Use your antibodies-online credentials, if available.
The protein encoded by COMP is a noncollagenous extracellular matrix (ECM) protein. 再加上，我们可以发COMP 抗体 (124) 和 COMP 蛋白 (21)和数多这个蛋白质的别的产品。
Showing 10 out of 70 products:
Human COMP ELISA Kit for Sandwich ELISA - ABIN414485
Liu, Li, Wei, Meng, Ren, Zhang, Yu, Huang: Genetic analysis and serum level of cartilage oligomeric matrix protein in patients with pseudoachondroplasia. in Chinese medical journal 2010
The aims of this study were to investigate the proteomic composition of injured tendons during early and late disease stages to identify disease-specific cleavage patterns of the extracellular matrix protein cartilage oligomeric matrix protein (COMP).
The present results suggest that not only type III collagen (显示 COL3A1 ELISA试剂盒) but also cartilage oligomeric matrix protein is involved in the repair and remodeling processes of the digital flexor tendon.
Within the limitations of the study design, production of COMP during healing of skin wounds does not appear to be influenced by wound type or anatomic site, nor does it appear to be correlated with TGF-beta1 (显示 TGFB1 ELISA试剂盒) concentrations.
COMP concentrations in digital flexor tendon sheath synovial fluid were significantly greater than those in normal horses with noninfected tenosynovitis caused by intrathecal tendon/ligament tearing, but not by other lesions.
The present study indicates that dynamic in vivo compression at high load and frequency lowers matrix content of COMP in the articular cartilage of the third carpal bone.
Data show that a rare missense variant in the COMP gene (cartilage oligomeric matrix protein) and a frameshift variant in the CHADL gene (chondroadherin-like protein) strongly associate with osteoarthritis total hip replacement.
COMP is a novel biomarker in breast cancer, which contributes to the severity of the disease by metabolic switching and increasing invasiveness and tumor cell viability, leading to reduced survival in animal models and human patients.
The average sCOMP level was highest among the controls and lowest among the infected children. In the juvenile idiopathic arthritis patients, the level of sCOMP was not associated with the level of CRP (显示 CRP ELISA试剂盒) or with clinical signs of disease activity.
COMT (显示 COMT ELISA试剂盒) Val158Met polymorphism may influence responses to dextromethorphan (30 mg/d) by decreasing depressive symptoms in BD patients.
The serum COMP level has the potential to be used as a biological marker for differentiating between patients with rheumatoid arthritis and healthy individuals.
The current study expanded the mutation spectrum of the COMP gene, and contributes to the understanding of phenotype/genotype of COMPassociated diseases.
In the absence of ultrasonographic knee cartilage deformation, the response of serum lubricin (显示 PRG4 ELISA试剂盒) and COMP following acute vigorous exercise indicates an increase in joint lubrication and cartilage metabolism, respectively, which appears largely independent of exercise modality.
Running appears to decrease knee intra-articular pro-inflammatory cytokine concentration and facilitates the movement of COMP from the joint space to the serum.
Results suggest that serum oligomeric matrix protein and hyaluronic acid (COMP and HA) concentrations can be used to predict early cartilage lesions in the knee.
Serum COMP levels are predictive of subsequent structural changes and incidence of painful knee osteoarthritis.
COMP could normally have a protective role against PASMC phenotype switching
these findings revealed the essential role of COMP in retarding the development of vascular aging and vascular smooth muscle cell senescence.
COMP deficiency drove macrophages toward the atherogenic phenotype and thereby aggravated atherosclerotic calcification.
COMP forms a complex with collagens intracellularly that is a prerequisite for collagen secretion.
COMP-Ang1 (显示 ANGPT1 ELISA试剂盒) can enhance BMP2 (显示 BMP2 ELISA试剂盒)-induced cranial bone regeneration with increased pericyte recruitment. Combined delivery of the proteins might be a therapeutic strategy to repair cranial bone damage.
COMP deficiency shortened tail-bleeding and clotting time and accelerated ferric-chloride-induced thrombosis. COMP specifically inhibited thrombin-induced platelet aggregation, activation, and retraction and the thrombin-mediated cleavage of fibrinogen.
COMP immunoreactivity was observed in about half of the investigated plaques from the ApoE (显示 APOE ELISA试剂盒) null mice, mainly located along the intima-medial border. Plaques in the brachiocephalic artery from ApoE (显示 APOE ELISA试剂盒) mice lacking COMP were increased in size with 54%.
study will facilitate better awareness of the differential diagnoses that might be associated with the PSACH/MED spectrum and subsequent care of PSACH/MED patients
The lack of arthritis, together with high levels of COMP-specific antibodies, in COMP-deficient mice indicates that susceptibility to arthritis is COMP specific and that endogenous expression of COMP in wild-type mice tolerizes B cells in vivo.
results imply that COMP is not a key upstream mediator of the anabolic effects of ML on the skeleton.
COMP synthesis is differentially regulated by TGFbeta1 (显示 TGFB1 ELISA试剂盒) in the surface and middle zones of bovine articular cartilage.
role for proteinases other than MMPs in the degradation of COMP in cartilage
COMP mutant expression in tendon fibroblasts leads to increased apoptotic cell death irrespective of the secretory characteristics of mutant COMP
COMP mRNA expression level was markedly increased by ball oscillation.
COMP acts as a catalyst in collagen fibrillogenesis.
The protein encoded by this gene is a noncollagenous extracellular matrix (ECM) protein. It consists of five identical glycoprotein subunits, each with EGF-like and calcium-binding (thrombospondin-like) domains. Oligomerization results from formation of a five-stranded coiled coil and disulfides. Binding to other ECM proteins such as collagen appears to depend on divalent cations. Mutations can cause the osteochondrodysplasias pseudochondroplasia (PSACH) and multiple epiphyseal dysplasia (MED).
cartilage oligomeric matrix protein
, cartilage oligomeric matrix protein (pseudoachondroplasia, epiphyseal dysplasia 1, multiple)
, cartilage oligomeric matrix protein(pseudoachondroplasia, epiphyseal dysplasia 1, multiple)
, pseudoachondroplasia (epiphyseal dysplasia 1, multiple)
, putative cartilage oligomeric matrix protein