Cell Adhesion Molecule with Homology To L1CAM (Close Homolog of L1) 蛋白 (CHL1)

The protein encoded by CHL1 is a member of the L1 gene family of neural cell adhesion molecules. 再加上,我们可以发CHL1 抗体 (17)CHL1 试剂盒 (10)和数多这个蛋白质的别的产品。

列出全部蛋白 基因 基因ID UniProt
CHL1 10752 O00533
CHL1 12661 P70232

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人细胞 小鼠 His tag 50 μg Log in to see 14至15个工作日
¥3,859.25
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大肠杆菌(E. Coli) His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 48至57个工作日
¥108,861.33
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大肠杆菌(E. Coli) 小鼠 His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 48至57个工作日
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Insect Cells 小鼠 rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 88至97个工作日
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Insect Cells His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 88至92个工作日
¥278,287.59
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人细胞 His tag 50 μg Log in to see 14至15个工作日
¥3,859.25
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小麦胚 GST tag 10 μg Log in to see 29至34个工作日
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CHL1 蛋白 by Origin and Source

Origin 在表达 标记
Human , , ,
, ,
Mouse (Murine) , ,
, ,

引用最多的CHL1 蛋白

  1. Mouse (Murine) CHL1 Protein expressed in Human Cells - ABIN2008733 : Muzny, Scherer, Kaul, Wang, Yu, Sudbrak, Buhay, Chen, Cree, Ding, Dugan-Rocha, Gill, Gunaratne, Harris, Hawes, Hernandez, Hodgson, Hume, Jackson, Khan, Kovar-Smith, Lewis, Lozado, Metzker et al.: The DNA sequence, annotation and analysis of human chromosome 3. ... in Nature 2006 (PubMed)
    Show all 4 references for 2008733

更多Cell Adhesion Molecule with Homology To L1CAM (Close Homolog of L1) (CHL1)互动伙伴

Human Cell Adhesion Molecule with Homology To L1CAM (Close Homolog of L1) (CHL1) interaction partners

  1. Results indicate that close homolog of L1 protein (CHL1) is downregulated by hypermethylation and that this epigenetic alteration is an independent prognostic factor in breast cancer (BC).

  2. CHL1 expression patient-derived lymphoblasts correlated with clinical outcome in depressive disorder patients.

  3. our findings suggest that miR-590-5p acts as an oncogene by targeting the CHL1 gene and promotes cervical cancer proliferation

  4. There was no statistical association between polymorphisms of the CHL1 gene and idiopathic scoliosis in a Chinese population.

  5. Our data collectively indicate that miR (显示 MLXIP 蛋白)-182 in PTC (显示 F9 蛋白) promotes cell proliferation and invasion through direct suppression of CHL1 (显示 DDX11 蛋白), supporting the potential utility of miR (显示 MLXIP 蛋白)-182 inhibition as a novel therapeutic strategy against PTC (显示 F9 蛋白).

  6. The rs2272522 polymorphism (in the CHL1 gene) was found to exhibit a highly significant association with schizophrenia in the Qatari population.

  7. In 1 of 113 Colombian children with refractory epilepsy, MLPA showed a subtelomeric duplication of exon 3 of CHL1, also present in 2 relatives.

  8. CHL1 has a role in human breast tumorigenesis and progression

  9. The miRNA miR (显示 MLXIP 蛋白)-151-3p had 6.7-fold higher basal expression in paroxetine-sensitive LCLs. This corresponds with lower expression of CHL1 (显示 DDX11 蛋白), a target of miR (显示 MLXIP 蛋白)-151-3p

  10. BACE1(-/-) axon guidance defects are likely the result of abrogated BACE1 processing of CHL1 and BACE1 deficiency produces a CHL1 loss-of-function phenotype

Mouse (Murine) Cell Adhesion Molecule with Homology To L1CAM (Close Homolog of L1) (CHL1) interaction partners

  1. Findings indicate that disrupted-in-schizophrenia 1 (DISC1 (显示 DISC1 蛋白)) and close homolog of L1 may engage in physical and functional interaction in neural development, supporting the notion that DISC1 (显示 DISC1 蛋白) regulates neurite outgrowth with a receptor belonging to the neural cell adhesion molecules.

  2. results demonstrate that CHL1 regulates signal transduction pathways through constitutively active 5-HT2c receptor isoforms, thereby altering 5-HT2c receptor functions and implicating CHL1 as a new modulator of the serotonergic system.

  3. This study provided novel evidence for the functional importance of CHL1 in the post-natal maturation and maintenance of inhibitory circuits and synaptic plasticity in the mouse hippocampus.

  4. homophilic CHL1 transinteractions regulate early differentiation of NSCs. heterophilic transinteractions of CHL1 with vitronectin (显示 VTN 蛋白), integrins, and plasminogen (显示 PLG 蛋白) activators regulate neuritogenesis and neural cell migration later in cerebellar morphogenesis.

  5. CHL1 is a novel intrinsic factor (显示 GIF 蛋白) that is involved in carotid body function and in the ventilatory response to acute hypoxia.

  6. CHL1 endocytosis are required for CHL1-dependent neurite outgrowth.

  7. CHL1 might play an important role in hypoxia damage regulation.

  8. BACE1(-/-) axon guidance defects are likely the result of abrogated BACE1 processing of CHL1 and BACE1 deficiency produces a CHL1 loss-of-function phenotype

  9. L1 and CHL1 are cleaved by BACE1 (显示 BACE 蛋白) under physiological conditions

  10. This study provided evidence that the CHL1 affect the repair of the blood-spinal cord barrier repair in soinal cord injury.

蛋白简介CHL1

蛋白简介

The protein encoded by this gene is a member of the L1 gene family of neural cell adhesion molecules. It is a neural recognition molecule that may be involved in signal transduction pathways. The deletion of one copy of this gene may be responsible for mental defects in patients with 3p- syndrome. This protein may also play a role in the growth of certain cancers. Alternate splicing results in both coding and non-coding variants.

Gene names and symbols associated with CHL1

  • cell adhesion molecule L1-like (CHL1)
  • cell adhesion molecule with homology to L1CAM (Chl1)
  • A530023M13Rik 蛋白
  • AI465420 蛋白
  • CALL 蛋白
  • L1CAM2 蛋白
  • LICAM2 蛋白

Protein level used designations for CHL1

L1 cell adhesion molecule 2 , cell adhesion molecule with homology to L1CAM (close homolog of L1) , cell adhesion molecule with homology to L1CAM (close homologue of L1) , close homolog of L1 , neural cell adhesion molecule L1-like protein , chl1-like protein

GENE ID SPECIES
10752 Homo sapiens
12661 Mus musculus
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