Cullin 2 抗体
(Cullin 2 (CUL2))
Core component of multiple cullin-RING-based ECS (ElonginB/C-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of target proteins. May serve as a rigid scaffold in the complex and may contribute to catalysis through positioning of the substrate and the ubiquitin- conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1 (By similarity). The functional specificity of the ECS complex depends on the substrate recognition component. ECS(VHL) mediates the ubiquitination of hypoxia-inducible factor (HIF).
recommended
CUL2 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
recommended
recommended
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Datasheet
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Latest Publications for our Cullin 2 抗体
: "Twist1 Regulates Vimentin through Cul2 Circular RNA to Promote EMT in Hepatocellular Carcinoma." in: Cancer research, Vol. 78, Issue 15, pp. 4150-4162, (2018) (PubMed).: "KIF5B gene sequence variation and response of cardiac stroke volume to regular exercise." in: Physiological genomics, Vol. 36, Issue 2, pp. 79-88, (2009) (PubMed).
: "TBP-interacting protein 120B (TIP120B)/cullin-associated and neddylation-dissociated 2 (CAND2) inhibits SCF-dependent ubiquitination of myogenin and accelerates myogenic differentiation." in: The Journal of biological chemistry, Vol. 282, Issue 12, pp. 9017-28, (2007) (PubMed).
: "COMMD1 promotes the ubiquitination of NF-kappaB subunits through a cullin-containing ubiquitin ligase." in: The EMBO journal, Vol. 26, Issue 2, pp. 436-47, (2007) (PubMed).
: "Perturbation of SUMOlation enzyme Ubc9 by distinct domain within nucleoporin RanBP2/Nup358." in: The Journal of biological chemistry, Vol. 277, Issue 7, pp. 4755-63, (2002) (PubMed).
: "CUL-2 is required for the G1-to-S-phase transition and mitotic chromosome condensation in Caenorhabditis elegans." in: Nature cell biology, Vol. 1, Issue 8, pp. 486-92, (2000) (PubMed).
: "Genomic organization and chromosomal localization of the human CUL2 gene and the role of von Hippel-Lindau tumor suppressor-binding protein (CUL2 and VBP1) mutation and loss in renal-cell carcinoma ..." in: Genes, chromosomes & cancer, Vol. 26, Issue 1, pp. 20-8, (1999) (PubMed).
: "Human CUL-1, but not other cullin family members, selectively interacts with SKP1 to form a complex with SKP2 and cyclin A." in: Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research, Vol. 9, Issue 6, pp. 435-49, (1998) (PubMed).
: "The von Hippel-Lindau tumor-suppressor gene product forms a stable complex with human CUL-2, a member of the Cdc53 family of proteins." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 94, Issue 6, pp. 2156-61, (1997) (PubMed).
: "cul-1 is required for cell cycle exit in C. elegans and identifies a novel gene family." in: Cell, Vol. 85, Issue 6, pp. 829-39, (1996) (PubMed).
Aliases for Cullin 2 抗体
cullin 2 (cul2) 抗体cullin 2 (CUL2) 抗体
cullin-2 (PTRG_05231) 抗体
putative cullin-2 (cul-2) (Smp_079740) 抗体
cullin-2 (LOC100550749) 抗体
cullin 2 (Cul2) 抗体
cullin 2 L homeolog (cul2.L) 抗体
Cullin-2 (cul-2) 抗体
1300003D18Rik 抗体
4932411N15Rik 抗体
AI327301 抗体
ATCUL2 抗体
cul2 抗体
Cullin-2 抗体
cullin-2 抗体
cullin 2 抗体
F22D16.2 抗体
F22D16_2 抗体
fj48a06 抗体
LOC100221330 抗体
mKIAA4106 抗体
wu:fj48a06 抗体
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