DNA (Cytosine-5)-Methyltransferase 1 (DNMT1) ELISA试剂盒

DNA (cytosine-5-)-methyltransferase 1 has a role in the establishment and regulation of tissue-specific patterns of methylated cytosine residues. 再加上,我们可以发DNA (Cytosine-5)-Methyltransferase 1 抗体 (475)DNA (Cytosine-5)-Methyltransferase 1 蛋白 (8)和数多这个蛋白质的别的产品。

list all ELISA KIts 基因 基因ID UniProt
DNMT1 1786 P26358
DNMT1 84350  
DNMT1 13433 P13864

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产品编号 适用 灵敏度 范围 图像 规格 供应商 交付 价格 详细
Pulldown of Dnmt1 using the Dnmt1-Trap:  Immunoprecipitations (IP) of Dnmt1 from a protein extract of HEK 293T cells. Size of DNMT1: 186 kDA. Primary antibody: anti-DNMT1 1:500. Secondary antibody: anti-rat 1:2000. Input (I), non-bound (FT) and bound (B) fractions were separated by SDS-PAGE followed by Coomassie staining and Western Blotting. Unlike conventional antibodies, the Dnmt1-Trap is free from heavy and/or light chain contaminants and therefore yields cleaner results. On cell lysate: HEK 293T and HeLa lysate (size DNMT1: 183 kDa). Dilution 1:500. Secondary antibody: anti-rat 647. Please note that the Dnmt1 antibody is not working with recombinant DNMT1. 250 μL Log in to see 23至28个工作日
¥2,623.26
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Pulldown of Dnmt1 using the Dnmt1-Trap:  Immunoprecipitations (IP) of Dnmt1 from a protein extract of HEK 293T cells. Size of DNMT1: 186 kDA. Primary antibody: anti-DNMT1 1:500. Secondary antibody: anti-rat 1:2000. Input (I), non-bound (FT) and bound (B) fractions were separated by SDS-PAGE followed by Coomassie staining and Western Blotting. Unlike conventional antibodies, the Dnmt1-Trap is free from heavy and/or light chain contaminants and therefore yields cleaner results. On cell lysate: HEK 293T and HeLa lysate (size DNMT1: 183 kDa). Dilution 1:500. Secondary antibody: anti-rat 647. Please note that the Dnmt1 antibody is not working with recombinant DNMT1. 20 Tests Log in to see 23至28个工作日
¥3,884.46
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0.054 ng/mL 0.156-10 ng/mL 96 Tests Log in to see 9至11个工作日
¥4,293.90
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小鼠 0.053 ng/mL 0.156-10 ng/mL 96 Tests Log in to see 9至11个工作日
¥4,410.90
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0.078 ng/mL 0.156-10 ng/mL   96 Tests Log in to see 24至29个工作日
¥6,140.16
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大鼠 0.059 ng/mL 0.15-10 ng/mL 96 Tests Log in to see 7至10个工作日
¥3,772.08
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Cow
  96 Tests Log in to see 9至12个工作日
¥3,655.55
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小鸡
  96 Tests Log in to see 9至12个工作日
¥3,946.88
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引用最多的DNA (Cytosine-5)-Methyltransferase 1 ELISA试剂盒

  1. ABIN1082202 : Qin, Leonhardt, Pichler: Regulation of DNA methyltransferase 1 by interactions and modifications. in Nucleus (Austin, Tex.) 2011 (PubMed)

适于 DNA (Cytosine-5)-Methyltransferase 1 相互作用对的更多 ELISA 试剂盒

Zebrafish DNA (Cytosine-5)-Methyltransferase 1 (DNMT1) interaction partners

  1. Dnmt1 stability requires UHRF1 (显示 UHRF1 ELISA试剂盒) phosphorylation and that crosstalk between the proteins is essential for the function of these two important epigenetic regulators during gastrulation

  2. Lsh (显示 HELLS ELISA试剂盒) Is Essential for Maintaining Global DNA Methylation (显示 HELLS ELISA试剂盒) Levels in Amphibia and Fish and Interacts Directly with Dnmt1.

  3. Dnmt1 is required for hematopoietic stem and progenitor cells maintenance via cebpa (显示 CEBPA ELISA试剂盒) regulation during definitive hematopoiesis in zebrafish

  4. These data provide the first evidence that Uhrf1 (显示 UHRF1 ELISA试剂盒) and Dnmt1 function is required for vertebrate lens development and maintenance.

  5. These results suggest that Dnmt1 activity helps direct histone methylation by Suv39h1 (显示 SUV39H1 ELISA试剂盒) and that, together, Dnmt1 and Suv39h1 (显示 SUV39H1 ELISA试剂盒) help guide the terminal differentiation of particular tissues.

