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The protein encoded by CBS acts as a homotetramer to catalyze the conversion of homocysteine to cystathionine, the first step in the transsulfuration pathway. 再加上，我们可以发Cystathionine-beta-Synthase 抗体 (123) 和 Cystathionine-beta-Synthase 蛋白 (15)和数多这个蛋白质的别的产品。
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Human CBS ELISA Kit for Sandwich ELISA - ABIN456995
Sun, Sun, Li, Pan, Xie, Wang, Zhang: Potential biomarkers predicting risk of pulmonary hypertension in congenital heart disease: the role of homocysteine and hydrogen sulfide. in Chinese medical journal 2014
Results indicate that activation of the cystathionine-beta-synthase (CBS) and its product hydrogen sulfide (CBS/H2S axis promotes colon carcinogenesis.
showed that N-homocysteinylation of collagen in Cbs(-/-) mice impairs its cross-linking
the findings of this study indicate that a deficiency in 3MST does not significantly affect endotoxemia, while a deficiency in CBS or CSE (显示 CTH ELISA试剂盒) slightly ameliorates the outcome of LPS (显示 TLR4 ELISA试剂盒)-induced endotoxemia in vivo.
These data confirm a key role for the H2S-generating enzymes Cbs and Cth (显示 CTH ELISA试剂盒) in pulmonary vascular development and homeostasis and in lung alveolarization.
genetic deficiency results in reduced Tet1 and Tet2 (显示 TET2 ELISA试剂盒) expression, which leads to hypermethylation of Foxp3 (显示 FOXP3 ELISA试剂盒), and impairment of Treg cell differentiation and immune homeostasis.
Elevated homocytsteine levels in the CBS-/+ mouse skeletal muscles caused diminished anti-oxidant capacity and contributed to enhanced total protein as well as PGC-1alpha (显示 PPARGC1A ELISA试剂盒) specific nitrotyrosylation after ischemia.
CBS disruption causes embryo retention and developmental delay in the mouse oviduct.
CBS is present in adrenocortical cells and accounts for H2S generation in adrenal glands. CBS is critical for maintenance of mitochondrial function and glucocorticoid production in adrenal cortex.
Elevating endogenous H2S via CBS over-expression in immortalized microglia not only reduced the expression of pro-inflammatory M1 genes, but also enhanced the anti-inflammatory M2 marker IL-10 (显示 IL10 ELISA试剂盒) production.
Cbs protein expression is upregulated in brain cortex following traumatic brain injury.
These findings may contribute to highlight that the MTHFR (显示 MTHFR ELISA试剂盒) and CBS polymorphisms involvement in sickle cell anemia (SCA)pathophysiology is likely to be far more complex than it was explored to date
Uterine artery hydrogen sulfide production is augmented with endothelium and smooth muscle CBS upregulation, contributing to uterine artery vasodilation in the estrogen-dominant physiological states in the proliferative phase of the menstrual cycle and pregnancy.
Common polymorphisms in MTHFR (显示 MTHFR ELISA试剂盒), methionine synthase (显示 MTR ELISA试剂盒) and cystathione beta lyase genes have no role in premature acute myocardial infarction in Pakistani population.
Inducible expression of CBS and CSE was found to be associated with a mineralizing phenotype in mesenchymal stem cells transitioning to mineralizing osteoblasts.
SNPs in CBS were not related to relevant changes in homocysteine levels in coronary artery disease patients or controls.
The CBS rs2124459 was associated with a reduced risk of cleft palate in both French and Belgian populations. These results highlight the prominent involvement of the vitamin B6-dependent transsulfuration pathway of homocysteine in orofacial cleft risk and the interest for evaluating vitamin B6 status in further population studies.
There is no ordinary conjunction between human CBS and severe sepsis/septic shock, but CBS genotypes are involved in disease susceptibility.
Oligomeric status of human cystathionine beta-synthase modulates AdoMet (显示 MAT1A ELISA试剂盒) binding.
Significant interactions were observed among the methylenetetrahydrofolate reductase (MTHFR (显示 MTHFR ELISA试剂盒); C677T; A1298C) and cystathionine-beta-synthase (CBS; T833C/844ins68, G919A) polymorphisms in the results for homocysteine (Hcy) levels, where heterozygous had higher values.
These findings indicate that greater synthesis of phosphatidylcholine (显示 SGMS1 ELISA试剂盒) and antioxidants contribute to the better performance and immuno-metabolic status in methionine-supplemented cows.
The protein encoded by this gene acts as a homotetramer to catalyze the conversion of homocysteine to cystathionine, the first step in the transsulfuration pathway. The encoded protein is allosterically activated by adenosyl-methionine and uses pyridoxal phosphate as a cofactor. Defects in this gene can cause cystathionine beta-synthase deficiency (CBSD), which can lead to homocystinuria. Multiple alternatively spliced transcript variants have been found for this gene.
, cystathionine beta-synthase
, cystathionine beta-synthase CBS
, hemoprotein H-450
, serine sulfhydrase
, methylcysteine synthase