anti-BR serine/threonine Kinase 2 (BRSK2) 抗体

Serine/threonine-protein kinase that plays a key role in polarization of neurons. 再加上,我们可以发BR serine/threonine Kinase 2 蛋白 (7)BR serine/threonine Kinase 2 试剂盒 (3)和数多这个蛋白质的别的产品。

列出全部抗体 基因 基因ID UniProt
BRSK2 9024 Q8IWQ3
BRSK2 75770 Q69Z98
BRSK2 293631  

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产品编号 适用 宿主 标记 应用范围 图像 规格 供应商 交付 价格 详细
非结合性 IHC (p), WB Western blot analysis of anti-STK29 Pab(ABIN391285) in HL60 cell line lysate (35 µg/lane). STK29(arrow) was detected using the purified polyclonal antibody (1:60 dilution). Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. BC = breast carcinoma. HC = hepatocarcinoma 400 μL Log in to see 5至8个工作日
¥2,325.14
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山羊 非结合性 ELISA, WB   100 μg Log in to see 24至29个工作日
¥6,589.10
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小鼠 非结合性 WB Mouse Brsk2 Antibody (Center)  western blot analysis in mouse testis tissue lysates (35ug/lane).This demonstrates the Brsk2 antibody detected the Brsk2 protein (arrow). 400 μL Log in to see 5至8个工作日
¥2,325.14
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非结合性 EIA, IHC (p), WB   0.1 mg Log in to see 30至37个工作日
¥3,065.96
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非结合性 IHC, ELISA, WB   100 μg Log in to see 33至41个工作日
¥4,502.45
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非结合性 ELISA, IF, IHC, IHC (p), WB Immunohistochemistry: BRSK2 Antibody [NBP1-77281] - BRSK2 in human brain tissue with BRSK2 antibody at 5 ug/mL. Immunofluorescence: BRSK2 Antibody [NBP1-77281] - BRSK2 in Human Brain cells with BRSK2 antibody at 20 ug/mL. 0.1 mg Log in to see 26至33个工作日
¥3,655.56
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小鸡 山羊 非结合性 ELISA   100 μg Log in to see 29至35个工作日
¥4,303.48
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非结合性 IP, WB   100 μL Log in to see 29至35个工作日
¥6,774.38
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非结合性 IHC, WB   100 μg Log in to see 29至35个工作日
¥5,401.63
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PE IHC, ELISA, WB   200 μL Log in to see 29至35个工作日
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通过反应活性、应用领域、克隆类型和共轭标记 BRSK2 抗体

特性 应用范围 宿主 克隆类型 标记
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引用最多的anti-BR serine/threonine Kinase 2 抗体

  1. Human Polyclonal BRSK2 Primary Antibody for IHC, ELISA - ABIN1001943 : Lizcano, Göransson, Toth, Deak, Morrice, Boudeau, Hawley, Udd, Mäkelä, Hardie, Alessi: LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1. in The EMBO journal 2004 (PubMed)
    Show all 4 references for 1001943

  2. Human Polyclonal BRSK2 Primary Antibody for ELISA, WB - ABIN185503 : Kishi, Pan, Crump, Sanes: Mammalian SAD kinases are required for neuronal polarization. in Science (New York, N.Y.) 2005 (PubMed)

更多抗BR serine/threonine Kinase 2的相互作用对抗体

Human BR serine/threonine Kinase 2 (BRSK2) interaction partners

  1. SAD-A and AMPK (显示 PRKAA1 抗体) kinases are regulators of mTORC1 signaling in the pancreatic beta-cells.

  2. BRSK2 interacted with VCP/p97 (显示 vcp 抗体) via three of the four functional domains of VCP/p97 (显示 vcp 抗体). Immunofluorescence demonstrated that BRSK2 and VCP/p97 (显示 vcp 抗体) were co-localized and also that knockdown of endogenous BRSK2 induced increased levels of CD3delta (显示 CD3D 抗体).

  3. Anaphase-promoting complex/cyclosome-Cdh1 (显示 CDH1 抗体), rather than Cdc20 (显示 CDC20 抗体), promotes the degradation of BRSK2 in vivo.

  4. a novel function of BRSK2 in the regulation of GSIS in beta-cells via a PCTAIRE1 (显示 CDK16 抗体)-dependent mechanism and suggest that BRSK2 is an attractive target for developing novel diabetic drugs.

