Budding Uninhibited By Benzimidazoles 1 Homolog beta (Yeast) (BUB1B) ELISA试剂盒

BUB1B encodes a kinase involved in spindle checkpoint function. 再加上,我们可以发BUB1B 抗体 (179)BUB1B 蛋白 (8)和数多这个蛋白质的别的产品。

list all ELISA KIts 基因 基因ID UniProt
 BUB1B BUB1B 701 O60566
大鼠 BUB1B BUB1B 171576  
BUB1B 12236 Q9Z1S0

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小鼠 9.38 pg/mL 37.5-2400 pg/mL Typical standard curve 96 Tests Log in to see 9至12个工作日
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适于 BUB1B 相互作用对的更多 ELISA 试剂盒

Xenopus laevis Budding Uninhibited By Benzimidazoles 1 Homolog beta (Yeast) (BUB1B) interaction partners

  1. Together, our findings demonstrate that Bub1 (显示 BUB1 ELISA试剂盒) acts at multiple points to assure the correct kinetochore formation.

Fruit Fly (Drosophila melanogaster) Budding Uninhibited By Benzimidazoles 1 Homolog beta (Yeast) (BUB1B) interaction partners

  1. The Bub3 (显示 BUB3 ELISA试剂盒)-BubR1 complex on broken DNA inhibits the APC (显示 APC ELISA试剂盒)/C locally via the sequestration of Cdc20 (显示 CDC20 ELISA试剂盒).

  2. a model in which Polo (显示 PLK1 ELISA试剂盒) controls Mps1-dependent BubR1 phosphorylation to promote Cdc20 (显示 CDC20 ELISA试剂盒) kinetochore recruitment and sustained SAC (显示 ADCY10 ELISA试剂盒) function.

  3. Data show that the Mad2 (显示 MAD2L1 ELISA试剂盒) kinetochore dimerization recruitment mechanism is conserved and that the recruitment of Cdc20 (显示 CDC20 ELISA试剂盒) to kinetochores in Drosophila requires BubR1 but not Mad2 (显示 MAD2L1 ELISA试剂盒).

  4. Reduced BubR1 or Polo (显示 PLK1 ELISA试剂盒) function results in abnormal segregation of acentric chromatids, a decrease in acentric chromosome tethering, and a great reduction in adult survival.

  5. BubR1's role in mitosis is discussed.

  6. BubR1 is required for normal synchrony and progression of syncytial nuclei through mitosis and to maintain the mitotic arrest of the polar body chromosomes after completion of meiosis

  7. BubR1 is required to promote stable microtubule kinetochore attachment. Activation of the mechanism that corrects inappropriate kinetochore attachment requires the antagonistic effects of BubR1 and CENP-E (显示 CENPE ELISA试剂盒).

  8. Recruitment of BubR1 by dysfunctional telomeres inhibits Cdc20 (显示 CDC20 ELISA试剂盒)-APC (显示 APC ELISA试剂盒) function, preventing the metaphase-to-anaphase transition.

Human Budding Uninhibited By Benzimidazoles 1 Homolog beta (Yeast) (BUB1B) interaction partners

  1. Whether carriers of pathogenic BUB1B mutations, such as the parents of MVA (显示 MYO5A ELISA试剂盒) syndrome patients, have an increased risk for cancer remains of interest, as studies in mice have suggested that haploinsufficiency of BUB1B may cause an increase in carcinogen-induced tumors

  2. structure of the PP2A B56-BubR1 complex provides important insights into how the B56 subunit directs the recruitment of PP2A to specific targets.

  3. Overexpression of BUB1B is associated with Invasive Breast Cancer.

  4. we showed that BubR1 and Mad2 (显示 MAD2L1 ELISA试剂盒) are overexpressed in oral squamous cell carcinoma cell lines and linked such overexpression to attenuated spindle assembly checkpoint activity. We also showed BubR1 overexpression to be associated with advanced stage and tumour size.

  5. The integrity of the mitotic checkpoint (显示 BUB3 ELISA试剂盒) complex depends on the specific recognition between BubR1 and Bub3 (显示 BUB3 ELISA试剂盒), for which the BubR1 Gle2 (显示 RAE1 ELISA试剂盒) binding sequence motif is essential.

  6. We show that kinetochore recruitment of BUBR1 and BUB3 (显示 BUB3 ELISA试剂盒) by BUB1 (显示 BUB1 ELISA试剂盒) is dispensable for SAC (显示 ADCY10 ELISA试剂盒) activation

  7. Data suggest that both BubR1 and SNCG may be promising predictive marker rather than prognostic marker in patients with breast cancer.

  8. BubR1 knockdown significantly decreased cellular invasion but slightly affect cellular proliferation on both Ca9 (显示 CA9 ELISA试剂盒)-22 and Cal (显示 FBLIM1 ELISA试剂盒)-27 cells.

  9. BubR1 contributes to preventing premature aging. [review]

  10. Suggest human papillomavirus E2 protein (显示 UBE2B ELISA试剂盒) provokes BUBR1-dependent aneuploidy in HPV-induced cervical cancer.

Mouse (Murine) Budding Uninhibited By Benzimidazoles 1 Homolog beta (Yeast) (BUB1B) interaction partners

  1. EZH2 (显示 EZH2 ELISA试剂盒) directly interacted with and stabilized BubR1, an effect driving EZH2 (显示 EZH2 ELISA试剂盒) into the concert of meiosis regulation.

