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BRSK1 蛋白

(BR Serine/threonine Kinase 1 (BRSK1))
Serine/threonine-protein kinase that plays a key role in polarization of neurons and centrosome duplication. Phosphorylates CDC25B, CDC25C, MAPT/TAU, RIMS1, TUBG1, TUBG2 and WEE1. Following phosphorylation and activation by STK11/LKB1, acts as a key regulator of polarization of cortical neurons, probably by mediating phosphorylation of microtubule-associated proteins such as MAPT/TAU at 'Ser-573'. Also regulates neuron polarization by mediating phosphorylation of WEE1 at 'Ser-642' in post-mitotic neurons, leading to down-regulate WEE1 activity in polarized neurons. Also acts as a positive regulator of centrosome duplication by mediating phosphorylation of gamma-tubulin (TUBG1 and TUBG2) at 'Ser-131', leading to translocation of gamma-tubulin and its associated proteins to the centrosome. Involved in the UV- induced DNA damage checkpoint response, probably by inhibiting CDK1 activity through phosphorylation and activation of WEE1, and inhibition of CDC25B and CDC25C (By similarity). In neurons, localizes to synaptic vesicles and plays a role in neurotransmitter release, possibly by phosphorylating RIMS1.
BRSK1 Protein (AA 1-778) (GST tag) BRSK1 Protein (AA 1-778) (GST tag) BRSK1 Protein (AA 1-778) (GST tag) (ABIN5570636)

BRSK1 宿主: 人 宿主: Insect cells (Sf21) Recombinant SDS, Func Active

BRSK1 Protein (AA 289-380) (GST tag) BRSK1 Protein (AA 289-380) (GST tag) BRSK1 Protein (AA 289-380) (GST tag) (ABIN1346887)

BRSK1 宿主: 人 宿主: 小麦胚 Recombinant ELISA, WB, AA, AP

BRSK1 Protein (AA 1-778) (His tag) BRSK1 Protein (AA 1-778) (His tag) BRSK1 Protein (AA 1-778) (His tag) (ABIN3090446)

Crystallography grade BRSK1 宿主: 人 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. ELISA, WB, SDS, Crys

BRSK1 蛋白 by Grade

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BRSK1 蛋白 by Origin

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BRSK1 蛋白 by Source

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BRSK1 蛋白 by 蛋白类型

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Popular BRSK1 蛋白

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Insect cells (Sf21)
Validations
  • (2)
Cat. No. ABIN5570636
Quantity 5 μg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1346887
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Insect Cells
Validations
  • (1)
Cat. No. ABIN3090446
Quantity 1 mg
Datasheet Datasheet
Reactivity Mouse
Source Insect Cells
Validations
  • (1)
Cat. No. ABIN3135216
Quantity 1 mg
Datasheet Datasheet
Reactivity Mouse
Source Insect Cells
Validations
Cat. No. ABIN5509205
Quantity 10 μg
Datasheet Datasheet
Reactivity Rat
Source Yeast
Validations
Cat. No. ABIN1670475
Quantity 1 mg
Datasheet Datasheet

Aliases for BRSK1 蛋白

BR serine/threonine kinase 1 (BRSK1) 蛋白
BR serine/threonine kinase 1 (Brsk1) 蛋白
BRSK1 蛋白
Gm1100 蛋白
hSAD1 蛋白
RGD1563268 蛋白
SAD-B 蛋白
Sad-b 蛋白
SADB 蛋白
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