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Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. 再加上，我们可以发Carbonic Anhydrase IX 试剂盒 (45) 和 Carbonic Anhydrase IX 蛋白 (22)和数多这个蛋白质的别的产品。
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Dog (Canine) Polyclonal CA9 Primary Antibody for ChIP, ELISA - ABIN151877
Kaidi, Moorghen, Williams, Paraskeva: Is the downregulation of EphB2 receptor expression during colorectal tumorigenesis due to hypoxia? in Gut 2007
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Human Polyclonal CA9 Primary Antibody for EIA, WB - ABIN358546
Grabmaier, A de Weijert, Verhaegh, Schalken, Oosterwijk: Strict regulation of CAIX(G250/MN) by HIF-1alpha in clear cell renal cell carcinoma. in Oncogene 2004
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Human Monoclonal CA9 Primary Antibody for CyTOF, ELISA - ABIN4287748
Cai, Alshehri, Choksi, Pestronk: Regional ischemic immune myopathy: a paraneoplastic dermatomyopathy. in Journal of neuropathology and experimental neurology 2014
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Human Polyclonal CA9 Primary Antibody for FACS, IF - ABIN390041
Hedley, Pintilie, Woo, Morrison, Birle, Fyles, Milosevic, Hill: Carbonic anhydrase IX expression, hypoxia, and prognosis in patients with uterine cervical carcinomas. in Clinical cancer research : an official journal of the American Association for Cancer Research 2003
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Human Polyclonal CA9 Primary Antibody for WB - ABIN390038
Kaluzová, Kaluz, Lerman, Stanbridge: DNA damage is a prerequisite for p53-mediated proteasomal degradation of HIF-1alpha in hypoxic cells and downregulation of the hypoxia marker carbonic anhydrase IX. in Molecular and cellular biology 2004
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Human Monoclonal CA9 Primary Antibody for FACS, ELISA - ABIN1724882
Pinheiro, Sousa, Albergaria, Paredes, Dufloth, Vieira, Schmitt, Baltazar: GLUT1 and CAIX expression profiles in breast cancer correlate with adverse prognostic factors and MCT1 overexpression. in Histology and histopathology 2011
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Human Polyclonal CA9 Primary Antibody for IF (p), IHC (p) - ABIN752773
Gogiraju, Xu, Bochenek, Steinbrecher, Lehnart, Wenzel, Kessel, Zeisberg, Dobbelstein, Schäfer: Endothelial p53 deletion improves angiogenesis and prevents cardiac fibrosis and heart failure induced by pressure overload in mice. in Journal of the American Heart Association 2015
Human Monoclonal CA9 Primary Antibody for FACS - ABIN4897691
McIntyre, Patiar, Wigfield, Li, Ledaki, Turley, Leek, Snell, Gatter, Sly, Vaughan-Jones, Swietach, Harris: Carbonic anhydrase IX promotes tumor growth and necrosis in vivo and inhibition enhances anti-VEGF therapy. in Clinical cancer research : an official journal of the American Association for Cancer Research 2012
Human Monoclonal CA9 Primary Antibody for FACS, IHC - ABIN2452557
Wang, Cheng, Liu, Zhang, Li, Li: CREB is a key negative regulator of carbonic anhydrase IX (CA9) in gastric cancer. in Cellular signalling 2015
Loss of Function Screening Reveals Carbonic Anhydrase IX as a Key Modulator of Tumor Initiating Potential in Primary Pancreatic Tumors.
constitutive activation of the NF-kappaB (显示 NFKB1 抗体) pathway in CAIX-depleted cells restored G-CSF (显示 CSF3 抗体) secretion
Downregulation of carbonic anhydrase IX promotes Col10a1 (显示 COL10A1 抗体) expression in chondrocytes.
CA IX may directly or indirectly play novel functions in brain tissue.
