anti-CDK5 Regulatory Subunit Associated Protein 1-Like 1 (CDKAL1) 抗体

The protein encoded by CDKAL1 is a member of the methylthiotransferase family. 再加上,我们可以发CDKAL1 蛋白 (4)CDKAL1 试剂盒 (2)和数多这个蛋白质的别的产品。

列出全部抗体 基因 基因ID UniProt
CDKAL1 54901 Q5VV42
CDKAL1 68916 Q91WE6
CDKAL1 361243  

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Showing 10 out of 42 products:

产品编号 适用 宿主 标记 应用范围 图像 规格 供应商 交付 价格 详细
非结合性 ELISA, WB 100 μL Log in to see 34至38个工作日
¥4,371.67
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山羊 非结合性 ELISA, WB   100 μg Log in to see 24至29个工作日
¥9,230.97
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非结合性 IF (p), IHC (p), WB Lane 1: rat brain lysates Lane 2: rat liver lysates probed with Anti CDKAL1 Polyclonal Antibody, Unconjugated (ABIN873056) at 1:200 in 4 °C. Followed by conjugation to secondary antibody at 1:3000 90min in 37 °C. Predicted band 65kD. Observed band size: 65kD. 100 μL Log in to see 5至7个工作日
¥2,610.23
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山羊 非结合性 ELISA   0.1 mg Log in to see 25至31个工作日
¥3,333.96
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Alexa Fluor 594 IF (p)   100 μL Log in to see 14至17个工作日
¥3,555.98
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非结合性 IHC (p), IHC, WB Western Blot: CDKAL1 Antibody [NBP1-32796] - A. 30 ug Jurkat whole cell lysate/extract, B. 30 ug Raji whole cell lysate/extract, C. 30 ug K562 whole cell lysate/extract 7. 5 % SDS-PAGE gel, antibody dilution 1:1000. Western Blot: CDKAL1 Antibody [NBP1-32796] - Sample (30 ug of whole cell lysate) A:NIH-3T3 7.5% SDS PAGE diluted at 1:2000 100 μL Log in to see 25至31个工作日
¥3,655.56
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Alexa Fluor 350 IF (p)   100 μL Log in to see 14至17个工作日
¥3,555.98
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Alexa Fluor 488 IF (p)   100 μL Log in to see 14至17个工作日
¥3,555.98
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Alexa Fluor 555 IF (p)   100 μL Log in to see 14至17个工作日
¥3,555.98
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Alexa Fluor 647 IF (p)   100 μL Log in to see 14至17个工作日
¥3,555.98
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通过反应活性、应用领域、克隆类型和共轭标记 CDKAL1 抗体

特性 应用范围 宿主 克隆类型 标记
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引用最多的anti-CDKAL1 抗体

  1. Dog (Canine) Polyclonal CDKAL1 Primary Antibody for ELISA - ABIN451799 : Zeggini, Weedon, Lindgren, Frayling, Elliott, Lango, Timpson, Perry, Rayner, Freathy, Barrett, Shields, Morris, Ellard, Groves, Harries, Marchini, Owen, Knight, Cardon, Walker, Hitman, Morris, Doney et al.: Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes. ... in Science (New York, N.Y.) 2007 (PubMed)

  2. Human Polyclonal CDKAL1 Primary Antibody for ELISA, WB - ABIN570672 : Brambillasca, Altkrueger, Colombo, Friederich, Eickelmann, Mark, Borgese, Solimena: CDK5 regulatory subunit-associated protein 1-like 1 (CDKAL1) is a tail-anchored protein in the endoplasmic reticulum (ER) of insulinoma cells. in The Journal of biological chemistry 2012 (PubMed)

更多抗CDKAL1的相互作用对抗体

Human CDK5 Regulatory Subunit Associated Protein 1-Like 1 (CDKAL1) interaction partners

  1. family-based GWAS of imputed SNPs revealed novel genomic variants in (or near) PTPRG (显示 PTPRG 抗体), OSBPL6 (显示 OSBPL6 抗体), and PDCL3 (显示 PDCL3 抗体) that influence risk for Alzheimer's Disease. rs7609954 in the gene PTPRG (显示 PTPRG 抗体), rs1347297 in the gene OSBPL6 (显示 OSBPL6 抗体), and rs1513625 near PDCL3 (显示 PDCL3 抗体). In addition, rs72953347 in OSBPL6 (显示 OSBPL6 抗体) and two SNPs in the gene CDKAL1 showed marginally significant association with LOAD (rs10456232, P-value=4.76 x 10-7; rs62400067, P-value=3.54 x 10-7).

