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The protein encoded by CDKAL1 is a member of the methylthiotransferase family. 再加上，我们可以发CDKAL1 蛋白 (4) 和 CDKAL1 试剂盒 (2)和数多这个蛋白质的别的产品。
Showing 10 out of 42 products:
Dog (Canine) Polyclonal CDKAL1 Primary Antibody for ELISA - ABIN451799
Zeggini, Weedon, Lindgren, Frayling, Elliott, Lango, Timpson, Perry, Rayner, Freathy, Barrett, Shields, Morris, Ellard, Groves, Harries, Marchini, Owen, Knight, Cardon, Walker, Hitman, Morris, Doney et al.: Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes. ... in Science (New York, N.Y.) 2007
Human Polyclonal CDKAL1 Primary Antibody for ELISA, WB - ABIN570672
Brambillasca, Altkrueger, Colombo, Friederich, Eickelmann, Mark, Borgese, Solimena: CDK5 regulatory subunit-associated protein 1-like 1 (CDKAL1) is a tail-anchored protein in the endoplasmic reticulum (ER) of insulinoma cells. in The Journal of biological chemistry 2012
family-based GWAS of imputed SNPs revealed novel genomic variants in (or near) PTPRG (显示 PTPRG 抗体), OSBPL6 (显示 OSBPL6 抗体), and PDCL3 (显示 PDCL3 抗体) that influence risk for Alzheimer's Disease. rs7609954 in the gene PTPRG (显示 PTPRG 抗体), rs1347297 in the gene OSBPL6 (显示 OSBPL6 抗体), and rs1513625 near PDCL3 (显示 PDCL3 抗体). In addition, rs72953347 in OSBPL6 (显示 OSBPL6 抗体) and two SNPs in the gene CDKAL1 showed marginally significant association with LOAD (rs10456232, P-value=4.76 x 10-7; rs62400067, P-value=3.54 x 10-7).
The multivariate logistic regression analysis with reference to both alleles and genotypes of CDKAL1 SNPs showed significant association, suggesting an important role for this gene in the T2DM pathophysiology. INTERPRETATION & CONCLUSIONS: A significant association was seen of all the three SNPs of CDKAL1 and CDKN2A (显示 CDKN2A 抗体)/B genes with T2DM but none of the two SNPs of HHEX (显示 HHEX 抗体).
Study provides evidence that SNPs of JMJD1C (显示 JMJD1C 抗体) and KCNQ1 (显示 KCNQ1 抗体) are prospectively associated with the risk of type 2 diabetes (T2D) in Korean population. Additionally, CDKAL1 may not be associated with T2D onset over the age of 40.
Our results suggest that rs6908425 in CDKAL1 is associated with the risk of developing SAPHO in Han Chinese populations. People who carry the risk allele T of rs6908425 might be more prone to developing SAPHO syndrome.
We investigated the association between 8 single-nucleotide polymorphisms (SNPs) at 3 genetic loci (CDKAL1, CDKN2A (显示 CDKN2A 抗体)/2B and FTO (显示 FTO 抗体)) with type 2 diabetes (T2D) in a Uyghur population
our data suggested that CDKAL1 gene variants have a significant effect on the response to anti-TNF (显示 TNF 抗体) therapies among Psoriasis patients
Risk alleles for 6 loci increased glucose levels from birth to 5 years of age (ADCY5 (显示 ADCY5 抗体), ADRA2A (显示 ADRA2A 抗体), CDKAL1, CDKN2A (显示 CDKN2A 抗体)/B, GRB10 (显示 GRB10 抗体), and TCF7L2 (显示 TCF7L2 抗体)
rs10946398 associated with markers of impaired insulin (显示 INS 抗体) secretion
We observed novel selection signals in CDKAL1 and NEGR1 (显示 NEGR1 抗体), well-known diabetes and obesity susceptibility genes
study found SNP rs7754840 in CDKAL1, rs864745 in JAZF1 (显示 JAZF1 抗体), and rs35767 in IGF1 (显示 IGF1 抗体) might serve as potential susceptibility loci for type 2 diabetes in the Uyghur population
CDKAL1 may affect such compensatory mechanisms regulating glucose homeostasis through interaction with diet
Knockout mice with pancreatic beta-cell-specific lack of cdkal1 show pancreatic islet hypertrophy and impaired blood glucose control.
Data show that Cdkal1 is a mammalian methylthiotransferase that biosynthesizes 2-methylthio-N6-threonylcarbamoyladenosine (ms2t6A) in tRNA(Lys (显示 LYZ 抗体))(UUU) and that it is required for the accurate translation of AAA (显示 AAAS 抗体) and AAG (显示 C16orf35 抗体) codons.
CDKAL1 controls first-phase insulin (显示 INS 抗体) exocytosis in beta cells by facilitating ATP generation, K(ATP) channel responsiveness and the subsequent activity of Ca(2 (显示 CA2 抗体)+) channels through pathways other than CDK5 (显示 CDK5 抗体)-mediated regulation
The protein encoded by this gene is a member of the methylthiotransferase family. The function of this gene is not known. Genome-wide association studies have linked single nucleotide polymorphisms in an intron of this gene with susceptibilty to type 2 diabetes.
CDK5 regulatory subunit-associated protein 1-like 1
, tRNA-t(6)A37 methylthiotransferase
, threonylcarbamoyladenosine tRNA methylthiotransferase
, CDK5 regulatory subunit associated protein 1-like 1