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CDKN2A 抗体

(Cyclin-Dependent Kinase Inhibitor 2A (Melanoma, P16, Inhibits CDK4) (CDKN2A))
This gene generates several transcript variants which differ in their first exons. At least three alternatively spliced variants encoding distinct proteins have been reported, two of which encode structurally related isoforms known to function as inhibitors of CDK4 kinase. The remaining transcript includes an alternate first exon located 20 Kb upstream of the remainder of the gene\; this transcript contains an alternate open reading frame (ARF) that specifies a protein which is structurally unrelated to the products of the other variants. This ARF product functions as a stabilizer of the tumor suppressor protein p53 as it can interact with, and sequester, the E3 ubiquitin-protein ligase MDM2, a protein responsible for the degradation of p53. In spite of the structural and functional differences, the CDK inhibitor isoforms and the ARF product encoded by this gene, through the regulatory roles of CDK4 and p53 in cell cycle G1 progression, share a common functionality in cell cycle G1 control. This gene is frequently mutated or deleted in a wide variety of tumors, and is known to be an important tumor suppressor gene. [provided by RefSeq, Sep 2012].
CDKN2A 抗体  (AA 8-156) CDKN2A 抗体  (AA 8-156) CDKN2A 抗体 (AA 8-156) (ABIN7432619)

CDKN2A 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

CDKN2A 抗体  (C-Term) CDKN2A 抗体  (C-Term) CDKN2A 抗体 (C-Term) (ABIN1981278)

CDKN2A 适用: 人 WB, IF, FACS, IHC (p) 宿主: 兔 Polyclonal RB19093 unconjugated

Recombinant CDKN2A 抗体 Recombinant CDKN2A 抗体 Recombinant CDKN2A 抗体 (ABIN7504174)

CDKN2A 适用: 人 WB, IHC (f) 宿主: 兔 Monoclonal unconjugated Recombinant Antibody

CDKN2A 抗体 by 适用

Find CDKN2A 抗体 for a variety of species such as anti-Human CDKN2A, anti-Mouse CDKN2A, anti-Rat CDKN2A. The species listed below are among those available. Click on a link to go to the corresponding products.

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Find CDKN2A 抗体 validated for a specific application such as WB, IHC, ELISA, IF. Some of the available applications are listed below. Click on a link to go to the corresponding products.

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Find CDKN2A 抗体 with a specific epitope. The epitopes listed below are among those available. Click on a link to go to the corresponding products.

CDKN2A 抗体 by 克隆形成能力

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Find CDKN2A 抗体 with a specific conjugate such as Biotin, FITC, HRP. The conjugates listed below are among those available. Click on a link to go to the corresponding products.

Popular CDKN2A 抗体

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application WB, IHC, IP, ICC
Validations
  • (6)
Cat. No. ABIN7432619
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, IF, FACS, IHC (p)
Validations
  • (1)
  • (5)
Cat. No. ABIN1981278
Quantity 400 μL
Datasheet Datasheet
Reactivity Human
Application WB, IHC (f)
Validations
  • (4)
Cat. No. ABIN7504174
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application WB, IHC, IF
Validations
  • (4)
Cat. No. ABIN6139280
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, IHC (p)
Validations
  • (1)
  • (2)
Cat. No. ABIN6241061
Quantity 400 μL
Datasheet Datasheet
Reactivity Human
Application WB, IHC (f)
Validations
  • (3)
Cat. No. ABIN7504172
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application WB, IHC, ELISA
Validations
  • (2)
Cat. No. ABIN7329376
Quantity 50 μg
Datasheet Datasheet
Reactivity Human
Application IHC, ELISA
Validations
  • (2)
Cat. No. ABIN7365996
Quantity 50 μg
Datasheet Datasheet
Reactivity Human
Application WB
Validations
  • (2)
Cat. No. ABIN6243104
Quantity 400 μL
Datasheet Datasheet
Reactivity Human
Application IHC (f)
Validations
  • (2)
Cat. No. ABIN7504146
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application WB, IHC, IF, IC
Validations
  • (3)
Cat. No. ABIN7295238
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, ELISA
Validations
  • (1)
Cat. No. ABIN7323574
Quantity 50 μg
Datasheet Datasheet
Reactivity Human
Application WB, IHC, ELISA, IF
Validations
  • (1)
Cat. No. ABIN7323572
Quantity 50 μg
Datasheet Datasheet
Reactivity Mouse
Application WB, IHC, IP, ICC
Validations
  • (1)
Cat. No. ABIN7432622
Quantity 100 μL
Datasheet Datasheet
Reactivity Rat
Application WB, IHC, IP, ICC
Validations
  • (1)
Cat. No. ABIN7442825
Quantity 100 μL
Datasheet Datasheet

