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Serine/threonine-protein kinase that plays a key role in polarization of neurons. 再加上，我们可以发BR serine/threonine Kinase 2 蛋白 (8) 和 BR serine/threonine Kinase 2 试剂盒 (3)和数多这个蛋白质的别的产品。
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Human Polyclonal BRSK2 Primary Antibody for IHC, ELISA - ABIN1001943
Lizcano, Göransson, Toth, Deak, Morrice, Boudeau, Hawley, Udd, Mäkelä, Hardie, Alessi: LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1. in The EMBO journal 2004
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SAD-A and AMPK (显示 PRKAA1 抗体) kinases are regulators of mTORC1 signaling in the pancreatic beta-cells.
BRSK2 interacted with VCP/p97 (显示 vcp 抗体) via three of the four functional domains of VCP/p97 (显示 vcp 抗体). Immunofluorescence demonstrated that BRSK2 and VCP/p97 (显示 vcp 抗体) were co-localized and also that knockdown of endogenous BRSK2 induced increased levels of CD3delta (显示 CD3D 抗体).
Anaphase-promoting complex/cyclosome-Cdh1 (显示 CDH1 抗体), rather than Cdc20 (显示 CDC20 抗体), promotes the degradation of BRSK2 in vivo.
a novel function of BRSK2 in the regulation of GSIS in beta-cells via a PCTAIRE1 (显示 CDK16 抗体)-dependent mechanism and suggest that BRSK2 is an attractive target for developing novel diabetic drugs.
these findings demonstrate ER stress may reduce BRSK2 protein and change BRSK2 subcellular localization, which in turn alleviate ER stress-induced apoptosis.
these findings provide a novel regulatory mechanism of BRSK2 through direct interaction with Jab1 (显示 COPS5 抗体).
BRSK2 is up-regulated in pancreatic ductal adenocarcinoma.
BRSK2 may be an autoantigen involved in the pathogenesis of small-cell lung cancer-associated limbic encephalitis.
we identified cAMP-dependent protein kinase A (PKA) as another upstream kinase of BRSK2, which can phosphorylate BRSK2 at Thr260. Kinase activity of BRSK2 can be increased through phosphorylation by PKA.
protein phosphatase 2C (显示 PDP 抗体) is a likely candidate for catalyzing the dephosphorylation and inactivation of BRSK1 (显示 BRSK1 抗体)/2.
SAD-A and SAD-B (显示 BRSK1 抗体) kinases have multiple, sequential roles in axonal differentiation
SAD-A kinase controls islet beta-cell size and function as a mediator of mTORC1 signaling.
SAD-A kinase is a pancreas-specific mediator of incretin response in islet beta cells.
a critical role of SAD-A in the activation of PAK1 (显示 PAK1 抗体) during the onset of insulin (显示 INS 抗体) exocytosis.
The regulation of Wee1 (显示 WEE1 抗体) by SadA and SadB (显示 BRSK1 抗体) kinases is essential for the differentiation of polarized neurons.
results show that SAD-A and SAD-B (显示 BRSK1 抗体), mammalian orthologs of a kinase needed for presynaptic differentiation in Caenorhabditis elegans, are required for neuronal polarization.
Once activated, LKB1 (显示 STK11 抗体) phosphorylates and thereby activates SAD-A and SAD-B (显示 BRSK1 抗体) kinases, which are also required for neuronal polarization in the cerebral cortex.
Serine/threonine-protein kinase that plays a key role in polarization of neurons. Phosphorylates MAPT/TAU and WEE1. Following phosphorylation and activation by STK11/LKB1, acts as a key regulator of polarization of cortical neurons, probably by mediating phosphorylation of microtubule-associated proteins such as MAPT/TAU at 'Ser-554'. Also regulates neuron polarization by mediating phosphorylation of WEE1 at 'Ser-642' in post-mitotic neurons, leading to down-regulate WEE1 activity in polarized neurons.
BR serine/threonine-protein kinase 2
, BR serine/threonine kinase 2
, BR serine/threonine-protein kinase 2-like
, brain-selective kinase 2
, brain-specific serine/threonine-protein kinase 2
, protein kinase SAD1B
, serine/threonine-protein kinase 29
, serine/threonine-protein kinase BRSK2
, serine/threonine-protein kinase SAD-A
, brain serine/threonine kinase 2