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The protein encoded by CD163 is a member of the scavenger receptor cysteine-rich (SRCR) superfamily, and is exclusively expressed in monocytes and macrophages. 再加上，我们可以发CD163 抗体 (426) 和 CD163 蛋白 (15)和数多这个蛋白质的别的产品。
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Human CD163 ELISA Kit for Sandwich ELISA - ABIN1979418
Wang, Yu, Yang, Wu, Zhu, Liu, Liu, Hu, Wu, Xia, Chen: Expression of serum sCD163 in patients with liver diseases and inflammatory disorders. in International journal of clinical and experimental pathology 2015
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Human CD163 ELISA Kit for Sandwich ELISA - ABIN578184
Hedegaard, Sellebjerg, Krakauer, Hesse, Bendtzen, Nielsen: Interferon-beta increases systemic BAFF levels in multiple sclerosis without increasing autoantibody production. in Multiple sclerosis (Houndmills, Basingstoke, England) 2011
Mouse (Murine) CD163 ELISA Kit for Sandwich ELISA - ABIN425050
Mukai, Komatsu, Nakajima, Urai, Nasruddin, Sugama, Nakatani: The effect of 17?-estradiol on cutaneous wound healing in protein-malnourished ovariectomized female mouse model. in PLoS ONE 2014
house dust mite -challenged Cd163-/- mice displayed increases in airway eosinophils and mucous cell metaplasia
In diabetic mice, increased sCD163 at wk 5 and decreased percentage of CD163(+) monocytes at wk 10 preceded alteration in kidney collagen IV mRNA at wk 20. In vitro incubation of monocytes in anti-inflammatory glucocorticoid increased the percentage of CD163(+) monocytes.
During ischaemia, soluble CD163 functions as a decoy receptor for TWEAK (显示 TNFSF12 ELISA试剂盒), to regulate TWEAK (显示 TNFSF12 ELISA试剂盒)-induced activation of canonical nuclear factor-kappaB and Notch (显示 NOTCH1 ELISA试剂盒) signalling necessary for myogenic progenitor cell proliferation.
Data indicate an essential substrate motif for ADAM17 (显示 ADAM17 ELISA试剂盒)-mediated CD163 and proTNF-alpha cleavage in macrophages.
alpha(1)-Acid glycoprotein (显示 ORM1 ELISA试剂盒) up-regulates CD163 via TLR4 (显示 TLR4 ELISA试剂盒)/CD14 protein (显示 ERGIC2 ELISA试剂盒) pathway: possible protection against hemolysis-induced oxidative stress.
Data show that telmisartan reduced the mRNA expression of CD11c (显示 ITGAX ELISA试剂盒) and TNF-alpha (显示 TNF ELISA试剂盒), M1 macrophage markers, and significantly increased the expressions of M2 markers, such as CD163, CD209 (显示 CD209 ELISA试剂盒).
Assignment of the CD163 antigen to mouse chromosome 6 band F2.
The cumulative incidence of de novo-onset cGVHD was higher in patients with higher plasma soluble CD163 concentrations at day 80 than those with lower concentrations (75% versus 40%, P = .018). The cumulative incidence of de novo- or quiescent-onset cGVHD did not differ statistically according to concentrations of the 3 other proteins at day 80.
Although sCD163 level cannot predict the development of varices, it serves as a good predictor for the detection of size of varices (large varices), the need of prophylactic interventions, and risk of variceal bleeding. sCD163 level is a helpful indicator with the progression of cirrhosis and portal hypertension.
CD163 and ferritin (显示 FTL ELISA试剂盒) are biomarkers of functional outcomes in intracerebral hemorrhage.
the simultaneous detection of both plasma sCD14 and IL-6 (显示 IL6 ELISA试剂盒) is a promising diagnostic approach to identify active pulmonary tuberculosis, and further, measurement of TNF-alpha (显示 TNF ELISA试剂盒) and sCD163 can identify the most severe cases of tuberculosis.
The macrophage activation marker CD163 was increased in patients with active pulmonary TB compared with age- and sex-matched control subjects.
alveolar macrophages from asthmatic subjects have reduced cell-surface expression of CD163, which suggests that CD163 might modulate the pathogenesis of asthma
Serum sCD163 might be a potential biomarker for predicting the severity and prognosis of PM/DM-related interstitial lung disease
Soluble CD163 reflecting macrophage activation is associated with morphological features of non-alcoholic fatty liver disease. An independent association between sCD163 and cytokeratin-18 (显示 KRT18 ELISA试剂盒) suggests that apoptosis may contribute to macrophage activation in NAFLD (显示 TSC2 ELISA试剂盒)/NASH (显示 SAMSN1 ELISA试剂盒).
Most cases of histiocytic sarcoma expressed histiocytic markers CD68 (显示 CD68 ELISA试剂盒) (6 of 7 cases), CD163 (5 of 5 cases), and PU.1 (3 of 4 cases).
Within a diabetic cohort, the percentage of monocytes expressing CD163 was decreased in those subjects with complications, compared to those without complications. These changes were not accompanied by a change in gene expression. Glucocorticoids increased CD163 expression in cultured peripheral blood monocytes from non-diabetic persons.
deletion of Exon 7 of the CD163 gene, encoding SRCR5 had no adverse effects in pigs and these animals showed complete resistance to viral infection by the positive-strand RNA PRRS virus
CD163 is not necessary for infection with African swine fever virus.
CD163 represents an additional candidate gene for resistance against porcine reproductive and respiratory syndrome.
Overexpression of ADAM17 (显示 ADAM17 ELISA试剂盒) induced downregulation of CD163 expression and a reduction in reproductive and respiratory syndrome virus infection.
Fusion protein of sialoadhesin (显示 SIGLEC1 ELISA试剂盒) and domains 5-9 of CD163 receptors blocked the respiratory syndrome virus infection.
GP4 (显示 CD36 ELISA试剂盒) is involved in interaction with cellular receptor CD163.
). These results provided fundamental evidence for CD163 and SN as two functional candidate genes affecting immunity in pigs.
Porcine reproductive and respiratory syndrome virus GP4 (显示 CD36 ELISA试剂盒) was found to co-localize with CD163 in the lipid rafts on the plasma membrane.
Our results suggest that the intracellular domain of CD163 may be associated with an important yet-unknown function during porcine reproductive and respiratory syndrome virus replication.
The newly established porcine alveolar macrophage cell lines were demonstrated to express robust levels of CD163 and to be fully permissive for both type 1 and 2 porcine reproductive and respiratory syndrome virus strains.
The protein encoded by this gene is a member of the scavenger receptor cysteine-rich (SRCR) superfamily, and is exclusively expressed in monocytes and macrophages. It functions as an acute phase-regulated receptor involved in the clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages, and may thereby protect tissues from free hemoglobin-mediated oxidative damage. This protein may also function as an innate immune sensor for bacteria and inducer of local inflammation. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
, CD163 molecule
, scavenger receptor cysteine-rich type 1 protein M130-like
, scavenger receptor cysteine-rich type 1 protein M130
, hemoglobin scavenger receptor
, macrophage-associated antigen