  2. we quantified the frequency of aneuploidy of three autosomes in the cerebral cortex and cerebellum of adult and developing brain of Bub1b(H/H) mice, which have a faulty mitotic checkpoint (显示 BUB3 ELISA试剂盒), and Ercc1 (显示 ERCC1 ELISA试剂盒)(-/Delta7) mice, defective in nucleotide excision repair and inter-strand cross-link repair.we found that Bub1b(H/H), but not Ercc1 (显示 ERCC1 ELISA试剂盒)(-/Delta7) mice, have a significantly higher frequency of aneuploid nuclei relative to wild-t...

  3. Data show that compound mutant spindle assembly checkpoint components BubR1 and Sgo1 (显示 SGOL1 ELISA试剂盒) embryonic fibroblasts (MEFs) grew at a much slower rate, and a small fraction of cells exhibited morphologies of senescent cells at early passages.

  4. These data reveal that BubR1 plays a multifaceted role in chromosome segregation during the first meiotic division and suggest that age-related decline of BubR1 is a key determinant of the formation of aneuploid oocytes during aging.

  5. BubR1 (-/-) embryos were aneuploid and had an increased level of premature sister chromatid separation.

  6. Low BubR1 expression almost completely inhibited intimal hyperplasia after carotid ligation by suppressing the proliferation of VSMCs, which was caused, in part, by delayed cell cycle progression.

  7. the loss of BubR1 levels with age is due to a decline in NAD(+) and the ability of SIRT2 (显示 SIRT2 ELISA试剂盒) to maintain lysine-668 of BubR1 in a deacetylated state, which is counteracted by the acetyltransferase CBP (显示 CREBBP ELISA试剂盒).

  8. BubR1 insufficiency elicits an aging response that is counteracted by p53 (显示 TP53 ELISA试剂盒) and involves single or multiple p53 (显示 TP53 ELISA试剂盒) targets, depending on the tissue type.

  9. BubR1 acetylation is essential for embryonic development.

  10. these data demonstrate that the BUBR1 GTTA mutation compromises longevity and healthspan, raising the interesting possibility that mono-allelic changes in BUBR1 might contribute to differences in aging rates in the general population.

BUB1B 抗原简介

Antigen Summary

This gene encodes a kinase involved in spindle checkpoint function. The protein has been localized to the kinetochore and plays a role in the inhibition of the anaphase-promoting complex/cyclosome (APC/C), delaying the onset of anaphase and ensuring proper chromosome segregation. Impaired spindle checkpoint function has been found in many forms of cancer.

Gene names and symbols associated with BUB1B

  • BUB1 mitotic checkpoint serine/threonine kinase B (bub1b) 抗体
  • budding uninhibited by benzimidazoles 1 homolog beta (yeast) (BUB1B) 抗体
  • Mitotic checkpoint serine/threonine-protein kinase BUB1 beta (bub1b) 抗体
  • Bub1 homologue (Bub1) 抗体
  • Bub1-related kinase (BubR1) 抗体
  • BUB1 mitotic checkpoint serine/threonine kinase B (BUB1B) 抗体
  • BUB1 mitotic checkpoint serine/threonine kinase B (Bub1b) 抗体
  • budding uninhibited by benzimidazoles 1 homolog, beta (S. cerevisiae) (Bub1b) 抗体
  • 31/13 抗体
  • AU045529 抗体
  • BcDNA:LD23835 抗体
  • Bub1 抗体
  • BUB1-like 抗体
  • Bub1A 抗体
  • bub1b 抗体
  • BUB1beta 抗体
  • bubr1 抗体
  • BubRI 抗体
  • CG7838 抗体
  • CG 7838 抗体
  • CG14030 抗体
  • CG14030/Bub1 抗体
  • dBUB1 抗体
  • Dmbub1 抗体
  • Dmel\\CG7838 抗体
  • Dmel\\CG14030 抗体
  • hBUBR1 抗体
  • l(2)k03113 抗体
  • l(2)k06109 抗体
  • MAD3L 抗体
  • mcl(2)Z1525 抗体
  • MVA1 抗体
  • SSK1 抗体

Protein level used designations for BUB1B

BUB1 budding uninhibited by benzimidazoles 1 homolog beta , budding uninhibited by benzimidazoles 1 beta , budding uninhibited by benzimidazoles 1 homolog beta , mitotic checkpoint serine/threonine-protein kinase BUB1 beta , budding uninhibited by benzimidazoles 1 homolog beta (yeast) , mitotic checkpoint serine/threonine-protein kinase BUB1 beta-like , Bub1-PA , CG14030-PA , Bub1 , BubR1-PA , CG7838-PA , bub related one , mcl(2)Z1525 , MAD3/BUB1-related protein kinase , mitotic checkpoint kinase MAD3L , budding uninhibited by benzimidazoles 1 homolog, beta

GENE ID SPECIES
378923 Xenopus laevis
453324 Pan troglodytes
537027 Bos taurus
100125106 Xenopus (Silurana) tropicalis
100196482 Salmo salar
100413586 Callithrix jacchus
100423079 Macaca mulatta
100455824 Pongo abelii
100464546 Ailuropoda melanoleuca
100607252 Nomascus leucogenys
100629735 Equus caballus
33758 Drosophila melanogaster
35522 Drosophila melanogaster
378922 Gallus gallus
701 Homo sapiens
171576 Rattus norvegicus
608350 Canis lupus familiaris
12236 Mus musculus
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