in to see 14至17个工作日
¥3,555.98
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小鼠 非结合性 IHC, WB Immunohistochemistry: DOT1L Antibody (6E7) [NBP2-46474] - Analysis of Carcinoma of Human thyroid tissue. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min) Western Blot: DOT1L Antibody (6E7) [NBP2-46474] - Analysis of HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY DOT1L. 0.1 mL Log in to see 26至33个工作日
¥3,655.56
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非结合性 WB DOT1L antibody (pAb) tested by Western blot. Nuclear extract of HEK293 cells (40 µg per lane) probed with DOT1L antibody (pAb) at a dilution of 1:500. 100 μL Log in to see 23至29个工作日
¥4,264.21
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Biotin IHC (p)   100 μL Log in to see 14至17个工作日
¥3,366.82
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小鼠 非结合性 WB   100 μL Log in to see 29至35个工作日
¥4,989.82
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小鼠 非结合性 IHC (p), WB   100 μL Log in to see 29至35个工作日
¥4,989.82
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通过反应活性、应用领域、克隆类型和共轭标记 DOT1L 抗体

特性 应用范围 宿主 克隆类型 标记
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Mouse (Murine) ,


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引用最多的anti-DOT1-Like, Histone H3 Methyltransferase (S. Cerevisiae) 抗体

  1. Human Polyclonal DOT1L Primary Antibody for ChIP, ICC - ABIN251529 : Steger, Lefterova, Ying, Stonestrom, Schupp, Zhuo, Vakoc, Kim, Chen, Lazar, Blobel, Vakoc: DOT1L/KMT4 recruitment and H3K79 methylation are ubiquitously coupled with gene transcription in mammalian cells. in Molecular and cellular biology 2008 (PubMed)
    Show all 5 references for 251529

  2. Human Polyclonal DOT1L Primary Antibody for ICC, IF - ABIN251530 : Vernimmen, Lynch, De Gobbi, Garrick, Sharpe, Sloane-Stanley, Smith, Higgs: Polycomb eviction as a new distant enhancer function. in Genes & development 2011 (PubMed)

更多抗DOT1-Like, Histone H3 Methyltransferase (S. Cerevisiae)的相互作用对抗体

Human DOT1-Like, Histone H3 Methyltransferase (S. Cerevisiae) (DOT1L) interaction partners

  1. our results identify DOT1L as a novel cofactor in N-Myc (显示 MYCN 抗体)-mediated transcriptional activation of target genes and neuroblastoma (显示 ARHGEF16 抗体) oncogenesis. Furthermore, they characterize DOT1L inhibitors as novel anticancer agents against MYCN (显示 MYCN 抗体)-amplified neuroblastoma (显示 ARHGEF16 抗体).

  2. These results reveal a cooperative transcriptional activation mechanism of AEP (显示 LGMN 抗体) and DOT1L and suggest a molecular rationale for the simultaneous inhibition of the MLL (显示 MLL 抗体) fusion-AF4 complex and DOT1L for more effective treatment of MLL (显示 MLL 抗体)-rearranged leukemia.

  3. this indicates that DOT1L function, like MLL (显示 MLL 抗体), does not completely rely on its methyltransferase activity. Nevertheless, the small molecule DOT1L inhibition is sufficient to block the proliferation of MLL (显示 MLL 抗体) fusion-induced leukemia cells of murine and human origin

  4. DOT1L may play a critical role in DNMT3A (显示 DNMT3A 抗体)-mutant leukemia.

  5. DOT1L, via dimethylated histone H3 (显示 HIST3H3 抗体) K79, facilitates histone H4 acetylation, which in turn regulates the binding of BRD4 (显示 BRD4 抗体) to chromatin in acute lymphoblastic leukemia.

  6. study demonstrates the development of potent DOT1L inhibitors with novel scaffolds

  7. these findings strongly support the contention that histone methyltransferase, DOT1L-associated epigenetic changes induced by HA play pivotal roles in miR-10 (显示 LILRB2 抗体) production leading to up-regulation of RhoGTPase and survival proteins.

  8. Report drug formulation/delivery of DOT1L inhibitor pinometostat in leukemia.

  9. MLL1 and DOT1L cooperate with meningioma-1 to induce acute myeloid leukemia (显示 BCL11A 抗体).

  10. These data converge on a possible mechanism for hDot1L stimulation in which histone H2B physically 'corrals' the enzyme into a productive binding orientation.

