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CCDC88C encodes a ubiquitously expressed coiled-coil domain-containing protein that interacts with the dishevelled protein and is a negative regulator of the Wnt signalling pathway. 再加上，我们可以发Coiled-Coil Domain Containing 88C 抗体 (3)和数多这个蛋白质的别的产品。
we demonstrated the relevance of Daple expression to gastric cancer progression.
Thus, Daple activates Galphai proteins and enhances non-canonical Wnt signaling by Frizzled receptors, and its dysregulation can impact both tumor initiation and progression to metastasis.
Spinocerebellar ataxia 40 (SCA40) displays typical cerebellar ataxia signs and pontocerebellar atrophy. Whole-exome sequencing led to the identification of a novel missense mutation in the gene CCDC88C in all SCA40-affected individuals. Cell-based assays showed that the SCA40 mutation causes an up-regulation of the JNK (显示 MAPK8 ELISA试剂盒) stress kinase signaling cascade that subsequently triggers programmed cell death.
LDI-PCR revealed a fusion between CCDC88C exon 25 and PDGFRB (显示 PDGFRB ELISA试剂盒) exon 11.
Our data validate CCDC88C as causing autosomal recessive, primary non-syndromic congenital hydrocephalus (显示 FOXC1 ELISA试剂盒), suggesting this gene may be an important cause of congenital hydrocephalus (显示 FOXC1 ELISA试剂盒).
Findings indicate that Daple interacts with Dishevelled (显示 DVL2 ELISA试剂盒) to direct the Dishevelled (显示 DVL2 ELISA试剂盒)/protein kinase (显示 CDK7 ELISA试剂盒) lambda protein complex to activate Rac (显示 AKT1 ELISA试剂盒), which in turn mediates the non-canonical Wnt (显示 WNT2 ELISA试剂盒) signalling pathway required for cell migration.
Identification of Daple, a Dvl-binding protein (显示 NKD1 ELISA试剂盒), that suppresses Wnt (显示 WNT2 ELISA试剂盒) signalling pathway.
This gene encodes a ubiquitously expressed coiled-coil domain-containing protein that interacts with the dishevelled protein and is a negative regulator of the Wnt signalling pathway. The protein encoded by this gene has a PDZ-domain binding motif in its C-terminus with which it interacts with the dishevelled protein. Dishevelled is a scaffold protein involved in the regulation of the Wnt signaling pathway. The Wnt signaling pathway plays an important role in embryonic development, tissue maintenance, and cancer progression. Mutations in this gene cause autosomal recessive, primary non-syndromic congenital hydrocephalus\; a condition characterized by excessive accumulation of cerebrospinal fluid in the ventricles of the brain.
coiled-coil domain containing 88C
, DVL-binding protein DAPLE
, Dvl-associating protein with a high frequency of leucine residues
, hook-related protein 2
, protein Daple
, coiled-coil domain-containing protein 88C
, dvl-associating protein with a high frequency of leucine residues