  5. these findings demonstrate ER stress may reduce BRSK2 protein and change BRSK2 subcellular localization, which in turn alleviate ER stress-induced apoptosis.

  6. these findings provide a novel regulatory mechanism of BRSK2 through direct interaction with Jab1 (显示 COPS5 抗体).

  7. BRSK2 is up-regulated in pancreatic ductal adenocarcinoma.

  8. BRSK2 may be an autoantigen involved in the pathogenesis of small-cell lung cancer-associated limbic encephalitis.

  9. we identified cAMP-dependent protein kinase A (PKA) as another upstream kinase of BRSK2, which can phosphorylate BRSK2 at Thr260. Kinase activity of BRSK2 can be increased through phosphorylation by PKA.

  10. protein phosphatase 2C (显示 PDP 抗体) is a likely candidate for catalyzing the dephosphorylation and inactivation of BRSK1 (显示 BRSK1 抗体)/2.

Mouse (Murine) BR serine/threonine Kinase 2 (BRSK2) interaction partners

  1. SAD-A and AMPK (显示 PRKAA1 抗体) kinases are regulators of mTORC1 signaling in the pancreatic beta-cells.

  2. SAD-A and SAD-B (显示 BRSK1 抗体) kinases have multiple, sequential roles in axonal differentiation

  3. SAD-A kinase controls islet beta-cell size and function as a mediator of mTORC1 signaling.

  4. SAD-A kinase is a pancreas-specific mediator of incretin response in islet beta cells.

  5. a novel function of BRSK2 in the regulation of GSIS in beta-cells via a PCTAIRE1 (显示 CDK16 抗体)-dependent mechanism and suggest that BRSK2 is an attractive target for developing novel diabetic drugs.

  6. a critical role of SAD-A in the activation of PAK1 (显示 PAK1 抗体) during the onset of insulin (显示 INS 抗体) exocytosis.

  7. The regulation of Wee1 (显示 WEE1 抗体) by SadA and SadB (显示 BRSK1 抗体) kinases is essential for the differentiation of polarized neurons.

  8. results show that SAD-A and SAD-B (显示 BRSK1 抗体), mammalian orthologs of a kinase needed for presynaptic differentiation in Caenorhabditis elegans, are required for neuronal polarization.

  9. Once activated, LKB1 (显示 STK11 抗体) phosphorylates and thereby activates SAD-A and SAD-B (显示 BRSK1 抗体) kinases, which are also required for neuronal polarization in the cerebral cortex.

BR serine/threonine Kinase 2 (BRSK2) 抗原简介

蛋白简介

Serine/threonine-protein kinase that plays a key role in polarization of neurons. Phosphorylates MAPT/TAU and WEE1. Following phosphorylation and activation by STK11/LKB1, acts as a key regulator of polarization of cortical neurons, probably by mediating phosphorylation of microtubule-associated proteins such as MAPT/TAU at 'Ser-554'. Also regulates neuron polarization by mediating phosphorylation of WEE1 at 'Ser-642' in post-mitotic neurons, leading to down-regulate WEE1 activity in polarized neurons.

Gene names and symbols associated with BRSK2

  • BR serine/threonine kinase 2 (BRSK2) 抗体
  • BR serine/threonine kinase 2 (Brsk2) 抗体
  • 4833424K13Rik 抗体
  • BRSK2 抗体
  • C11orf7 抗体
  • PEN11B 抗体
  • SAD-A 抗体
  • SAD1 抗体
  • SADA 抗体
  • STK29 抗体

Protein level used designations for BRSK2

BR serine/threonine-protein kinase 2 , BR serine/threonine kinase 2 , BR serine/threonine-protein kinase 2-like , brain-selective kinase 2 , brain-specific serine/threonine-protein kinase 2 , protein kinase SAD1B , serine/threonine-protein kinase 29 , serine/threonine-protein kinase BRSK2 , serine/threonine-protein kinase SAD-A , brain serine/threonine kinase 2

GENE ID SPECIES
423098 Gallus gallus
535868 Bos taurus
744454 Pan troglodytes
746226 Pan troglodytes
100395256 Callithrix jacchus
100429659 Macaca mulatta
100443903 Pongo abelii
9024 Homo sapiens
75770 Mus musculus
483658 Canis lupus familiaris
293631 Rattus norvegicus
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