  6. Data show that in dnmt1 homozygous mutants, reactivation of gfp expression occurs in a reproducible subset of cells, raising the possibility of different sensitivities or alternative silencing mechanisms in discrete cell populations.

  7. Thus, our data suggest that Dnmt1 is dispensable for pancreatic duct or endocrine cell formation, but not for acinar cell survival. In addition, Dnmt1 may influence the differentiation of pancreatic beta cell progenitors.

Human DNA (Cytosine-5)-Methyltransferase 1 (DNMT1) interaction partners

  1. the role of DNMT1 at sites of oxidative damage is to reduce transcription, potentially preventing transcription from interfering with the repair process.

  2. these results indicate that DNMT1 mediates aberrant methylation and silencing of SHP-1 gene in chronic myelogenous leukemia cells

  3. reciprocal regulation between miR (显示 MLXIP ELISA试剂盒)-148a/152 and DNMT1 in foam cells

  4. MUC1 (显示 MUC1 ELISA试剂盒)-C is of functional importance to induction of DNMT1 and DNMT3b (显示 DNMT3B ELISA试剂盒) and, in turn, changes in DNA methylation (显示 HELLS ELISA试剂盒) patterns in cancer cells.

  5. This study demonstrates novel regulatory circuits involving miR (显示 MLXIP ELISA试剂盒)-148a-3p/ERBB3 (显示 ERBB3 ELISA试剂盒)/AKT2 (显示 AKT2 ELISA试剂盒)/c-myc (显示 MYC ELISA试剂盒) and DNMT1 that controls bladder cancer progression, which may be useful in the development of more effective therapies against bladder cancer.

  6. a novel molecular mechanism by which MBD4 (显示 MBD4 ELISA试剂盒) inhibits GITR (显示 TNFRSF18 ELISA试剂盒) expression in a DNMT1-dependent manner

  7. a model in which the EZH2 (显示 EZH2 ELISA试剂盒)/HOXA11 (显示 HOXA11 ELISA试剂盒)-AS/LSD1 (显示 KDM1A ELISA试剂盒) complex and HOXA11 (显示 HOXA11 ELISA试剂盒)-AS/miR (显示 MLXIP ELISA试剂盒)-1297/EZH2 (显示 EZH2 ELISA试剂盒) cross-talk serve as critical effectors in gastric cancer tumorigenesis and progression.

  8. Studies indicate that DNA methylation (显示 HELLS ELISA试剂盒) is mediated by three DNA (Cytosine-5-)-Methyltransferase (DNMTs): DNMT1 is responsible for the maintenance of methylation patterns after DNA replication whereas DNMT3A (显示 DNMT3A ELISA试剂盒) and DNMT3B (显示 DNMT3B ELISA试剂盒) carry out de novo methylation, and DNMT inhibitors have showed promising results in clinical trials of prostate cancer.

  9. Our results suggest that epigenetic alteration of histone demethylation regulated by reduction of DNMT1 may control induction of EMT (显示 ITK ELISA试剂盒) and the CSC phenotype, which facilitates tumorigenesis in PCa (显示 FLVCR1 ELISA试剂盒) cells and has important therapeutic implications in targeting epigenetic regulation.

  10. results indicated that the age and total cholesterol concentrations were independent influential factors of ChREBP (显示 MLXIPL ELISA试剂盒) methylation and DNMT1 variants could probably influence LDL-C to further modify ChREBP (显示 MLXIPL ELISA试剂盒) DNA methylation (显示 HELLS ELISA试剂盒)

Pig (Porcine) DNA (Cytosine-5)-Methyltransferase 1 (DNMT1) interaction partners

  1. Dnmt1 was indispensable for oocyte cytoplasmic maturation, providing a novel role for Dnmt1 in the regulation of oocyte maturation.

  2. Data show that the expression levels of the 5 epigenetic modifying genes Dnmt1, Dnmt3a (显示 DNMT3A ELISA试剂盒), Hdac1 (显示 HDAC1 ELISA试剂盒), Kdm3a (显示 KDM3A ELISA试剂盒) and Uhrf1 (显示 UHRF1 ELISA试剂盒) were higher in group pig in highland (TH) than in group Yorkshire in highland (YH).

  3. DNMT1o is localized mainly in the nuclei of oocytes and early embryos, whereas DNMT1s is expressed in the ooplasm (显示 NLRP5 ELISA试剂盒) cortex of oocytes and cytoplasm of early embryos.

  4. results indicate that loss of Dnmt1 in the maternal nucleus during SCNT significantly contributes to the unfaithful maintenance of methylation imprints in cloned embryos

  5. Oocyte-specific Dnmt1 is cytoplasmic during early development.

  6. Dnmt1 mRNA abundance plays an important role during protein regulation, Dnmt1 enzyme is mainly posttranscriptionally regulated.

