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BCAT1 encodes the cytosolic form of the enzyme branched-chain amino acid transaminase. 再加上，我们可以发BCAT1 抗体 (96) 和 BCAT1 蛋白 (12)和数多这个蛋白质的别的产品。
BCAT1 plays a pathogenic role in hepatocellular carcinoma (HCC (显示 FAM126A ELISA试剂盒)) by causing cell proliferation and chemoresistance. The MYC (显示 MYC ELISA试剂盒) transcription factor is involved in regulating the transcriptional activity of BCAT1. BCAT1 expression has prognostic significance for the survival of patients with HCC (显示 FAM126A ELISA试剂盒).
Phenotypic analyses using a lentiviral-mediated BCAT1 short hairpin RNA knockdown revealed that BCAT1 sustains proliferation in addition to migration and invasion and that its overexpression enhanced the capacity of antiestrogen-sensitive cells to grow in the presence of antiestrogens.
The tumor suppressive role of miR-218 was mediated by negatively regulating branched-chain amino acid transaminase 1 (BCAT1) protein expression. Importantly, overexpression of BCAT1 decreased the chemosensitivity to cis-diaminedichloroplatinum treatment of PC3 and DU145 cells.
It has been demonstrated that branched-chain amino acid (BCAA (显示 ARID4B ELISA试剂盒)) catabolism is activated in human breast cancer, and abolishment of BCAA (显示 ARID4B ELISA试剂盒) catabolism by knocking down BCAT1 inhibits breast cancer cell growth by repressing mTOR (显示 FRAP1 ELISA试剂盒)-mediated mitochondrial biogenesis and function.
BCAT1 expression is significantly upregulated in human masticatory mucosa during wound healing
Mechanistic investigation revealed that BCAT1 might be an important regulator responsible for DOT1L (显示 DOT1L ELISA试剂盒)-mediated sphere formation and cell migration in breast cancer cells
BCAT1 overexpression is associated with advanced tumour status, and implies adverse clinical outcomes of urothelial carcinoma
BCAT1 is strongly overexpressed in ovarian cancer.
Focal deletions of the BCAT1 were associated with B-cell precursor acute lymphoblastic leukemia.
levels of branched-chain aminotransferase-1 (BCAT1) transcripts are significantly decreased on the polysomes of both RPS19 (显示 RPS19 ELISA试剂盒) and RPL11 (显示 RPL11 ELISA试剂盒) cells and that translation of BCAT1 protein is especially impaired in cells with small RP gene mutations
results suggest transcriptional adaptations occur in BCATm (显示 BCAT2 ELISA试剂盒) KO mice that along with altered nutrient signaling may contribute to their previously reported protein turnover, metabolic and exercise phenotypes
BCATc as a novel regulator of T cell activation and metabolism
leucine supplementation increased the expression of enzymes (BCAT1, BCAT2 (显示 BCAT2 ELISA试剂盒) and BCKDK (显示 BCKDK ELISA试剂盒)) that metabolize branched-chain amino acids.
analysis of the biochemical mechanism of BCATm (显示 BCAT2 ELISA试剂盒) (branched-chain aminotransferase) catalysis of reversible transamination of leucine and alpha-ketoglutarate to KIC and glutamate (显示 GRIN1 ELISA试剂盒)
Bcat1 is a candidate for the type I diabetes susceptibility locus Idd6
Bcat1 is part of the complex multigenic Pas1 locus, with a functional role for its intragenic polymorphisms in lung tumor susceptibility.
These results demonstrate that the expression of the BCATc gene in the brain is specifically regulated by BDNF (显示 BDNF ELISA试剂盒) in a time- and region-dependent fashion.
BCATc mRNA gradually appears in different brain regions starting from early stages of neural development, and is maintained until adulthood.
BCATm (显示 BCAT2 ELISA试剂盒)(-/-) mice had elevated plasma branched-chain amino acids & decreased adiposity & body weight, despite eating more food, along with increased energy expenditure, improvements in glucose & insulin (显示 INS ELISA试剂盒) tolerance & protection from diet-induced obesity
This gene encodes the cytosolic form of the enzyme branched-chain amino acid transaminase. This enzyme catalyzes the reversible transamination of branched-chain alpha-keto acids to branched-chain L-amino acids essential for cell growth. Two different clinical disorders have been attributed to a defect of branched-chain amino acid transamination: hypervalinemia and hyperleucine-isoleucinemia. As there is also a gene encoding a mitochondrial form of this enzyme, mutations in either gene may contribute to these disorders. Alternatively spliced transcript variants have been described.
branched-chain-amino-acid aminotransferase, cytosolic
, branched chain aminotransferase 1, cytosolic
, branched chain amino-acid transaminase 1, cytosolic
, branched-chain-amino-acid aminotransferase, cytosolic-like
, placental protein 18
, cytosolic branched-chain amino acid aminotransferase