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DCAF7 encodes a protein with multiple WD40 repeats which facilitate protein-protein interactions and thereby enable the assembly of multiprotein complexes. 再加上，我们可以发DCAF7 抗体 (55) 和 DCAF7 蛋白 (6)和数多这个蛋白质的别的产品。
these findings reveal an indirect role for Wdr68 in the BMP-Edn1-Jag1b signaling hierarchy and dorso-anterior expression of dlx1a/2a.
we show that while a GFP-Wdr68 fusion functionally substituted for craniofacial development in the zebrafish, that a Nuclear Export Signal (NES (显示 NES ELISA试剂盒)) fusion protein (GFPNESWdr68) failed to support craniofacial development
The initial characterization of wdr68 suggests an important role in craniofacial development for the highly conserved Wdr68-Dyrk1 (显示 DYRK1A ELISA试剂盒) protein complexes.
knockdown of DCAF7 reduced the degradation of DNA ligase I (显示 LIG1 ELISA试剂盒) in response to inhibition of proliferation and replacement of ubiquitylated lysine residues reduced the in vitro ubiquitylation of DNA ligase I (显示 LIG1 ELISA试剂盒) by Cul4-DDB1 and DCAF7. In contrast, a different E3 ubiquitin ligase regulates FEN-1 (显示 FEN1 ELISA试剂盒) turnover.
results demonstrate that the molecular chaperone (显示 HSP90AA1 ELISA试剂盒) TRiC/CCT (显示 TCP1 ELISA试剂盒) is essential for correct protein folding, DYRK1A (显示 DYRK1A ELISA试剂盒) binding, and nuclear accumulation of WDR68.
DYRK1A (显示 DYRK1A ELISA试剂盒) binds specifically to WDR68 in cells; the binding, but not the phosphorylation event, induces the nuclear translocation of WDR68.
Han11 was required to allow coupling of MEKK1 (显示 MAP3K1 ELISA试剂盒) to DYRK1 (显示 DYRK1A ELISA试剂盒) and HIPK2 (显示 HIPK2 ELISA试剂盒).
that AN11 may be a physiological regulator of GLI1 (显示 GLI1 ELISA试剂盒) transcriptional activity
This gene encodes a protein with multiple WD40 repeats which facilitate protein-protein interactions and thereby enable the assembly of multiprotein complexes. This protein has been shown to function as a scaffold protein for protein complexes involved in kinase signalling. This highly conserved gene is present in eukaryotic plants, fungi, and animals. The ortholog of this gene was first identified in plants as a key regulator of anthocyanin biosynthesis and flower pigmentation. Alternative splicing results in multiple transcript variants.
DDB1- and CUL4-associated factor 7
, dirty south
, AN11 homolog
, WD repeat domain 68
, DDB1 and CUL4 associated factor 7
, WD-repeat protein
, WD repeat-containing protein 68
, WD repeat-containing protein An11 homolog
, human anthocyanin
, seven-WD-repeat protein of the AN11 family-1