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BUB1 encodes a kinase involved in spindle checkpoint function. 再加上，我们可以发BUB1 抗体 (141) 和 BUB1 蛋白 (6)和数多这个蛋白质的别的产品。
Chromosomal rearrangement resulting in BUB1 haploinsufficiency identified in a patient with polycystic liver disease. BUB1 may imply germline causes of genetic instability in PLD (显示 PLD ELISA试剂盒).
Results report that BubR1 (显示 BUB1B ELISA试剂盒) and RepoMan bind directly to PP2A (显示 PPP2R4 ELISA试剂盒)-B56 using an LSPIxE short linear motif (SLiM), where phosphorylation of the Ser (显示 SIGLEC1 ELISA试剂盒) residue enhances binding. RepoMan and BubR1 (显示 BUB1B ELISA试剂盒) bind B56 using both hydrophobic and electrostatic interactions.
Inhibition of Bub1 kinase impaired chromosome arm resolution but exerted only minor effects on mitotic progression or spindle assembly checkpoint function.
Study shows that BUB1beta (显示 BUB1B ELISA试剂盒) and PDZ binding kinase (显示 PBK ELISA试剂盒) are up-regulated in breast cancer tumors and their expression is associated with improved overall survival (OS) in basal-like tumors but worse OS in luminal and untreated patients.
Bub1 may be associated with cancer stem cell potential.
Both Bub1 and BubR1 (显示 BUB1B ELISA试剂盒) bind stably to Bub3 (显示 BUB3 ELISA试剂盒) that is required for kinetochore localization of the proteins
Bub1-Plk1 (显示 PLK1 ELISA试剂盒)-mediated phosphorylation of Cdc20 (显示 CDC20 ELISA试剂盒) constitutes an anaphase-promoting complex or cyclosome-inhibitory mechanism that is parallel, but not redundant, to mitotic checkpoint (显示 BUB3 ELISA试剂盒) complex formation.
Data show that mitotic checkpoint (显示 BUB3 ELISA试剂盒) kinase (显示 ATR ELISA试剂盒) Bub1 is an active kinase regulated by intra-molecular phosphorylation at the P+1 loop.
human BUB1 does not associate stably with the MAD2 (显示 MAD2L1 ELISA试剂盒) activator MAD1 (显示 MXD1 ELISA试剂盒) (also known as MAD1L1 (显示 MAD1L1 ELISA试剂盒)) and, although required for accelerating the loading of MAD1 (显示 MXD1 ELISA试剂盒) onto kinetochores, BUB1 is dispensable for the maintenance of steady-state levels of MAD1 (显示 MXD1 ELISA试剂盒) there
MAD2L1 (显示 MAD2L1 ELISA试剂盒) and BUB1 may play important roles in breast cancer progression, and measuring the expression of these genes may assist the prediction of breast cancer prognosis.
Bub1 coordinates checkpoint signalling by distinct domains for RZZ and BubR1 (显示 BUB1B ELISA试剂盒) recruitment and localizes antagonistic checkpoint activities.
It was shown that that Bub1 kinase activity integrates attachment error correction and mitotic checkpoint signaling by controlling the localization and activity of Aurora B kinase through phosphorylation of histone H2A at threonine 121.
Results establish that Bub1 has oncogenic properties and suggest that Aurora B (显示 AURKC ELISA试剂盒) is a critical target through which overexpressed Bub1 drives aneuploidization and tumorigenesis.
It seems that Sgo1 (显示 SGOL1 ELISA试剂盒) sets up the centromeric protection mechanism in G2, but that its Bub1-dependent localisation to centromeres during mitosis is not required to maintain cohesion.
mutations of Bub1 and BubR1 (显示 BUB1B ELISA试剂盒) found in Brca2 (显示 BRCA2 ELISA试剂盒)- mutant mice indeed are responsible for the chromosome instability in Brca2 (显示 BRCA2 ELISA试剂盒)-mutated tumors
Our data suggest that Bub1 is a critical spindle checkpoint protein that regulates accurate chromosome alignment and homolog disjunction in mammalian oocyte meiosis.
Bub1 is important for mediating cell death when chromosomes missegregate.
Bub1 is essential for proper chromosome segregation, a defect that can lead to severe phenotypes, including perinatal lethality and a predisposition to cancer.
Data show that the anaphase-promoting complex is activated in an exponential fashion after germinal vesicle breakdown in oocytes and that this process is advanced by 5 hr in oocytes lacking Bub1.
Bub1 dysfunction is linked to inherited aneuploidy in female germ cells and may contribute to the maternal age-related increase in aneuploidy and pregnancy loss.
This gene encodes a kinase involved in spindle checkpoint function. The kinase functions in part by phosphorylating a member of the miotic checkpoint complex and activating the spindle checkpoint. Mutations in this gene have been associated with aneuploidy and several forms of cancer.
BUB1 budding uninhibited by benzimidazoles 1 homolog
, mitotic checkpoint serine/threonine-protein kinase BUB1
, budding uninhibited by benzimidazoles 1
, budding uninhibited by benzimidazoles 1 homolog
, mitotic spindle checkpoint kinase
, putative serine/threonine-protein kinase