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The protein encoded by CDKAL1 is a member of the methylthiotransferase family. 再加上，我们可以发CDKAL1 抗体 (42) 和 CDKAL1 蛋白 (4)和数多这个蛋白质的别的产品。
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family-based GWAS of imputed SNPs revealed novel genomic variants in (or near) PTPRG (显示 PTPRG ELISA试剂盒), OSBPL6 (显示 OSBPL6 ELISA试剂盒), and PDCL3 (显示 PDCL3 ELISA试剂盒) that influence risk for Alzheimer's Disease. rs7609954 in the gene PTPRG (显示 PTPRG ELISA试剂盒), rs1347297 in the gene OSBPL6 (显示 OSBPL6 ELISA试剂盒), and rs1513625 near PDCL3 (显示 PDCL3 ELISA试剂盒). In addition, rs72953347 in OSBPL6 (显示 OSBPL6 ELISA试剂盒) and two SNPs in the gene CDKAL1 showed marginally significant association with LOAD (rs10456232, P-value=4.76 x 10-7; rs62400067, P-value=3.54 x 10-7).
The multivariate logistic regression analysis with reference to both alleles and genotypes of CDKAL1 SNPs showed significant association, suggesting an important role for this gene in the T2DM pathophysiology. INTERPRETATION & CONCLUSIONS: A significant association was seen of all the three SNPs of CDKAL1 and CDKN2A/B genes with T2DM but none of the two SNPs of HHEX (显示 HHEX ELISA试剂盒).
Study provides evidence that SNPs of JMJD1C and KCNQ1 (显示 KCNQ1 ELISA试剂盒) are prospectively associated with the risk of type 2 diabetes (T2D) in Korean population. Additionally, CDKAL1 may not be associated with T2D onset over the age of 40.
Our results suggest that rs6908425 in CDKAL1 is associated with the risk of developing SAPHO in Han Chinese populations. People who carry the risk allele T of rs6908425 might be more prone to developing SAPHO syndrome.
We investigated the association between 8 single-nucleotide polymorphisms (SNPs) at 3 genetic loci (CDKAL1, CDKN2A/2B and FTO (显示 FTO ELISA试剂盒)) with type 2 diabetes (T2D) in a Uyghur population
our data suggested that CDKAL1 gene variants have a significant effect on the response to anti-TNF (显示 TNF ELISA试剂盒) therapies among Psoriasis patients
Risk alleles for 6 loci increased glucose levels from birth to 5 years of age (ADCY5 (显示 ADCY5 ELISA试剂盒), ADRA2A (显示 ADRA2A ELISA试剂盒), CDKAL1, CDKN2A/B, GRB10 (显示 GRB10 ELISA试剂盒), and TCF7L2 (显示 TCF7L2 ELISA试剂盒)
rs10946398 associated with markers of impaired insulin (显示 INS ELISA试剂盒) secretion
We observed novel selection signals in CDKAL1 and NEGR1 (显示 NEGR1 ELISA试剂盒), well-known diabetes and obesity susceptibility genes
study found SNP rs7754840 in CDKAL1, rs864745 in JAZF1 (显示 JAZF1 ELISA试剂盒), and rs35767 in IGF1 (显示 IGF1 ELISA试剂盒) might serve as potential susceptibility loci for type 2 diabetes in the Uyghur population
CDKAL1 may affect such compensatory mechanisms regulating glucose homeostasis through interaction with diet
Knockout mice with pancreatic beta-cell-specific lack of cdkal1 show pancreatic islet hypertrophy and impaired blood glucose control.
Data show that Cdkal1 is a mammalian methylthiotransferase that biosynthesizes 2-methylthio-N6-threonylcarbamoyladenosine (ms2t6A) in tRNA(Lys (显示 LYZ ELISA试剂盒))(UUU) and that it is required for the accurate translation of AAA (显示 AAAS ELISA试剂盒) and AAG codons.
CDKAL1 controls first-phase insulin (显示 INS ELISA试剂盒) exocytosis in beta cells by facilitating ATP generation, K(ATP) channel responsiveness and the subsequent activity of Ca(2 (显示 CA2 ELISA试剂盒)+) channels through pathways other than CDK5 (显示 CDK5 ELISA试剂盒)-mediated regulation
The protein encoded by this gene is a member of the methylthiotransferase family. The function of this gene is not known. Genome-wide association studies have linked single nucleotide polymorphisms in an intron of this gene with susceptibilty to type 2 diabetes.
CDK5 regulatory subunit-associated protein 1-like 1
, tRNA-t(6)A37 methylthiotransferase
, threonylcarbamoyladenosine tRNA methylthiotransferase
, CDK5 regulatory subunit associated protein 1-like 1