Cow (Bovine) DNA (Cytosine-5)-Methyltransferase 1 (DNMT1) interaction partners

  1. DNMT1 silencing significantly decreased the methylation levels of miR (显示 MYLIP ELISA试剂盒)-29b promoter, up-regulated miR (显示 MYLIP ELISA试剂盒)-29b expression and inhibited bovine viral diarrhea virus replication.

  2. Through down-regulating the expression of DNMT1, miR (显示 MYLIP ELISA试剂盒)-152 reduced Global DNA methylation (显示 HELLS ELISA试剂盒) and the activity of DNMT to reactivate the lactation signal transduction genes Akt (显示 AKT1 ELISA试剂盒) and Ppar gamma (显示 PPARG ELISA试剂盒).

  3. More DNMT1 mRNA was detected in the transgenic somatic cell nuclear transfer (SCNT) group than the other three groups. Hsp 70.1 mRNA was detected in the in vitro fertilzation embryos. Mash2 (显示 ASCL2 ELISA试剂盒) mRNA was present at highest levels in transgenic SCNT embryos.

  4. Our results indicate an essential role for Dnmt1 during bovine preimplantation development (显示 MTA2 ELISA试剂盒), and suggest proper transcriptional reprogramming of this gene family in SCNT embryos.

  5. Dnmt1 is retained in the cytoplasm in metaphase II stage oocytes and zygotes, it enters the nuclei of 8-16 cell stage embryos

  6. Abnormal gene expression of DNMT, INFT, and MHC1 was noted in the majority of cloned embryos, indicating inefficient nuclear reprogramming and retarded embryo development.

  7. Results describe the alternative splicing and expression analysis of bovine DNA methyltransferase 1.

  8. Report inhibition of DNA methyltransferase 1 expression in bovine fibroblast cells used for nuclear transfer.

Arabidopsis thaliana DNA (Cytosine-5)-Methyltransferase 1 (DNMT1) interaction partners

  1. MET1 is a thylakoid-associated TPR protein involved in photosystem II supercomplex formation and repair in Arabidopsis

  2. Met1 gene expression throughout normal development, particularly in the flower

  3. MET1 is a contributor to epigenetic diversity in Arabidopsis.

  4. VIM (显示 VIM ELISA试剂盒) proteins regulate genome-wide epigenetic gene silencing through coordinated modulation of DNA methylation (显示 HELLS ELISA试剂盒) and histone modification status in collaboration with MET1

  5. VIM (显示 VIM ELISA试剂盒) proteins function in transcriptional regulation via their roles in the MET1 DNA methylation (显示 HELLS ELISA试剂盒) pathway.

  6. Genetic studies indicate that the Polycomb (显示 CBX2 ELISA试剂盒) Repressive Complex 2 (PRC2) but not the DNA METHYLTRANSFERASE1 (MET1) is involved in regulating imprinted expression in the embryo. [MET1]

  7. MET1 restores body methylation, which is region-specific but random with respect to the affected CG sites, and is moderately although not decisively influenced by transcription.

  8. There is a mechanistic link between two major epigenetic pathways involved in histone and DNA methylation (显示 HELLS ELISA试剂盒) in plants by physical interaction of MET1 with the FIS-PRC2 core component MEA.

  9. Our results bear interesting similarities with cancer cells, which show global losses of DNA methylation (显示 HELLS ELISA试剂盒) but ectopic hypermethylation of genes previously marked by H3K27m3.

  10. An intergenic nucleosome-free crossover hotspot 3a undergoes increased recombination activity in met1.

Mouse (Murine) DNA (Cytosine-5)-Methyltransferase 1 (DNMT1) interaction partners

  1. reciprocal regulation between miR (显示 MLXIP ELISA试剂盒)-148a/152 and DNMT1 in foam cells

  2. indispensable role of DNMT1-mediated epigenetic regulation in postnatal liver growth and regeneration

  3. SETDB1 (显示 SETDB1 ELISA试剂盒) maintains silencing of intracisternal A particle, but in the absence of DNMT1, prolonged binding of NP95 (显示 UHRF1 ELISA试剂盒) to hemimethylated DNA transiently disrupts SETDB1 (显示 SETDB1 ELISA试剂盒)-dependent H3K9me3 deposition.

  4. Arx and Dnmt1 that are sufficient for achieving targeted generation of beta cells from adult pancreatic alpha cells.

  5. The results of this study showed that DNA Methyltransferase 1 is main role of Development of the Hippocampal Dentate Gyrus in mice.

