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DNA (cytosine-5-)-methyltransferase 1 has a role in the establishment and regulation of tissue-specific patterns of methylated cytosine residues. 再加上，我们可以发DNA (Cytosine-5)-Methyltransferase 1 抗体 (489) 和 DNA (Cytosine-5)-Methyltransferase 1 蛋白 (8)和数多这个蛋白质的别的产品。
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Qin, Leonhardt, Pichler: Regulation of DNA methyltransferase 1 by interactions and modifications. in Nucleus (Austin, Tex.) 2011
Dnmt1 stability requires UHRF1 (显示 UHRF1 ELISA试剂盒) phosphorylation and that crosstalk between the proteins is essential for the function of these two important epigenetic regulators during gastrulation
Lsh (显示 HELLS ELISA试剂盒) Is Essential for Maintaining Global DNA Methylation (显示 HELLS ELISA试剂盒) Levels in Amphibia and Fish and Interacts Directly with Dnmt1.
Dnmt1 is required for hematopoietic stem and progenitor cells maintenance via cebpa (显示 CEBPA ELISA试剂盒) regulation during definitive hematopoiesis in zebrafish
These data provide the first evidence that Uhrf1 (显示 UHRF1 ELISA试剂盒) and Dnmt1 function is required for vertebrate lens development and maintenance.
These results suggest that Dnmt1 activity helps direct histone methylation by Suv39h1 (显示 SUV39H1 ELISA试剂盒) and that, together, Dnmt1 and Suv39h1 (显示 SUV39H1 ELISA试剂盒) help guide the terminal differentiation of particular tissues.
Data show that in dnmt1 homozygous mutants, reactivation of gfp expression occurs in a reproducible subset of cells, raising the possibility of different sensitivities or alternative silencing mechanisms in discrete cell populations.
Thus, our data suggest that Dnmt1 is dispensable for pancreatic duct or endocrine cell formation, but not for acinar cell survival. In addition, Dnmt1 may influence the differentiation of pancreatic beta cell progenitors.
AMPK phosphorylates DNMT1, RBBP7, and HAT1 and increases interactions of DNMT1, RBBP7, and HAT1.
Our results highlight a novel role for miR (显示 MLXIP ELISA试剂盒)-377-DNMT1-p53 (显示 TP53 ELISA试剂盒) axis in HSF (显示 HSF1 ELISA试剂盒) senescence. These findings shed new light on the mechanisms of skin aging and identify future opportunities for its therapeutic prevention
The crystal structure of the replication foci targeting sequence (RFTS) of Dnmt1 in complex with H3-K18Ub/23Ub reveals striking differences to the known ubiquitin-recognition structures.
Significantly lower DNMT1 and DNMT3A (显示 DNMT3A ELISA试剂盒) transcript levels in systemic lupus erythematosus patients were observed compared with healthy controls.
The LncRNA-SNHG1 accelerated the proliferation of gastric cancer cells obviously and increased the expression of DNMT1.
the role of DNMT1 at sites of oxidative damage is to reduce transcription, potentially preventing transcription from interfering with the repair process.
these results indicate that DNMT1 mediates aberrant methylation and silencing of SHP-1 gene in chronic myelogenous leukemia cells
reciprocal regulation between miR (显示 MLXIP ELISA试剂盒)-148a/152 and DNMT1 in foam cells
MUC1 (显示 MUC1 ELISA试剂盒)-C is of functional importance to induction of DNMT1 and DNMT3b (显示 DNMT3B ELISA试剂盒) and, in turn, changes in DNA methylation (显示 HELLS ELISA试剂盒) patterns in cancer cells.
This study demonstrates novel regulatory circuits involving miR (显示 MLXIP ELISA试剂盒)-148a-3p/ERBB3 (显示 ERBB3 ELISA试剂盒)/AKT2 (显示 AKT2 ELISA试剂盒)/c-myc (显示 MYC ELISA试剂盒) and DNMT1 that controls bladder cancer progression, which may be useful in the development of more effective therapies against bladder cancer.
Dnmt1 was indispensable for oocyte cytoplasmic maturation, providing a novel role for Dnmt1 in the regulation of oocyte maturation.
Data show that the expression levels of the 5 epigenetic modifying genes Dnmt1, Dnmt3a (显示 DNMT3A ELISA试剂盒), Hdac1 (显示 HDAC1 ELISA试剂盒), Kdm3a (显示 KDM3A ELISA试剂盒) and Uhrf1 (显示 UHRF1 ELISA试剂盒) were higher in group pig in highland (TH) than in group Yorkshire in highland (YH).
DNMT1o is localized mainly in the nuclei of oocytes and early embryos, whereas DNMT1s is expressed in the ooplasm (显示 NLRP5 ELISA试剂盒) cortex of oocytes and cytoplasm of early embryos.
results indicate that loss of Dnmt1 in the maternal nucleus during SCNT significantly contributes to the unfaithful maintenance of methylation imprints in cloned embryos
Oocyte-specific Dnmt1 is cytoplasmic during early development.
Dnmt1 mRNA abundance plays an important role during protein regulation, Dnmt1 enzyme is mainly posttranscriptionally regulated.
DNMT1 silencing significantly decreased the methylation levels of miR (显示 MYLIP ELISA试剂盒)-29b promoter, up-regulated miR (显示 MYLIP ELISA试剂盒)-29b expression and inhibited bovine viral diarrhea virus replication.
Through down-regulating the expression of DNMT1, miR (显示 MYLIP ELISA试剂盒)-152 reduced Global DNA methylation (显示 HELLS ELISA试剂盒) and the activity of DNMT to reactivate the lactation signal transduction genes Akt (显示 AKT1 ELISA试剂盒) and Ppar gamma (显示 PPARG ELISA试剂盒).