  2. The multivariate logistic regression analysis with reference to both alleles and genotypes of CDKAL1 SNPs showed significant association, suggesting an important role for this gene in the T2DM pathophysiology. INTERPRETATION & CONCLUSIONS: A significant association was seen of all the three SNPs of CDKAL1 and CDKN2A (显示 CDKN2A 抗体)/B genes with T2DM but none of the two SNPs of HHEX (显示 HHEX 抗体).

  3. Study provides evidence that SNPs of JMJD1C (显示 JMJD1C 抗体) and KCNQ1 (显示 KCNQ1 抗体) are prospectively associated with the risk of type 2 diabetes (T2D) in Korean population. Additionally, CDKAL1 may not be associated with T2D onset over the age of 40.

  4. Our results suggest that rs6908425 in CDKAL1 is associated with the risk of developing SAPHO in Han Chinese populations. People who carry the risk allele T of rs6908425 might be more prone to developing SAPHO syndrome.

  5. We investigated the association between 8 single-nucleotide polymorphisms (SNPs) at 3 genetic loci (CDKAL1, CDKN2A (显示 CDKN2A 抗体)/2B and FTO (显示 FTO 抗体)) with type 2 diabetes (T2D) in a Uyghur population

  6. our data suggested that CDKAL1 gene variants have a significant effect on the response to anti-TNF (显示 TNF 抗体) therapies among Psoriasis patients

  7. Risk alleles for 6 loci increased glucose levels from birth to 5 years of age (ADCY5 (显示 ADCY5 抗体), ADRA2A (显示 ADRA2A 抗体), CDKAL1, CDKN2A (显示 CDKN2A 抗体)/B, GRB10 (显示 GRB10 抗体), and TCF7L2 (显示 TCF7L2 抗体)

  8. rs10946398 associated with markers of impaired insulin (显示 INS 抗体) secretion

  9. We observed novel selection signals in CDKAL1 and NEGR1 (显示 NEGR1 抗体), well-known diabetes and obesity susceptibility genes

  10. study found SNP rs7754840 in CDKAL1, rs864745 in JAZF1 (显示 JAZF1 抗体), and rs35767 in IGF1 (显示 IGF1 抗体) might serve as potential susceptibility loci for type 2 diabetes in the Uyghur population

Mouse (Murine) CDK5 Regulatory Subunit Associated Protein 1-Like 1 (CDKAL1) interaction partners

  1. CDKAL1 may affect such compensatory mechanisms regulating glucose homeostasis through interaction with diet

  2. Knockout mice with pancreatic beta-cell-specific lack of cdkal1 show pancreatic islet hypertrophy and impaired blood glucose control.

  3. Data show that Cdkal1 is a mammalian methylthiotransferase that biosynthesizes 2-methylthio-N6-threonylcarbamoyladenosine (ms2t6A) in tRNA(Lys (显示 LYZ 抗体))(UUU) and that it is required for the accurate translation of AAA (显示 AAAS 抗体) and AAG (显示 C16orf35 抗体) codons.

  4. CDKAL1 controls first-phase insulin (显示 INS 抗体) exocytosis in beta cells by facilitating ATP generation, K(ATP) channel responsiveness and the subsequent activity of Ca(2 (显示 CA2 抗体)+) channels through pathways other than CDK5 (显示 CDK5 抗体)-mediated regulation

CDKAL1 抗原简介

蛋白简介

The protein encoded by this gene is a member of the methylthiotransferase family. The function of this gene is not known. Genome-wide association studies have linked single nucleotide polymorphisms in an intron of this gene with susceptibilty to type 2 diabetes.

Gene names and symbols associated with CDKAL1

  • CDK5 regulatory subunit associated protein 1-like 1 (CDKAL1) 抗体
  • CDK5 regulatory subunit associated protein 1-like 1 (cdkal1) 抗体
  • CDK5 regulatory subunit associated protein 1-like 1 (Cdkal1) 抗体
  • 1190005B03Rik 抗体
  • 6620401C13Rik 抗体
  • MGC76088 抗体
  • MGC78779 抗体
  • zgc:65864 抗体

Protein level used designations for CDKAL1

CDK5 regulatory subunit-associated protein 1-like 1 , tRNA-t(6)A37 methylthiotransferase , threonylcarbamoyladenosine tRNA methylthiotransferase , CDK5 regulatory subunit associated protein 1-like 1

GENE ID SPECIES
100052309 Equus caballus
393600 Danio rerio
394802 Xenopus (Silurana) tropicalis
420823 Gallus gallus
432014 Xenopus laevis
530159 Bos taurus
587594 Strongylocentrotus purpuratus
747778 Pan troglodytes
100024680 Monodelphis domestica
54901 Homo sapiens
488240 Canis lupus familiaris
68916 Mus musculus
361243 Rattus norvegicus
100512355 Sus scrofa
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