Data show that CA9, GLUT1 (显示 SLC2A1 抗体) and LOX (显示 LOX 抗体) mRNA levels were equally and strongly correlated to hypoxic extent in FaDudd, and the same profile was observed for CA9 and GLUT1 (显示 SLC2A1 抗体), but not LOX (显示 LOX 抗体), in SCCVII tumors.
a novel role for CA IX in the regulation of immunologic processes and digestion
although CA IX-deficiency is not a tumor-promoting factor per se, it induces glandular atrophy in the body mucosa, a lesion which is considered to be a preneoplastic alteration in the stomach
These results suggest that the loss of function of cytosolic CA II (显示 CA2 抗体) in the stomach of Car2 (显示 CA2 抗体)-/- mice leads to up-regulation of an extracellular CA, namely CA IX, which is expressed on the cell surface of the gastric epithelium.
CA9 may regulate ion and pH homeostasis within the developing embryo.
CA9 has chaperone-like functions and CA9 shed from tumors may play a direct role in stimulating an adaptive immune response
Increased miR (显示 MLXIP 抗体)-210 and concomitant decreased ISCU (显示 ISCU 抗体) RNA levels were found in ~40% of tumors and this was significantly associated with HIF-1alpha (显示 HIF1A 抗体) and CAIX, but not MCT1 (显示 CMA1 抗体) or MCT4 (显示 SLC16A4 抗体), over-expression.
describe the identification of the structural determinants responsible for the CA IX/CAND1 (显示 CAND1 抗体) interaction
Data suggest that CAIX (carbonic anhydrase IX) is a novel downstream mediator of asTF (alternatively spliced tissue factor (显示 F3 抗体)) in pancreatic ductal adenocarcinoma, particularly under hypoxic conditions that model late-stage tumor microenvironment; tumor hypoxia appears to lead to up-regulation of CAIX expression (or 'activation'), which is more pronounced in tumor cells overexpressing asTF.
Our findings suggest that LCN2 (显示 LCN2 抗体) suppresses tumour metastasis by targeting the transcriptional and post-transcriptional regulation of CAIX in oral squamous cell carcinoma
CA II (显示 CA2 抗体) and CA XII, but not CA VII (显示 CA7 抗体) or CA IX, could be useful in predicting survival in colorectal carcinomas
The findings suggest that CA9, and particularly its carbonic anhydrase activity, promotes the tumorigenicity of adult T-cell leukemia/lymphoma-derived cells and may be involved in malignant development of lymphoma-type adult T-cell leukemia/lymphoma.
We demonstrated that the expression levels of glycolysis-related proteins glucose transporter 1 (显示 SLC2A1 抗体), hexokinase II, carbonic anhydrase IX, and monocarbonylate transporter 4 differ between thyroid cancer subtypes and are correlated with poorer prognosis
CAIX and PTEN (显示 PTEN 抗体) had prognostic importance for metastatic renal cell carcinoma (显示 MOK 抗体) patients receiving first-line VEGFR (显示 KDR 抗体) TKI. Future validation and mechanistic studies are required.
combined HIF1alpha (显示 HIF1A 抗体) and CAIX protein expression may serve as an unfavorable prognostic indicator particularly in patients treated with cyclophosphamide-based chemotherapy or radiotherapy as well as those with basal phenotype of breast cancer
CA9 may have a role in castration-resistant prostate cancer progression
Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. CA IX is a transmembrane protein and the only tumor-associated carbonic anhydrase isoenzyme known. It is expressed in all clear-cell renal cell carcinoma, but is not detected in normal kidney or most other normal tissues. It may be involved in cell proliferation and transformation. This gene was mapped to 17q21.2 by fluorescence in situ hybridization, however, radiation hybrid mapping localized it to 9p13-p12.
carbonic anhydrase IX
, carbonic anhydrase 9
, carbonate dehydratase IX
, membrane antigen MN homolog
, RCC-associated antigen G250
, RCC-associated protein G250
, carbonic dehydratase
, membrane antigen MN
, renal cell carcinoma-associated antigen G250