Connector Enhancer of Kinase Suppressor of Ras 1 蛋白 (CNKSR1)

CNKSR1 is a necessary element in receptor tyrosine kinase pathways, possibly as a tyrosine phosphorylation target. 再加上,我们可以发Connector Enhancer of Kinase Suppressor of Ras 1 抗体 (38)和数多这个蛋白质的别的产品。

列出全部蛋白 基因 基因ID UniProt
CNKSR1 10256 Q969H4
小鼠 CNKSR1 CNKSR1 194231  
大鼠 CNKSR1 CNKSR1 298545  

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Insect Cells His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 88至92个工作日
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CNKSR1 蛋白 by Origin and Source

Origin 在表达 标记
Human ,
,

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Human Connector Enhancer of Kinase Suppressor of Ras 1 (CNKSR1) interaction partners

  1. The findings reveal SAM (显示 TTN 蛋白) domain-dependent oligomerization by AKT (显示 AKT1 蛋白) as a switch for CNK1 activation.

  2. tyrosine phosphorylation is an important mechanism to control the subcellular localization of CNK1 and its distinct biological functions.

  3. CNK1 mediates ephrinB1 (显示 EFNB1 蛋白) signaling that promotes cell migration through RhoA (显示 RHOA 蛋白) and JNK (显示 MAPK8 蛋白) activity.

  4. Studies indicate that CNK1-driven proliferation relies on Akt (显示 AKT1 蛋白)-dependent phosphorylation and inactivation of FoxO (显示 FOXO3 蛋白) proteins.

  5. These findings identify CNK1 as a new positive regulator of insulin (显示 INS 蛋白) signaling.

  6. Thus, CNK1 is an essential mediator of an oncogenic pathway involved in invasion of breast and cervical cancer cells and is therefore a putative target for cancer therapy.

  7. CNK1 promotes oncogenic signalling through Akt (显示 AKT1 蛋白) in breast cancer cell lines and tumours.

  8. hCNK1 associates with Rhophilin (显示 RHPN1 蛋白) and RalGDS (显示 RALGDS 蛋白), Rho and Ras effector molecules, respectively, suggesting that it acts as a scaffold protein (显示 HOMER1 蛋白) to mediate cross talk between the two pathways

  9. Data show that the connector enhancer of KSR 1 scaffold protein, through its binding of a RASSF1A/MST1 complex, participates in the proapoptotic signaling initiated by active Ras.

  10. CNK1 couples a subset of Rho exchange factors to activation of the JNK (显示 MAPK8 蛋白) MAP kinase (显示 MAPK1 蛋白) pathway and that signaling specificity is achieved through complexes containing both upstream activators and downstream targets of Rho.

蛋白简介Connector Enhancer of Kinase Suppressor of Ras 1 (CNKSR1)

蛋白简介

This gene is a necessary element in receptor tyrosine kinase pathways, possibly as a tyrosine phosphorylation target. It is involved in regulation of RAF in the MAPK pathway and may also play a role in a MAPK-independent pathway.

Gene names and symbols associated with CNKSR1

  • connector enhancer of kinase suppressor of Ras 1 (cnksr1)
  • connector enhancer of kinase suppressor of Ras 1 (CNKSR1)
  • connector enhancer of kinase suppressor of Ras 1 (Cnksr1)
  • connector enhancer of kinase suppressor of ras 1-like (LOC617552)
  • BC037758 蛋白
  • CNK 蛋白
  • CNK1 蛋白
  • CNKSR1 蛋白
  • KSR 蛋白
  • zgc:77200 蛋白

Protein level used designations for CNKSR1

connector enhancer of kinase suppressor of ras 1 , connector enhancer of kinase suppressor of Ras 1 , connector enhancer of kinase suppressor of ras 1-like , CNK homolog protein 1 , connector enhancer of KSR 1 , hCNK1

GENE ID SPECIES
402957 Danio rerio
469241 Pan troglodytes
100015613 Monodelphis domestica
100144653 Xenopus (Silurana) tropicalis
100158310 Xenopus laevis
100462050 Pongo abelii
100476443 Ailuropoda melanoleuca
10256 Homo sapiens
487359 Canis lupus familiaris
100624309 Sus scrofa
194231 Mus musculus
298545 Rattus norvegicus
617552 Bos taurus
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