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CDC20 appears to act as a regulatory protein interacting with several other proteins at multiple points in the cell cycle. 再加上，我们可以发CDC20 抗体 (218) 和 CDC20 蛋白 (7)和数多这个蛋白质的别的产品。
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The ABBA-KEN (显示 PCNT ELISA试剂盒)-ABBA amino acid motif cassette holds the Mitotic Checkpoint (显示 BUB3 ELISA试剂盒) Complex (MCC) onto the Anaphase-Promoting Complex-Cyclosome (APC (显示 APC ELISA试剂盒)/C) by binding the two Cdc20 molecules in the MCC-APC (显示 APC ELISA试剂盒)/C complex.
It discuses the roles of Cdc20 in SAC (显示 ADCY10 ELISA试剂盒) signalling and mitotic exit, describe how the integration of traditional approaches with emerging technologies has revealed new details of Cdc20 functions, comment about the potential of Cdc20 as a therapeutic target for the treatment of human malignancies.
Prostate cancer-derived SPOP (显示 SPOP ELISA试剂盒) mutants failed to interact with Cdc20 to promote its degradation. As a result, SPOP (显示 SPOP ELISA试剂盒)-deficient prostate cancer cells with elevated Cdc20 expression became resistant to a pharmacological Cdc20 inhibitor.
High CDC20 expression is associated with metastatic castration-resistant prostate cancer growth and reduces chemosensitivity .
These results provide novel insight into the mechanisms underlying the aberrant capability of NUP98 (显示 NUP98 ELISA试剂盒) oncoproteins to interact with APC (显示 APC ELISA试剂盒)/C(Cdc20) and to interfere with its function.
In lung adenocarcinoma patients, overexpression of cell division cycle 20 was significantly associated with bigger primary tumor size, higher MKI67 (显示 MKI67 ELISA试剂盒) level, higher DNA ploidy level, and poor prognosis.
CDC20 may have a role in carcinoma of the breast, colon, endometrium, and prostate
Overexpression of Cdc20 may serve as an independent predictor for biochemical recurrence in patients of clinically localized prostate cancer undergoing laparoscopic radical prostatectomy without neoadjuvant therapy.
Results show that CYP1B1 (显示 CYP1B1 ELISA试剂盒) may promote renal cell carcinoma development by inducing CDC20 expression and inhibiting apoptosis through the down-regulation of DAPK1 (显示 DAPK1 ELISA试剂盒).
Study describes a positive feedback loop centred on cyclin A2 (显示 CCNA2 ELISA试剂盒)-Cdk2 (显示 CDK2 ELISA试剂盒) inhibition of interphase APC (显示 APC ELISA试剂盒)/C-Cdc20 to allow further cyclin A2 (显示 CCNA2 ELISA试剂盒) accumulation and mitotic entry.
Cdc20 auto-ubiquitylation does not play a major role in terminating Cdc20 activation.
Dephosphorylation of Cdc20 is required for its loading and activation of the APC/C ubiquitin ligase.
A role for the fizzy/cdc20 family of proteins in activation of the APC (显示 APC ELISA试剂盒)/C distinct from substrate recruitment is reported.
Cdc20 hypomorphism causes chromatin bridging and chromosome misalignment, revealing a requirement for Cdc20 in efficient sister chromosome separation and chromosome-microtubule attachment.
The physiologically effective threshold level of Cdc20 is high for female meiosis I.
Results indicate that Cdc20 also contributes to post-anaphase activation of the APC (显示 APC ELISA试剂盒)/C.
The seven tandem WD motifs of Cdc20 they are required for speriolin binding and for localization of Cdc20 to the centrosomes and nucleus, suggesting that speriolin might regulate or stabilize the folding of Cdc20 during meiosis in spermatogenic cells
Data suggest that Mad2 (显示 MXI1 ELISA试剂盒) and BubR1 (显示 BUB1B ELISA试剂盒) must cooperate to inhibit Cdc20 activity.
Cdc20 is degraded through two independent degradation signals (degrons), the KEN (显示 PCNT ELISA试剂盒) box and a newly described CRY (显示 CRY2 ELISA试剂盒) box.
Cdc20 and securin (显示 PTTG1 ELISA试剂盒) double mutant embryos could not maintain the metaphase arrest, suggesting a role of securin (显示 PTTG1 ELISA试剂盒) in preventing mitotic exit
Expression of the cdc20 gene is down-regulated by zif268 (显示 EGR1 ELISA试剂盒) in neuronal cells; altered expression of proteasome-regulatory genes following zif268 (显示 EGR1 ELISA试剂盒) induction may be a key component of long-lasting CNS plasticity.
Cdc20 is required for the anaphase onset of the first meiosis but not the second meiosis in mouse oocytes
findings suggest a novel function of HSF1 (显示 HSF1 ELISA试剂盒) frequently overexpressed in cancer cells, to inhibit APC (显示 APC ELISA试剂盒)/C activity by interacting with Cdc20, and to result in aneuploidy development and genomic instability
porcine FZR1 and CDC20 work on the maintenance of meiotic arrest at the first meiotic prophase and on the exit from M1
CDC20 appears to act as a regulatory protein interacting with several other proteins at multiple points in the cell cycle. It is required for two microtubule-dependent processes, nuclear movement prior to anaphase and chromosome separation.
cell division cycle 20 homolog
, CDC20 cell division cycle 20 homolog
, cell division cycle protein 20 homolog
, cell cycle protein p55CDC