Cell Division Cycle Associated 7-Like 蛋白 (CDCA7L)

Plays a role in transcriptional regulation as a repressor that inhibits monoamine oxidase A (MAOA) activity and gene expression by binding to the promoter. 再加上,我们可以发Cell Division Cycle Associated 7-Like 抗体 (45)Cell Division Cycle Associated 7-Like 试剂盒 (3)和数多这个蛋白质的别的产品。

列出全部蛋白 基因 基因ID UniProt
CDCA7L 217946 Q922M5
CDCA7L 619566 Q4G059
CDCA7L 55536 Q96GN5

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Insect Cells His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 78至82个工作日
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Insect Cells 小鼠 His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 78至82个工作日
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小麦胚 GST tag 10 μg Log in to see 29至34个工作日
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酵母菌 大鼠 His tag   1 mg Log in to see 24至35个工作日
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CDCA7L 蛋白 by Origin and Source

Origin 在表达 标记
Mouse (Murine)

Rat (Rattus)

Human ,
,

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Mouse (Murine) Cell Division Cycle Associated 7-Like (CDCA7L) interaction partners

  1. Mouse JPO2/RAM2 (Cdca7l) interacts with cMyc (显示 MYC 蛋白).

Human Cell Division Cycle Associated 7-Like (CDCA7L) interaction partners

  1. We identify the Myc (显示 MYC 蛋白)-interacting protein JPO2 and its partner binding protein LEDGF/p75 (显示 PSIP1 蛋白) as critical modulators of PI3K (显示 PIK3CA 蛋白)/AKT (显示 AKT1 蛋白) signaling and metastasis in medulloblastoma

  2. common LEDGF/p75 (显示 PSIP1 蛋白) interaction interface shared by JPO2, PogZ (显示 POGZ 蛋白), MLL1, IWS1 and HIV IN

  3. The data are consistent with the rs4487645-CDCA7L loci being responsible for the chromosome 7p11.2 association with multiple myeloma risk, probably exerting its effects through an extended pathway involving IRF4 (显示 IRF4 蛋白) and MYC (显示 MYC 蛋白).

  4. Data indicate that JPO2 and LEDGF/p75 (显示 PSIP1 蛋白) interact directly and specifically in vivo through the specific interaction domain of JPO2 and the C-terminal domain of LEDGF/p75 (显示 PSIP1 蛋白).

  5. CDCA7L was able to activate the extracellular signal-regulated kinase 1/2 (显示 MAPK3 蛋白) (ERK1/2) signaling pathway and regulate the cell cycle, thus promoting HCC (显示 FAM126A 蛋白) progression.

  6. Reduction in R1 repressor protein correlates significantly with an increase (approximately 40%) in monoamine oxidase A (显示 MAOA 蛋白) protein levels within the major depressive disorder groups compared with controls.

  7. monoamine oxidase A (显示 MAOA 蛋白) activation of glucocorticoids and androgens is regulated differently by R1 and Sp1 (显示 PSG1 蛋白)

  8. demonstrates the functions of MAO A (显示 MAOA 蛋白) and its repressor R1(RAM2/CDCA7L/JPO2) in apoptotic signaling pathways

  9. Over-expression of JPO2 resulted in a modest but reproducible inhibition of HIV-1 replication, consistent with competition between integrase and JPO2 for binding to LEDGF/p75 (显示 PSIP1 蛋白)

蛋白简介Cell Division Cycle Associated 7-Like (CDCA7L)

蛋白简介

Plays a role in transcriptional regulation as a repressor that inhibits monoamine oxidase A (MAOA) activity and gene expression by binding to the promoter. Play an important oncogenic role in mediating the full transforming effect of MYC in medulloblastoma cells. Involved in apoptotic signaling pathways\; May act downstream of P38-kinase and BCL-2, but upstream of CASP3/caspase-3 as well as CCND1/cyclin D1 and E2F1 (By similarity).

Gene names and symbols associated with CDCA7L

  • cell division cycle associated 7-like (CDCA7L)
  • cell division cycle associated 7-like (cdca7l)
  • cell division cycle associated 7-like (LOC100348574)
  • cell division cycle associated 7 like (Cdca7l)
  • BC006933 蛋白
  • JPO2 蛋白
  • MGC154777 蛋白
  • R1 蛋白
  • RAM2 蛋白
  • RAPGEF5 蛋白

Protein level used designations for CDCA7L

cell division cycle associated 7-like , transcription factor RAM2 , cell division cycle-associated 7-like protein-like , cell division cycle-associated 7-like protein , Rap guanine nucleotide exchange factor (GEF) 5

GENE ID SPECIES
100067524 Equus caballus
472306 Pan troglodytes
711948 Macaca mulatta
779344 Xenopus laevis
100348574 Oryctolagus cuniculus
100394869 Callithrix jacchus
100454683 Pongo abelii
100472794 Ailuropoda melanoleuca
100585065 Nomascus leucogenys
217946 Mus musculus
619566 Rattus norvegicus
55536 Homo sapiens
420608 Gallus gallus
482347 Canis lupus familiaris
100518624 Sus scrofa
514631 Bos taurus
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