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Plays a role in transcriptional regulation as a repressor that inhibits monoamine oxidase A (MAOA) activity and gene expression by binding to the promoter. 再加上，我们可以发Cell Division Cycle Associated 7-Like 抗体 (45) 和 Cell Division Cycle Associated 7-Like 试剂盒 (3)和数多这个蛋白质的别的产品。
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Mouse JPO2/RAM2 (Cdca7l) interacts with cMyc (显示 MYC 蛋白).
We identify the Myc (显示 MYC 蛋白)-interacting protein JPO2 and its partner binding protein LEDGF/p75 (显示 PSIP1 蛋白) as critical modulators of PI3K (显示 PIK3CA 蛋白)/AKT (显示 AKT1 蛋白) signaling and metastasis in medulloblastoma
common LEDGF/p75 (显示 PSIP1 蛋白) interaction interface shared by JPO2, PogZ (显示 POGZ 蛋白), MLL1, IWS1 and HIV IN
The data are consistent with the rs4487645-CDCA7L loci being responsible for the chromosome 7p11.2 association with multiple myeloma risk, probably exerting its effects through an extended pathway involving IRF4 (显示 IRF4 蛋白) and MYC (显示 MYC 蛋白).
Data indicate that JPO2 and LEDGF/p75 (显示 PSIP1 蛋白) interact directly and specifically in vivo through the specific interaction domain of JPO2 and the C-terminal domain of LEDGF/p75 (显示 PSIP1 蛋白).
CDCA7L was able to activate the extracellular signal-regulated kinase 1/2 (显示 MAPK3 蛋白) (ERK1/2) signaling pathway and regulate the cell cycle, thus promoting HCC (显示 FAM126A 蛋白) progression.
Reduction in R1 repressor protein correlates significantly with an increase (approximately 40%) in monoamine oxidase A (显示 MAOA 蛋白) protein levels within the major depressive disorder groups compared with controls.
monoamine oxidase A (显示 MAOA 蛋白) activation of glucocorticoids and androgens is regulated differently by R1 and Sp1 (显示 PSG1 蛋白)
demonstrates the functions of MAO A (显示 MAOA 蛋白) and its repressor R1(RAM2/CDCA7L/JPO2) in apoptotic signaling pathways
Over-expression of JPO2 resulted in a modest but reproducible inhibition of HIV-1 replication, consistent with competition between integrase and JPO2 for binding to LEDGF/p75 (显示 PSIP1 蛋白)
Plays a role in transcriptional regulation as a repressor that inhibits monoamine oxidase A (MAOA) activity and gene expression by binding to the promoter. Play an important oncogenic role in mediating the full transforming effect of MYC in medulloblastoma cells. Involved in apoptotic signaling pathways\; May act downstream of P38-kinase and BCL-2, but upstream of CASP3/caspase-3 as well as CCND1/cyclin D1 and E2F1 (By similarity).
cell division cycle associated 7-like
, transcription factor RAM2
, cell division cycle-associated 7-like protein-like
, cell division cycle-associated 7-like protein
, Rap guanine nucleotide exchange factor (GEF) 5