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CD1B encodes a member of the CD1 family of transmembrane glycoproteins, which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. 再加上，我们可以发CD1b 抗体 (207) 和 CD1b 蛋白 (11)和数多这个蛋白质的别的产品。
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The crystal structure of CD1b3 has been determined in complex with endogenous ligands, identified as a mixture of phosphatidylcholine (显示 SGMS1 ELISA试剂盒) and phosphatidylethanolamine, and the ability of the protein to bind mycobacterial glycolipids has been analyzed.
These results underscore substantial conservation of the group 1 CD1 system between humans and rhesus macaque monkeys.
the development of polyvalent complexes of CD1b proteins and carbohydrate backbones (dextramers) and their use in identifying CD1b autoreactive T cells from human donors.
[review] Humans express both Group 1 (CD1a, CD1b and CD1c) and Group 2 (CD1d) CD1 molecules with nonredundant functions in response to the presentation of endogenous lipids.
for isoforms CD1b through CD1e (显示 CD1e ELISA试剂盒), our simulations show the near-complete collapse of the hydrophobic cavities in the absence of the antigen. This event results from the spontaneous closure of the binding domain entrance, flanked by two alpha-helices.
Dysregulated CD1 (显示 CD1A ELISA试剂盒) profile in myeloid dendritic cells in CVID (显示 TNFRSF13B ELISA试剂盒) is normalized by IVIg treatment.
Molecular mechanisms by which CD1b captures distinct classes of self- and mycobacterial antigens are reviewed. Review.
Deciphering the role of CD1e (显示 CD1e ELISA试剂盒) protein in mycobacterial phosphatidyl-myo (显示 SYNPO2 ELISA试剂盒)-inositol mannosides (PIM (显示 PIM1 ELISA试剂盒)) processing for presentation by CD1b to T lymphocytes
CD1b has a mechanism for presenting either two small or one large lipid, allowing presentation of antigens with an unusually broad range of chain lengths.
a cognate mechanism whereby CD1b-glycolipid complexes bind to TCRs.
The DC-SIGNlow/CD86high population is characterized by a reduced CD1b expression that correlates with a reduced iMtb-specific lymphocyte proliferation together with an enhanced mixed leukocyte reaction.
gammadelta T cells recognize lipid A (LA) in a CD1b- or CD1c-restricted manner in first response against Gram-bacteria, while the interaction between TLR4 (显示 TLR4 ELISA试剂盒) on gammadelta T cells and LA might strengthen the subsequent response of gammadelta T cells.
This gene encodes a member of the CD1 family of transmembrane glycoproteins, which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. The human genome contains five CD1 family genes organized in a cluster on chromosome 1. The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands. The protein encoded by this gene localizes to late endosomes and lysosomes via a tyrosine-based motif in the cytoplasmic tail, and requires vesicular acidification to bind lipid antigens.
, CD1b molecule
, T-cell surface glycoprotein CD1b-3
, T-cell surface glycoprotein CD1c
, T-cell surface glycoprotein CD1b
, CD1b antigen
, CD1B antigen, b polypeptide
, cortical thymocyte antigen CD1B
, differentiation antigen CD1-alpha-3