Use your antibodies-online credentials, if available.
ASPN encodes a cartilage extracellular protein that is member of the small leucine-rich proteoglycan family. 再加上，我们可以发Asporin 抗体 (49) 和 Asporin 蛋白 (5)和数多这个蛋白质的别的产品。
Showing 10 out of 39 products:
ASPN D15 (显示 MRPL16 ELISA试剂盒) is associated with increased risk of symmetrical hand osteoarthritis particularly in individuals with low variation in work tasks.
we found that asporin can be downregulated by bone morphogenetic protein 4 (显示 BMP4 ELISA试剂盒) in Hs578T cells and its upregulation may be facilited by serum-free cultivation or by three dimensional growth
Asporin promotes epithelial mesenchymal transformation, invasion, and migration of pancreatic cancer cellss by activating CD44 (显示 CD44 ELISA试剂盒)-AKT (显示 AKT1 ELISA试剂盒)/ERK (显示 EPHB2 ELISA试剂盒)-NF-kappaB (显示 NFKB1 ELISA试剂盒) pathway in paracrine and autocrine manner.
High ASPN expression in stroma is associated with prostate cancer progression.
To test the associations of ASPN variations with risk of subsequent oncologic outcomes.
Collectively, our findings indicate that ASPN is upregulated and plays an oncogenic role in gastric cancer progression and metastasis by influencing the EGFR (显示 EGFR ELISA试剂盒) signaling pathway.
Our results showed that ASPN rs13301537 T to C change and variant C genotype may contribute to knee OA risk in a Chinese Han population.
this is the first case-control study in Mexican women that suggests that menopause and the D-repeat polymorphism in the ASPN gene are associated with knee OA
Osteomodulin (显示 OMD ELISA试剂盒), osteoglycin (显示 OGN ELISA试剂盒), and asporin appear to be distinctly regulated in osteoarthritis labrum compared to OA cartilage.
Asporin may represent a new therapeutic target molecule for the development of drugs aimed at manipulating the cancer microenvironment.
Asporin deficiency changes skin glycosaminoglycan composition, and decorin (显示 DCN ELISA试剂盒) and biglycan (显示 BGN ELISA试剂盒) content, which may explain the changes in skin mechanical properties.
inhibition of TLR2 (显示 TLR2 ELISA试剂盒)- and TLR4 (显示 TLR4 ELISA试剂盒)-induced inflammatory responses and binding abilities to TLR2 (显示 TLR2 ELISA试剂盒) and TLR4 (显示 TLR4 ELISA试剂盒)
positively regulates FGF-2 (显示 FGF2 ELISA试剂盒) activity through a direct interaction
Findings suggest that asporin is one of the important cartilage matrix proteins that binds to the ECM (显示 MMRN1 ELISA试剂盒) and TGF-beta1 (显示 TGFB1 ELISA试剂盒) and thereby modulates interactions between TGF-beta (显示 TGFB1 ELISA试剂盒) and its signaling receptors.
PLAP-1/asporin plays a specific role in the periodontal ligament as a negative regulator of cytodifferentiation and mineralization by regulating BMP-2 (显示 BMP2 ELISA试剂盒) activity to prevent the periodontal ligament from developing non-physiological mineralization
The findings indicate that TGF-beta1 (显示 TGFB1 ELISA试剂盒) induces ASPN through Smad3 (显示 SMAD3 ELISA试剂盒) but that this induction is indirect.
Leucine-rich repeat motif 5 (LRR5) of PLAP-1/asporin, plays an important role in the PLAP-1/asporin-BMP-2 (显示 BMP2 ELISA试剂盒) interaction.
The small leucine-rich repeat secreted protein Asporin induces eyes in Xenopus embryos through the IGF signalling pathway.
Mapping of the OGN (显示 OGN ELISA试剂盒) and ASPN genes and association with growth and carcass traits.
This gene encodes a cartilage extracellular protein that is member of the small leucine-rich proteoglycan family. The encoded protein may regulate chondrogenesis by inhibiting transforming growth factor-beta 1-induced gene expression in cartilage. This protein also binds collagen and calcium and may induce collagen mineralization. Polymorphisms in the aspartic acid repeat region of this gene are associated with a susceptibility to osteoarthritis. Alternate splicing results in multiple transcript variants.
asporin (LRR class 1)
, asporin proteoglycan
, periodontal ligament associated protein 1
, small leucine-rich protein 1C
, biglycan-like protein 3
, periodontal ligament-associated protein 1