Cdk5 and Abl Enzyme Substrate 1 (CABLES1) ELISA试剂盒

CABLES1 encodes a protein involved in regulation of the cell cycle through interactions with several cyclin-dependent kinases. 再加上,我们可以发Cdk5 and Abl Enzyme Substrate 1 抗体 (26)Cdk5 and Abl Enzyme Substrate 1 蛋白 (4)和数多这个蛋白质的别的产品。

list all ELISA KIts 基因 基因ID UniProt
CABLES1 91768 Q8TDN4
CABLES1 63955 Q9ESJ1
大鼠 CABLES1 CABLES1 307585  

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Zebrafish Cdk5 and Abl Enzyme Substrate 1 (CABLES1) interaction partners

  1. cables1 is important for neural differentiation during embryogenesis, in a mechanism that likely involves interactions with the Cdk5 (显示 CDK5 ELISA试剂盒)/p35 (显示 CDK5R1 ELISA试剂盒) kinase pathway.

Human Cdk5 and Abl Enzyme Substrate 1 (CABLES1) interaction partners

  1. Cables1/p21 (显示 CDKN1A ELISA试剂盒) pathway has a strong effect on the induction of cell senescence and inhibition of cell growth, and acts as a novel regulatory mechanism in which p21 (显示 CDKN1A ELISA试剂盒) is probably one of several downstream effector molecules to mediate Cables1.

  2. CABLES1 is a critical regulator of corticotrope proliferation that defines a pathway often inactivated in Cushing disease

  3. the results suggest Cables1 as a novel p21 (显示 CDKN1A ELISA试剂盒) regulator through maintaining p21 (显示 CDKN1A ELISA试剂盒) stability and support the model that the tumor-suppressive function of Cables1 occurs at least in part through enhancing the tumor-suppressive activity of p21 (显示 CDKN1A ELISA试剂盒).

  4. Results illuminated a dynamic regulatory system through which activated Akt (显示 AKT1 ELISA试剂盒) and 14-3-3 (显示 YWHAQ ELISA试剂盒) work directly together to neutralize a potent tumor suppressor function of Cables1.

  5. The results did not detect a significant association. It indicated that common genetic variations in CDK5 (显示 CDK5 ELISA试剂盒) genes might not play a role in the genetic predisposition to autism.

  6. Analysis of the RT-PCR prducts of the CABLES1 gene showed eight intragenic deletions in its mRNA transcripts; 5/8 are the result of RNA splicing.

  7. Mechanisms of CABLES1 gene inactivation in ovarian cancer development are reported.

Mouse (Murine) Cdk5 and Abl Enzyme Substrate 1 (CABLES1) interaction partners

  1. Loss of Cables1 enhances tumor progression in the Apc (显示 APC ELISA试剂盒)(Min/+) mouse model and activates the Wnt (显示 WNT2 ELISA试剂盒)/beta-catenin (显示 CTNNB1 ELISA试剂盒) signaling pathway. Cables1 is a tumor suppressor gene on chromosome 18q in this in vivo mouse model.

  2. Agenesis of the corpus callosum frequency in Cables1(+/TAS (显示 MAP3K4 ELISA试剂盒)) mice was significantly lower than that in Cables1(-/TAS (显示 MAP3K4 ELISA试剂盒)) mice, indicating that wild-type Cables1 interfered with the dominant negative effect of Cables1(TAS (显示 MAP3K4 ELISA试剂盒)).

  3. Data show that oocytes lacking Cables1 exhibit lower basal levels of TAp63alpha and reduced accumulation of phosphorylated TAp63alpha in response to genotoxic stress.

  4. Cables1 null mice exhibit a significant expansion of oocyte numbers at the expense of oocyte quality throughout adulthood.

Cdk5 and Abl Enzyme Substrate 1 (CABLES1) 抗原简介

Antigen Summary

This gene encodes a protein involved in regulation of the cell cycle through interactions with several cyclin-dependent kinases. One study (PMID: 16177568) reported aberrant splicing of transcripts from this gene which results in removal of the cyclin binding domain only in human cancer cells, and reduction in gene expression was shown in colorectal cancers (PMID: 17982127).Multiple transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with CABLES1

  • Cdk5 and Abl enzyme substrate 1 (CABLES1) 抗体
  • Cdk5 and Abl enzyme substrate 1 (cables1) 抗体
  • Cdk5 and Abl enzyme substrate 1 (CpipJ_CPIJ019832) 抗体
  • CDK5 and Abl enzyme substrate 1 (Cables1) 抗体
  • Cdk5 and Abl enzyme substrate 1 (Cables1) 抗体
  • CABL1 抗体
  • Cables 抗体
  • CABLES1 抗体
  • HsT2563 抗体
  • ik3-1 抗体
  • si:dkey-2p18.3 抗体

Protein level used designations for CABLES1

Cdk5 and Abl enzyme substrate 1 , CDK5 and ABL1 enzyme substrate 1 , CDK5 and ABL1 enzyme substrate 1-like , interactor with CDK3 1 , cdk3-binding protein ik3-1 , interactor-1 with cdk3

GENE ID SPECIES
455335 Pan troglodytes
100059359 Equus caballus
100126070 Danio rerio
100345850 Oryctolagus cuniculus
100479459 Ailuropoda melanoleuca
6054063 Culex quinquefasciatus
100562423 Anolis carolinensis
100603520 Nomascus leucogenys
91768 Homo sapiens
63955 Mus musculus
768914 Gallus gallus
100682687 Canis lupus familiaris
100526114 Sus scrofa
100138286 Bos taurus
307585 Rattus norvegicus
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