Latest Publications for our CDKN2A 抗体

Li, Zeng, Xing, Gullicksrud, Shan, Choi, Badovinac, Crotty, Peng, Xue: "Ezh2 programs TFH differentiation by integrating phosphorylation-dependent activation of Bcl6 and polycomb-dependent repression of p19Arf." in: Nature communications, Vol. 9, Issue 1, pp. 5452, (2019) (PubMed).

Michalak, Milevskiy, Joyce, Dekkers, Jamieson, Pal, Dawson, Hu, Orkin, Alexander, Lindeman, Smyth, Visvader: "Canonical PRC2 function is essential for mammary gland development and affects chromatin compaction in mammary organoids." in: PLoS biology, Vol. 16, Issue 8, pp. e2004986, (2019) (PubMed).

Novais, Diekman, Shapiro, Risbud: "p16Ink4a deletion in cells of the intervertebral disc affects their matrix homeostasis and senescence associated secretory phenotype without altering onset of senescence." in: Matrix biology : journal of the International Society for Matrix Biology, (2019) (PubMed).

Rui, Chen, Li, Xiao, Geng, Wang, Xu, Zhang, Dai: "CTGF Attenuates Tendon-Derived Stem/Progenitor Cell Aging." in: Stem cells international, Vol. 2019, pp. 6257537, (2019) (PubMed).

Ji, Zheng, Liu, Ren, Gao, Zhang, Li: "Resveratrol promotes oxidative stress to drive DLC1 mediated cellular senescence in cancer cells." in: Experimental cell research, Vol. 370, Issue 2, pp. 292-302, (2018) (PubMed).

Han, Li, Zhang, Qin, Yang, Wang, Yuan, Xia: "Brain lipid-binding protein promotes proliferation and modulates cell cycle in C6 rat glioma cells." in: International journal of oncology, Vol. 51, Issue 5, pp. 1439-1448, (2018) (PubMed).

Rosell��-Díez, Madisen, Bastide, Zeng, Joyner: "Cell-nonautonomous local and systemic responses to cell arrest enable long-bone catch-up growth in developing mice." in: PLoS biology, Vol. 16, Issue 6, pp. e2005086, (2018) (PubMed).

Xiong, Yang, Yang, Zhao, Tang, Ran: "Loss of the clock gene PER2 is associated with cancer development and altered expression of important tumor-related genes in oral cancer." in: International journal of oncology, Vol. 52, Issue 1, pp. 279-287, (2018) (PubMed).

Zhu, Xiao, Tang, Zou, Li, Zhang, Wang, Tang: "Spermidine prevents high glucose-induced senescence in HT-22 cells by upregulation of CB1 receptor." in: Clinical and experimental pharmacology & physiology, Vol. 45, Issue 8, pp. 832-840, (2018) (PubMed).

Crawford Parks, Marcellus, Langill, Ravel-Chapuis, Michaud, Cowan, Côté, Jasmin: "Novel Roles for Staufen1 in Embryonal and Alveolar Rhabdomyosarcoma via c-myc-dependent and -independent events." in: Scientific reports, Vol. 7, pp. 42342, (2017) (PubMed).

Aliases for CDKN2A 抗体

cyclin-dependent kinase inhibitor 2A (Cdkn2a) 抗体
cyclin-dependent kinase inhibitor 2A (LOC100731972) 抗体
cyclin-dependent kinase inhibitor 2A (LOC100340625) 抗体
cyclin dependent kinase inhibitor 2A (CDKN2A) 抗体
Arf 抗体
ARF 抗体
ARF-INK4a 抗体
CDK4I 抗体
CDKN2 抗体
CMM2 抗体
INK4 抗体
INK4A 抗体
INK4a-ARF 抗体
Ink4a/Arf 抗体
MLM 抗体
MTS-1 抗体
MTS1 抗体
P14 抗体
P14ARF 抗体
p16 抗体
P16 抗体
p16(INK4a) 抗体
P16-INK4A 抗体
p16Cdkn2a 抗体
P16INK4 抗体
P16INK4A 抗体
p16INK4a 抗体
P19 抗体
p19 抗体
p19ARF 抗体
P19ARF 抗体
Pctr1 抗体
TP16 抗体
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