Coiled-Coil Domain Containing 88C (CCDC88C) ELISA试剂盒

CCDC88C encodes a ubiquitously expressed coiled-coil domain-containing protein that interacts with the dishevelled protein and is a negative regulator of the Wnt signalling pathway. 再加上,我们可以发Coiled-Coil Domain Containing 88C 抗体 (3)和数多这个蛋白质的别的产品。

list all ELISA KIts 基因 基因ID UniProt
大鼠 CCDC88C CCDC88C 362770  
 CCDC88C CCDC88C 440193 Q9P219
小鼠 CCDC88C CCDC88C 68339 Q6VGS5
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适于 Coiled-Coil Domain Containing 88C 相互作用对的更多 ELISA 试剂盒

Human Coiled-Coil Domain Containing 88C (CCDC88C) interaction partners

  1. we demonstrated the relevance of Daple expression to gastric cancer progression.

  2. Thus, Daple activates Galphai proteins and enhances non-canonical Wnt signaling by Frizzled receptors, and its dysregulation can impact both tumor initiation and progression to metastasis.

  3. Spinocerebellar ataxia 40 (SCA40) displays typical cerebellar ataxia signs and pontocerebellar atrophy. Whole-exome sequencing led to the identification of a novel missense mutation in the gene CCDC88C in all SCA40-affected individuals. Cell-based assays showed that the SCA40 mutation causes an up-regulation of the JNK (显示 MAPK8 ELISA试剂盒) stress kinase signaling cascade that subsequently triggers programmed cell death.

  4. LDI-PCR revealed a fusion between CCDC88C exon 25 and PDGFRB (显示 PDGFRB ELISA试剂盒) exon 11.

  5. Our data validate CCDC88C as causing autosomal recessive, primary non-syndromic congenital hydrocephalus (显示 FOXC1 ELISA试剂盒), suggesting this gene may be an important cause of congenital hydrocephalus (显示 FOXC1 ELISA试剂盒).

Mouse (Murine) Coiled-Coil Domain Containing 88C (CCDC88C) interaction partners

  1. Findings indicate that Daple interacts with Dishevelled (显示 DVL2 ELISA试剂盒) to direct the Dishevelled (显示 DVL2 ELISA试剂盒)/protein kinase (显示 CDK7 ELISA试剂盒) lambda protein complex to activate Rac (显示 AKT1 ELISA试剂盒), which in turn mediates the non-canonical Wnt (显示 WNT2 ELISA试剂盒) signalling pathway required for cell migration.

  2. Identification of Daple, a Dvl-binding protein (显示 NKD1 ELISA试剂盒), that suppresses Wnt (显示 WNT2 ELISA试剂盒) signalling pathway.

Coiled-Coil Domain Containing 88C (CCDC88C) 抗原简介

Antigen Summary

This gene encodes a ubiquitously expressed coiled-coil domain-containing protein that interacts with the dishevelled protein and is a negative regulator of the Wnt signalling pathway. The protein encoded by this gene has a PDZ-domain binding motif in its C-terminus with which it interacts with the dishevelled protein. Dishevelled is a scaffold protein involved in the regulation of the Wnt signaling pathway. The Wnt signaling pathway plays an important role in embryonic development, tissue maintenance, and cancer progression. Mutations in this gene cause autosomal recessive, primary non-syndromic congenital hydrocephalus\; a condition characterized by excessive accumulation of cerebrospinal fluid in the ventricles of the brain.

Gene names and symbols associated with CCDC88C

  • coiled-coil domain containing 88C (Ccdc88c) 抗体
  • coiled-coil domain containing 88C (CCDC88C) 抗体
  • thyroid hormone receptor interactor 11 (TRIP11) 抗体
  • 0610010D24Rik 抗体
  • AV000935 抗体
  • AW324073 抗体
  • Daple 抗体
  • HKRP2 抗体
  • KIAA1509 抗体
  • MGC160122 抗体
  • mKIAA1509 抗体
  • RGD1307429 抗体

Protein level used designations for CCDC88C

coiled-coil domain containing 88C , DVL-binding protein DAPLE , Dvl-associating protein with a high frequency of leucine residues , hook-related protein 2 , protein Daple , coiled-coil domain-containing protein 88C , dvl-associating protein with a high frequency of leucine residues

GENE ID SPECIES
362770 Rattus norvegicus
423410 Gallus gallus
453108 Pan troglodytes
480418 Canis lupus familiaris
515039 Bos taurus
701155 Macaca mulatta
100014908 Monodelphis domestica
100083884 Ornithorhynchus anatinus
100152429 Sus scrofa
100230532 Taeniopygia guttata
100349859 Oryctolagus cuniculus
100540229 Meleagris gallopavo
440193 Homo sapiens
68339 Mus musculus
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