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CD244 encodes a cell surface receptor expressed on natural killer (NK) cells (and some T cells) that mediate non-major histocompatibility complex (MHC) restricted killing. 再加上，我们可以发CD244 抗体 (134) 和 CD244 蛋白 (27)和数多这个蛋白质的别的产品。
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The present study provides further insights into the role of the 2B4-CD48 (显示 CD48 ELISA试剂盒) interaction in the fine regulation of CD8 (显示 CD8A ELISA试剂盒)(+) T-cell effector function upon antigenic stimulation.
Data show that 2B4 not only can bind to CD48 (显示 CD48 ELISA试剂盒) in trans but also interacts with CD48 (显示 CD48 ELISA试剂盒) in cis (显示 CISH ELISA试剂盒) by using the same binding interface. Also, the results demonstrated that constitutive phosphorylation of 2B4 occurs only in the presence of CD48 (显示 CD48 ELISA试剂盒), and that cis (显示 CISH ELISA试剂盒) binding is sufficient to induce substantial levels of baseline phosphorylation.
2B4 expression is increased on CD4 (显示 CD4 ELISA试剂盒)+ T cells in septic patients
Self-iNKR(-) NK cells in X-linked lymphoproliferative disease 1 patients are functional even in resting conditions, suggesting a role of the inhibitory 2B4/CD48 (显示 CD48 ELISA试剂盒) pathway in the education process during NK-cell maturation.
our results provide strong evidence that CD244 co-operates with c-Kit (显示 KIT ELISA试剂盒) to regulate leukemogenesis through SHP-2 (显示 PTPN11 ELISA试剂盒)/p27 (显示 PAK2 ELISA试剂盒) signaling.
SLAMF4 gene and surface protein expression was down-regulated in CD8 (显示 CD8A ELISA试剂盒)+ T cells from SLE patients compared with that in cells obtained from healthy donors. SLAMF4+ effector memory cells produced more granzyme B (显示 Gzmb ELISA试剂盒) and perforin (显示 PRF1 ELISA试剂盒) than SLAMF4- cells.
GSK-3 (显示 GSK3b ELISA试剂盒) undergoes inhibitory phosphorylation at regulatory serine residues by the engagement of NKG2D (显示 KLRK1 ELISA试剂盒) and 2B4, either individually or in combination.
Cytomegalovirus-Induced Expression of CD244 after Liver Transplantation Is Associated with CD8 (显示 CD8A ELISA试剂盒)+ T Cell Hyporesponsiveness to Alloantigen
CD8 (显示 CD8A ELISA试剂盒)(+) T cells require 2B4 for Epstein-Barr virus-specific immune control, because 2B4 blockade after CD8 (显示 CD8A ELISA试剂盒)(+) T-cell depletion did not further aggravate symptoms of the infection.
CD244 expression/signaling in tuberculosis correlates with high levels of a long noncoding RNA (lncRNA)-BC050410 [named as lncRNA-AS-GSTT1(1 (显示 GSTT1 ELISA试剂盒)-72) or lncRNA-CD244] in the CD244(+)CD8 (显示 CD8A ELISA试剂盒)(+) T-cell subpopulation.
2B4 expression is increased on CD4 (显示 CD4 ELISA试剂盒)+ T cells in septic animals
2B4 dampens T-independent B cell responses.
DCs from CD244(-/-) mice elicited increased NK cell activation in vitro. These data add CD244 to a growing list of immuno-modulatory receptors found on DCs.
Data show that enforced expression of inhibitor of differentiation protein Id3 (显示 ID3 ELISA试剂盒) specifically increased the persistence of Cd244 protein 2B4(+) virus-specific CD8 (显示 CD8A ELISA试剂盒)(+) T cells.
Molecular dynamic simulation explains unbinding and unfolding of CD48 (显示 CD48 ELISA试剂盒)-2B4 protein complexes.
Signaling via SLAMF4 controls expansion of cytotoxic CD8alphabeta(+) IELs, which regulate the reversible depletion of lamina propria phagocytes and inflammation in the small intestine.
CD244 (2B4) has a regulatory effect on mast cells and eosinophils in murine allergic inflammation.
NKG2D (显示 KLRK1 ELISA试剂盒) ligation relieves 2B4-mediated NK-cell self-tolerance in mice.
blockade of CD28 (显示 CD28 ELISA试剂盒) signals in the presence of preserved CTLA-4 (显示 CTLA4 ELISA试剂盒) signals results in the unique up-regulation of 2B4 on primary CD8 (显示 CD8A ELISA试剂盒)(+) effectors, and that this 2B4 expression plays a critical functional role in controlling antigen-specific T8 cell responses
In the absence of SAP (显示 APCS ELISA试剂盒), signaling through the SLAM (显示 SLAMF1 ELISA试剂盒) family members Ly108 (显示 SLAMF6 ELISA试剂盒) and 2B4 resulted in increased recruitment of the SHP-1 (显示 PTPN6 ELISA试剂盒) phosphatase, associated with altered SHP-1 (显示 PTPN6 ELISA试剂盒) localization and decreased activation of Src (显示 SRC ELISA试剂盒) kinases at the synapse.
This gene encodes a cell surface receptor expressed on natural killer (NK) cells (and some T cells) that mediate non-major histocompatibility complex (MHC) restricted killing. The interaction between NK-cell and target cells via this receptor is thought to modulate NK-cell cytolytic activity. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
CD244 molecule, natural killer cell receptor 2B4
, natural killer cell receptor 2B4
, NK cell activation inducing ligand NAIL
, NK cell activation-inducing ligand
, NK cell type I receptor protein 2B4
, SLAM family member 4
, signaling lymphocytic activation molecule 4
, CD244 natural killer cell receptor 2B4
, non MHC restricted killing associated
, non-MHC restricted killing associated
, transmembrane NK cell receptor 2B4
, NK cell receptor 2B4