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Cd2ap encodes a scaffolding molecule that regulates the actin cytoskeleton. 再加上，我们可以发CD2-Associated Protein 抗体 (46) 和 CD2-Associated Protein 蛋白 (7)和数多这个蛋白质的别的产品。
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Tank1 (显示 TNKS ELISA试剂盒)/Tank2 (显示 TNKS2 ELISA试剂盒) inhibition aggravates kidney injury in the absence of CD2AP.
data suggest that CD2AP acts as a negative regulator of ICAM-1 (显示 ICAM1 ELISA试剂盒) clustering, which limits the formation of ICAM-1 (显示 ICAM1 ELISA试剂盒) adhesion complexes to prevent uncontrolled neutrophil adhesion and transcellular transmigration.
CD2AP expression in renal tubules may histologically associate with tissue hypoxia and reflected recovery from CsA-mediated renal injury in nephrotic syndrome patients.
data thus reveal a Golgi-traversing pathway for exosomal release of the cargo protein GPRC5B (显示 GPRC5B ELISA试剂盒) in which CD2AP facilitates the entry and LMAN2 (显示 LMAN2 ELISA试剂盒) impedes the exit of the flux, respectively.
Silencing Cindr in nephrocytes led to dramatic nephrocyte functional impairment and shortened life span, as well as collapse of nephrocyte lacunar channels and effacement of nephrocyte slit diaphragms. These phenotypes could be rescued by expression of a wild-type human CD2AP gene, but not a mutant allele derived from a patient with CD2AP-associated NS.
Study found a novel association of CD2AP with plasma homocysteine in participants with African ancestry and found a new variant in the candidate gene CBS (显示 CBS ELISA试剂盒) associated with homocysteine
CD2AP rs9349407 polymorphism contributes to Alzheimer's disease susceptibility.
discovered novel interaction candidates for CD2AP and characterized subtle yet significant differences in the recognition preferences of its three SH3 domains for c-CBL (显示 CBL ELISA试剂盒), ALIX (显示 PDCD6IP ELISA试剂盒), and RIN3 (显示 RIN3 ELISA试剂盒)
we present the first demonstration that the purified SH3 domains of the CD2AP/Cin85 (显示 SH3KBP1 ELISA试剂盒) protein family are able to directly bind the p53 (显示 TP53 ELISA试剂盒) protein, and to discriminate between the two polymorphic variants P72R
CD2-Associated Protein affects Abeta (显示 APP ELISA试剂盒) levels and Abeta42/Abeta40 ratio in vitro
CD2AP gene variants may contribute to susceptibility to end-stage renal disease in patients with type 1 diabetes.
Bin1 (显示 BIN1 ELISA试剂盒) and CD2AP keep APP (显示 APP ELISA试剂盒) and BACE1 (显示 BACE ELISA试剂盒) apart in early endosomes by distinct mechanisms in axon and dendrites. Individuals carrying variants of either factor would slowly accumulate Abeta (显示 APP ELISA试剂盒) in neurons increasing the risk for late-onset AD.
CD2AP forms a complex with GGA2 (显示 GGA2 ELISA试剂盒), a clathrin adaptor, which sorts Glut4 (显示 SLC2A4 ELISA试剂盒) to GSVs, suggesting a role for CD2AP in this process.
CD2AP is the first signaling molecule associated with adult sensory axonal collateral sprouting
CD2AP has role in mediating blood-brain barrier integrity and cerebrovascular roles of CD2AP could contribute to its effects on Alzheimer's disease risk.
only the SH3 domains of CD2AP are necessary to enhance the E3 ligase activity of Cbl-3 (显示 CBLC ELISA试剂盒)/c toward Ret51 (显示 RET ELISA试剂盒)
CD2AP is not involved in the regulation of type I IFNs in plasmacytoid dendritic cells. Its major function is on the actin cytoskeleton, affecting migration to local lymph nodes under conditions of inflammation.
CD2AP deficiency results in the excretion of intact albumin (显示 ALB ELISA试剂盒) in knockout mice.
the formation of lamellipodia is mediated by a complex of cortactin (显示 CTTN ELISA试剂盒), CD2AP, and actin capping protein (显示 TMOD4 ELISA试剂盒)
This gene encodes a scaffolding molecule that regulates the actin cytoskeleton. The protein directly interacts with filamentous actin and a variety of cell membrane proteins through multiple actin binding sites, SH3 domains, and a proline-rich region containing binding sites for SH3 domains. The cytoplasmic protein localizes to membrane ruffles, lipid rafts, and the leading edges of cells. It is implicated in dynamic actin remodeling and membrane trafficking that occurs during receptor endocytosis and cytokinesis. Haploinsufficiency of this gene is implicated in susceptibility to glomerular disease.
, Cas ligand with multiple Src homology 3 (SH3) domains
, adapter protein CMS
, cas ligand with multiple SH3 domains
, hypothetical protein
, SH3 domain-containing adapter protein
, SH3 domain-containing adaptor protein METS-1
, mesenchyme to epithelium transition protein, SH3 domains
, mesenchyme-to-epithelium transition protein with SH3 domains 1