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The protein encoded by ARAP1 contains SAM, ARF-GAP, RHO-GAP, ankyrin repeat, RAS-associating, and pleckstrin homology (PH) domains. 再加上，我们可以发ARAP1 抗体 (46) 和 ARAP1 蛋白 (4)和数多这个蛋白质的别的产品。
Quantitative trait loci genes analysis reveals association between T2D risk variants at the ARAP1/STARD10 locus and STARD10 but not ARAP1 expression.
Increased ARAP (显示 INS ELISA试剂盒)1 expression might contribute to type 2 diabetes susceptibility at this Genome-wide association studies locus.
Arap1 is highly expressed in the renal vasculature, and its expression is suppressed by angiotensin II.
afadin (显示 MLLT4 ELISA试剂盒) regulates the cyclical activation and inactivation of Rap1 (显示 TERF2IP ELISA试剂盒), Rac1, and RhoA (显示 RHOA ELISA试剂盒) through SPA-1 and ARAP1.
Genetic variant rs1552224 of CENTD2 on chromosome 11 contributes to an independent effect as well as joint cumulative effect with rs2237897 of KCNQ1 on the risk of type 2 diabetes mellitus in Chinese Han population.
The proinsulin (显示 INS ELISA试剂盒)-decreasing and T2D-risk Alleles are associated with increased ARAP1 mRNA levels in primary human pancreatic islets.
a novel molecular mechanism of circular dorsal ruffles ring size control through the ARAP1-Arf1 (显示 ARF1 ELISA试剂盒)/5 pathway.
Of the lead variants from 12 novel type 2 diabetes associated loci, CENTD2 significantly associated with increased plasma glucose values and decreased glucose-stimulated insulin (显示 INS ELISA试剂盒) release.
ARAP1 associated with CIN85 (显示 SH3KBP1 ELISA试剂盒) affects epidermal growth factor receptor (显示 EGFR ELISA试剂盒) endocytic trafficking
PTK6 (显示 PTK6 ELISA试剂盒) enhances EGFR (显示 EGFR ELISA试剂盒) signaling by inhibition of EGFR (显示 EGFR ELISA试剂盒) down-regulation through phosphorylation of ARAP1 in breast cancer cells.
ARAP1 acts primarily on Arf6 (显示 ARF6 ELISA试剂盒) in vivo.
ARAP1 knockdown significantly compromises the localization of death receptor 4 at the cell surface of several tumor cell lines and slows down their TRAIL-induced death.
The protein encoded by this gene contains SAM, ARF-GAP, RHO-GAP, ankyrin repeat, RAS-associating, and pleckstrin homology (PH) domains. In vitro, this protein displays RHO-GAP and phosphatidylinositol (3,4,5) trisphosphate (PIP3)-dependent ARF-GAP activity. The encoded protein associates with the Golgi, and the ARF-GAP activity mediates changes in the Golgi and the formation of filopodia. It is thought to regulate the cell-specific trafficking of a receptor protein involved in apoptosis. Multiple transcript variants encoding different isoforms have been found for this gene.
centaurin delta 2
, centaurin, delta 2
, ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
, arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1
, ARF-GAP, RHO-GAP, ankyrin repeat, and pleckstrin homology domains-containing protein 1