More DNMT1 mRNA was detected in the transgenic somatic cell nuclear transfer (SCNT) group than the other three groups. Hsp 70.1 mRNA was detected in the in vitro fertilzation embryos. Mash2 (显示 ASCL2 ELISA试剂盒) mRNA was present at highest levels in transgenic SCNT embryos.
Our results indicate an essential role for Dnmt1 during bovine preimplantation development (显示 MTA2 ELISA试剂盒), and suggest proper transcriptional reprogramming of this gene family in SCNT embryos.
Dnmt1 is retained in the cytoplasm in metaphase II stage oocytes and zygotes, it enters the nuclei of 8-16 cell stage embryos
Abnormal gene expression of DNMT, INFT, and MHC1 was noted in the majority of cloned embryos, indicating inefficient nuclear reprogramming and retarded embryo development.
Results describe the alternative splicing and expression analysis of bovine DNA methyltransferase 1.
Report inhibition of DNA methyltransferase 1 expression in bovine fibroblast cells used for nuclear transfer.
MET1 is a thylakoid-associated TPR protein involved in photosystem II supercomplex formation and repair in Arabidopsis
Met1 gene expression throughout normal development, particularly in the flower
MET1 is a contributor to epigenetic diversity in Arabidopsis.
VIM (显示 VIM ELISA试剂盒) proteins regulate genome-wide epigenetic gene silencing through coordinated modulation of DNA methylation (显示 HELLS ELISA试剂盒) and histone modification status in collaboration with MET1
VIM (显示 VIM ELISA试剂盒) proteins function in transcriptional regulation via their roles in the MET1 DNA methylation (显示 HELLS ELISA试剂盒) pathway.
Genetic studies indicate that the Polycomb (显示 CBX2 ELISA试剂盒) Repressive Complex 2 (PRC2) but not the DNA METHYLTRANSFERASE1 (MET1) is involved in regulating imprinted expression in the embryo. [MET1]
MET1 restores body methylation, which is region-specific but random with respect to the affected CG sites, and is moderately although not decisively influenced by transcription.
There is a mechanistic link between two major epigenetic pathways involved in histone and DNA methylation (显示 HELLS ELISA试剂盒) in plants by physical interaction of MET1 with the FIS-PRC2 core component MEA.
Our results bear interesting similarities with cancer cells, which show global losses of DNA methylation (显示 HELLS ELISA试剂盒) but ectopic hypermethylation of genes previously marked by H3K27m3.
An intergenic nucleosome-free crossover hotspot 3a undergoes increased recombination activity in met1.
we extended this work by using a biotinylation tagging approach to characterize DNMT1 protein complexes in mouse erythroleukemic cells. We identified novel DNMT1 interactions with several hematopoietic transcription factors with essential roles in erythroid differentiation
The lack of Sirt7 (显示 SIRT7 ELISA试剂盒) is associated with reduced recruitment of DNMT1 and Sirt1 (显示 SIRT1 ELISA试剂盒) at rRNA genes leading to hyperacetylation of histones, reduced DNA methylation (显示 HELLS ELISA试剂盒), fragmentation of the nucleolar structure and loss of rDNA repeats leading to anincreased spontaneous immortalization of primary mouse embryonic fibroblasts.
The lethal Ogden syndrome-associated mutation of Naa10p disrupts its binding to the imprinting control region of H19 (显示 NCKAP1 ELISA试剂盒) and Dnmt1 recruitment.
The T1505 is crucial on the DNA methylation (显示 HELLS ELISA试剂盒) activity of DNMT1 through stabilizing its structure during ongoing round of DNA methylation (显示 HELLS ELISA试剂盒).
During neurogenesis, cortical neurons became protected from S-phase Chk1 (显示 CHEK1 ELISA试剂盒) pathway activation by the DNA methyltransferase Dnmt1, and underwent cell death after S-phase progression.
indispensable role of DNMT1-mediated epigenetic regulation in postnatal liver growth and regeneration
SETDB1 (显示 SETDB1 ELISA试剂盒) maintains silencing of intracisternal A particle, but in the absence of DNMT1, prolonged binding of NP95 (显示 UHRF1 ELISA试剂盒) to hemimethylated DNA transiently disrupts SETDB1 (显示 SETDB1 ELISA试剂盒)-dependent H3K9me3 deposition.
Arx and Dnmt1 that are sufficient for achieving targeted generation of beta cells from adult pancreatic alpha cells.
The results of this study showed that DNA Methyltransferase 1 is main role of Development of the Hippocampal Dentate Gyrus in mice.
DNA (cytosine-5-)-methyltransferase 1 has a role in the establishment and regulation of tissue-specific patterns of methylated cytosine residues. Aberrant methylation patterns are associated with certain human tumors and developmental abnormalities. Two transcript variants encoding different isoforms have been found for this gene.
DNA (cytosine-5)-methyltransferase 1
, CXXC-type zinc finger protein 9
, DNA MTase HsaI
, DNA methyltransferase HsaI
, DNA methyltransferase 1
, DNA (cytosine 5 ) methyltransferase 1
, DNA methyltransferase (cytosine 5 ) methyltransferase
, DNA methyltransferase b
, DNA MTase RnoIP
, DNA methyltransferase (cytosine-5) 1
, DNA methyltransferase I
, DNA MTase GgaI
, DNA MeTase
, DNA methyltransferase GgaI
, DNA MTase MmuI
, DNA methyltransferase MmuI