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The protein encoded by CDC27 shares strong similarity with Saccharomyces cerevisiae protein Cdc27, and the gene product of Schizosaccharomyces pombe nuc 2.
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Cdc27 directs cyclin D1 (显示 CCND1 抗体) to alternative degradation by anaphase promoting complex/cyclosome.
Data indicate that UBE2S and APC3 co-regulate the expression level of P21 at G2/M check point via the ubiquitin-proteasome system.
Cdc27 is a novel binding partner of Elmo1 (显示 ELMO1 抗体).Cdc27-Elmo1 (显示 ELMO1 抗体) has a cellular role independent from the Elmo-Dock1 (显示 DOCK1 抗体)-Rac (显示 AKT1 抗体) signal module.
miR (显示 MLXIP 抗体)-27a could modulate proliferation and radiosensitivity of TNBC cells. CDC-27 is a direct target of miR (显示 MLXIP 抗体)-27a and its downregulation conferred increased radioresistance of the cells.
These findings suggested that polymorphisms in cdc27 may contribute to the susceptibility of BC though functional studies are needed to further elucidate the underling mechanisms of the associations
The structures show how one APC16 (显示 ANAPC16 抗体) binds asymmetrically to the symmetric APC3 dimer and, together with biochemistry and prior data, explain how APC16 (显示 ANAPC16 抗体) recruits APC7 (显示 ANAPC7 抗体) to APC3.
Low cdc27 and high securin (显示 PTTG1 抗体) expression predict short survival for breast cancer patients.
Down-regulation of CDC27 protein is associated with radiation resistance.
Data indicate that additional density present in the anaphase-promoting complex (APC (显示 APC 抗体)/C) structure, proximal to Apc3/Cdc27 of the (tetratricopeptide repeat) lobe, is assigned to the TPR subunit Apc7 (显示 ANAPC7 抗体), a subunit specific to vertebrate APC (显示 APC 抗体)/C.
the biochemical, structural, and cellular determinants of the novel interaction between MCPH1 (显示 MCPH1 抗体) and Cdc27 and suggest that this interaction may occur within the larger context of MCPH1 (显示 MCPH1 抗体)-APC (显示 APC 抗体)/C.
phosphorylation of Cdc27 by CKII (显示 CSNK2A1 抗体) is involved in TGF-beta (显示 TGFB1 抗体)-induced activation of APC (显示 APC 抗体).
The protein encoded by this gene shares strong similarity with Saccharomyces cerevisiae protein Cdc27, and the gene product of Schizosaccharomyces pombe nuc 2. This protein is a component of anaphase-promoting complex (APC), which is composed of eight protein subunits and highly conserved in eucaryotic cells. APC catalyzes the formation of cyclin B-ubiquitin conjugate that is responsible for the ubiquitin-mediated proteolysis of B-type cyclins. This protein and 3 other members of the APC complex contain the TPR (tetratricopeptide repeat), a protein domain important for protein-protein interaction. This protein was shown to interact with mitotic checkpoint proteins including Mad2, p55CDC and BUBR1, and thus may be involved in controlling the timing of mitosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
cell division cycle 27 homolog
, cell division cycle protein 27 homolog
, cell division cycle protein 27
, CDC27 homolog
, anaphase promoting complex subunit 3
, anaphase-promoting complex subunit 3
, anaphase-promoting complex, protein 3
, nuc2 homolog