  6. three DNA methyltransferases, Dnmt1, Dnmt3a (显示 DNMT3A ELISA试剂盒), and Dnmt3b (显示 DNMT3B ELISA试剂盒), have been identified. Dnmt3a (显示 DNMT3A ELISA试剂盒) and Dnmt3b (显示 DNMT3B ELISA试剂盒) are responsible for establishing DNA methylation (显示 HELLS ELISA试剂盒) patterns produced through their de novo-type DNA methylation (显示 HELLS ELISA试剂盒) activity in implantation stage embryos and during germ cell differentiation. Dnmt3-like (Dnmt3l (显示 TRDMT1 ELISA试剂盒)), which is a member of the Dnmt3 family but does not possess DNA methylation (显示 HELLS ELISA试剂盒)

  7. While lens epithelial cell survival requires DNMT1, morphologically normal lenses develop in the absence of both DNMT3A (显示 DNMT3A ELISA试剂盒) and DNMT3B (显示 DNMT3B ELISA试剂盒).

  8. Our results provide insights into the molecular basis of DNMT1 dysfunction in hereditary sensory and autonomic neuropathies with dementia and hearing loss patients and emphasize the importance of the TS domain in the regulation of DNA methylation (显示 HELLS ELISA试剂盒) in pluripotent and differentiating cells

  9. miR (显示 MLXIP ELISA试剂盒)-29a mimic transfection lowered collagen 1alpha1, DNMT1, DNMT3b (显示 DNMT3B ELISA试剂盒) and SET1A (显示 SETD1A ELISA试剂盒) expression in hepatic stellate cells.

  10. These results demonstrate that Dnmt1 and Dnmt3b (显示 DNMT3B ELISA试剂盒) cooperate to maintain DNA methylation (显示 HELLS ELISA试剂盒) and genomic integrity in the intestinal epithelium.

DNA (Cytosine-5)-Methyltransferase 1 (DNMT1) 抗原简介

Antigen Summary

DNA (cytosine-5-)-methyltransferase 1 has a role in the establishment and regulation of tissue-specific patterns of methylated cytosine residues. Aberrant methylation patterns are associated with certain human tumors and developmental abnormalities. Two transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with DNMT1

  • DNA (cytosine-5-)-methyltransferase 1 (DNMT1) 抗体
  • DNA (cytosine-5-)-methyltransferase 1 (dnmt1) 抗体
  • DNA (cytosine-5-)-methyltransferase 1 (Dnmt1) 抗体
  • DNA (cytosine-5)-methyltransferase 1 (MET1) 抗体
  • DNA methyltransferase (cytosine-5) 1 (Dnmt1) 抗体
  • ADCADN 抗体
  • AIM 抗体
  • cb983 抗体
  • cb1075 抗体
  • Cxxc9 抗体
  • DDM2 抗体
  • DECREASED DNA METHYLATION 2 抗体
  • dmnt1 抗体
  • DMT01 抗体
  • DMT1 抗体
  • DNA METHYLTRANSFERASE 抗体
  • DNA METHYLTRANSFERASE 01 抗体
  • DNA METHYLTRANSFERASE 1 抗体
  • Dnmt 抗体
  • Dnmt1o 抗体
  • fb05h01 抗体
  • HSN1E 抗体
  • m.MmuI 抗体
  • MCMT 抗体
  • Met-1 抗体
  • Met1 抗体
  • MET2 抗体
  • methyltransferase 1 抗体
  • METHYLTRANSFERASE 2 抗体
  • METHYLTRANSFERASE I 抗体
  • METI 抗体
  • MommeD2 抗体
  • mta 抗体
  • MTase 抗体
  • wu:fb05h01 抗体

Protein level used designations for DNMT1

DNA (cytosine-5)-methyltransferase 1 , ddn , CXXC-type zinc finger protein 9 , DNA MTase HsaI , DNA methyltransferase HsaI , m.HsaI , DNA methyltransferase 1 , DNA (cytosine 5 ) methyltransferase 1 , DNA methyltransferase (cytosine 5 ) methyltransferase , DNA methyltransferase b , DNA MTase RnoIP , DNA methyltransferase (cytosine-5) 1 , DNA methyltransferase I , MCMT , m.RnoIP , DNA MTase GgaI , DNA MeTase , DNA methyltransferase GgaI , m.GgaI , DNA MTase MmuI , DNA methyltransferase MmuI

GENE ID SPECIES
443549 Ovis aries
30430 Danio rerio
1786 Homo sapiens
476715 Canis lupus familiaris
606746 Sus scrofa
281119 Bos taurus
84350 Rattus norvegicus
396011 Gallus gallus
834975 Arabidopsis thaliana
13433 Mus musculus
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