Mouse (Murine) DOT1-Like, Histone H3 Methyltransferase (S. Cerevisiae) (DOT1L) interaction partners

  1. These results reveal a cooperative transcriptional activation mechanism of AEP (显示 LGMN 抗体) and DOT1L and suggest a molecular rationale for the simultaneous inhibition of the MLL (显示 MLL 抗体) fusion-AF4 complex and DOT1L for more effective treatment of MLL (显示 MLL 抗体)-rearranged leukemia.

  2. DOT1L may play a critical role in DNMT3A (显示 DNMT3A 抗体)-mutant leukemia.

  3. DOT1L, via dimethylated histone H3 (显示 HIST3H3 抗体) K79, facilitates histone H4 (显示 HIST1H4H 抗体) acetylation, which in turn regulates the binding of BRD4 (显示 BRD4 抗体) to chromatin in acute lymphoblastic leukemia.

  4. Dot1l is a new epigenetic regulator of principal cells and intercalated cell differentiation and Atp6v1b1 (显示 ATP6V1B1 抗体) is a new transcriptional target of Dot1l.

  5. results demonstrate that histone methylation, and in particular DOT1L-mediated H3K79me2 modification, drives cardiomyogenesis through the definition of a specific transcriptional landscape

  6. Interference with DOT1L activity resulted in transcriptional activation of Atf4 (显示 ATF4 抗体) and Ddit3 (显示 DDIT3 抗体) accompanied by decreased levels of H3K79 dimethylation.

  7. MLL1 and DOT1L cooperate with meningioma-1 to induce acute myeloid leukemia (显示 BCL11A 抗体).

  8. DOT1L has a role in inhibiting SIRT1 (显示 SIRT1 抗体)-mediated epigenetic silencing to maintain leukemic gene expression in MLL (显示 MLL 抗体)-rearranged leukemia

  9. Dot1L and H3K79 methylation play important roles in meiosis progression and are supposed to be associated with chromosome deacetylation of mouse oocytes.

  10. Results provide evidence that transformation driven by MLL (显示 MLL 抗体) fusions as well as the recurrent AML (显示 RUNX1 抗体)-associated NUP98 (显示 NUP98 抗体)-NSD1 (显示 NSD1 抗体) fusion oncogene (显示 RAB1A 抗体) is critically dependent on the ability of AF10 (显示 MLLT10 抗体) to stimulate DOT1L activity.

DOT1-Like, Histone H3 Methyltransferase (S. Cerevisiae) (DOT1L) 抗原简介

蛋白简介

The protein encoded by this gene is a histone methyltransferase that methylates lysine-79 of histone H3. It is inactive against free core histones, but shows significant histone methyltransferase activity against nucleosomes.

Gene names and symbols associated with DOT1L

  • histone-lysine N-methyltransferase, H3 lysine-79 specific (Dot1l) 抗体
  • DOT1-like, histone H3 methyltransferase (S. cerevisiae) (DOT1L) 抗体
  • C terminus is similar to that of S. cerevisiae DOT1 (YDR440W) nucleosomal histone H3-Lys79 methylase involved in meiosis and transcriptional silencing (DOT1) 抗体
  • DOT1-like histone H3K79 methyltransferase (DOT1L) 抗体
  • DOT1-like histone H3K79 methyltransferase (Dot1l) 抗体
  • DOT1-like, histone H3 methyltransferase (S. cerevisiae) (Dot1l) 抗体
  • A630076O07 抗体
  • AW907654 抗体
  • Dot1 抗体
  • DOT1L 抗体
  • KMT4 抗体
  • mDot1 抗体
  • NV11307 抗体

Protein level used designations for DOT1L

histone-lysine N-methyltransferase, H3 lysine-79 specific , DOT1-like, histone H3 methyltransferase (S. cerevisiae) , histone-lysine N-methyltransferase, H3 lysine-79 specific-like , possible nucleosomal histone methylase , DOT1-like protein , DOT1-like, histone H3 methyltransferase , H3-K79-HMTase , histone H3-K79 methyltransferase , histone methyltransferase DOT1L , lysine N-methyltransferase 4 , DOT1-like histone H3 methyltransferase , histone H3 methyltransferase DOT1

GENE ID SPECIES
100116648 Nasonia vitripennis
420078 Gallus gallus
100068506 Equus caballus
485073 Canis lupus familiaris
710033 Macaca mulatta
100464435 Ailuropoda melanoleuca
100619840 Monodelphis domestica
3642236 Candida albicans SC5314
84444 Homo sapiens
362831 Rattus norvegicus
208266 Mus musculus
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