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ANGPTL3 encodes a member of a family of secreted proteins that function in angiogenesis. 再加上，我们可以发ANGPTL3 试剂盒 (67) 和 ANGPTL3 蛋白 (28)和数多这个蛋白质的别的产品。
Showing 10 out of 176 products:
Human Polyclonal ANGPTL3 Primary Antibody for EIA, WB - ABIN452736
Shan, Yu, Liu, Hu, Sturgis, Miranda, Liu: The angiopoietin-like proteins ANGPTL3 and ANGPTL4 inhibit lipoprotein lipase activity through distinct mechanisms. in The Journal of biological chemistry 2009
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Human Polyclonal ANGPTL3 Primary Antibody for WB - ABIN390666
Shimamura, Matsuda, Kobayashi, Ando, Ono, Koishi, Furukawa, Makishima, Shimomura: Angiopoietin-like protein 3, a hepatic secretory factor, activates lipolysis in adipocytes. in Biochemical and biophysical research communications 2003
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Human Monoclonal ANGPTL3 Primary Antibody for ELISA, WB - ABIN165378
Ono, Shimizugawa, Shimamura, Yoshida, Noji-Sakikawa, Ando, Koishi, Furukawa: Protein region important for regulation of lipid metabolism in angiopoietin-like 3 (ANGPTL3): ANGPTL3 is cleaved and activated in vivo. in The Journal of biological chemistry 2003
Cow (Bovine) Polyclonal ANGPTL3 Primary Antibody for WB - ABIN2775402
Kathiresan, Melander, Guiducci, Surti, Burtt, Rieder, Cooper, Roos, Voight, Havulinna, Wahlstrand, Hedner, Corella, Tai, Ordovas, Berglund, Vartiainen, Jousilahti, Hedblad, Taskinen, Newton-Cheh et al.: Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans. ... in Nature genetics 2008
Knockdown of Angptl3 decreases liver size in developing zebrafish.
Our findings demonstrate that complete ANGPTL3 deficiency associates with highly reduced postprandial lipemia probably due to faster catabolism of intestinally derived lipoproteins, larger expansion of the postprandial FFA pool, and decreased influx of dietary-derived fatty acids into the liver. These results add information on mechanisms underlying hypolipidemia in familial combined hypolipidemia (FHBL2).
participants with heterozygous loss-of-function variants in ANGPTL3 had significantly lower serum levels of triglycerides, HDL (显示 HSD11B1 抗体) cholesterol, and LDL cholesterol than participants without these variants.
ANGPTL3 deficiency is associated with protection from coronary artery disease.
our data shows that ANGPTL3, 4 and 8 are increased in obesity and type 2 diabetes (T2D). ANGPTL8 associates with ANGPTL3 in the non-diabetic subjects while it associated more with ANGPTL4 (显示 ANGPTL4 抗体) in the obese and T2D subjects.
ANGPTL3 is specifically correlated with HDL (显示 HSD11B1 抗体)-c, apoA-I (显示 APOA1 抗体), SAA (显示 SAA1 抗体) and HDL (显示 HSD11B1 抗体) function in female non-diabetic participants. The decrease of ANGPTL3 level in female T2DM patients might contribute to its weak association to HDL (显示 HSD11B1 抗体) components and function.
The ANGPTL3 gene lies within DOCK7 (显示 DOCK7 抗体), although the variant is within non-coding regions outside of ANGPTL3, within DOCK7 (显示 DOCK7 抗体), suggesting complex long-range regulatory effects on gene expression in coronary artery disease.
ANGPTL3 levels were associated with fasting insulin (显示 INS 抗体) and the homeostasis model assessment of insulin (显示 INS 抗体) resistance in Korean children.
An ANGPTL3-4-8 model was proposed to explain the variations of lipoprotein lipase (LPL (显示 LPL 抗体)) activity during the fed-fast cycle. Feeding induces ANGPTL8, activating the ANGPTL8-ANGPTL3 pathway, which inhibits LPL (显示 LCP1 抗体) in cardiac and skeletal muscles to direct circulating triglycerides (TG) to white adipose tissue; the reverse is true during fasting, which suppresses ANGPTL8 but induces ANGPTL4 (显示 ANGPTL4 抗体), thereby directing TG to muscles.
Inactivation of ANGPTL3 reduces hepatic VLDL-triglyceride secretion
Novel mutation Y344S found in ANGPTL3 gene in two diabetic patients with familial hypobetalipoproteinemia.
This model suggests a general mechanism by which TAG trafficking is coordinated by lipasin, Angptl3 and Angptl4 (显示 ANGPTL4 抗体) at different nutritional statuses.
The deletion of ANGPTL3 tremendously attenuates proteinuria and protects podocytes from injury in a mouse model of adriamycin-induced nephropathy.
ANGPTL3 has a role in regulating white adipose tissue energy homeostasis but not in liver
Data indicate that expression of Angptl3 in hematopoietic stem cell (HSC (显示 FUT1 抗体)) through lentiviral transduction promoted HSC (显示 FUT1 抗体) expansion.
Angptl3 could induce actin filament rearrangement, mainly in lamellipodia formation, and that this process was mediated by integrin alpha(V)beta-mediated FAK and PI3K phosphorylation and Rac1 activation.
Furin (显示 FURIN 抗体) has a role as the primary in vivo convertase of ANGPTL3 and endothelial lipase (显示 LIPG 抗体) in hepatocytes
ANGPTL8, a paralog of ANGPTL3 that arose through duplication of an ancestral DOCK gene, regulates postprandial TAG and fatty acid metabolism by controlling activation of its progenitor, and perhaps other ANGPTLs
Angptl3, as an extrinsic factor, thus supports the stemness of hematopoietic stem cells in the bone marrow niche.
ANGPTL3 expression is upregulated in puromycin-induced podocyte damage and is associated with the reduction of perlecan (显示 HSPG2 抗体) and agrin (显示 AGRN 抗体) expression
First report of molecular cloning and characterization of ANGPTL3 in pigs, which will be helpful for a better understanding of the role of ANGPTLs in lipid metabolism.
This gene encodes a member of a family of secreted proteins that function in angiogenesis. The encoded protein, which is expressed predominantly in the liver, is further processed into an N-terminal coiled-coil domain-containing chain and a C-terminal fibrinogen chain. The N-terminal chain is important for lipid metablism, while the C-terminal chain may be involved in angiogenesis. Mutations in this gene cause familial hypobetalipoproteinemia type 2.
, WITHDRAWN: zgc:111943
, angiopoietin-related protein 3-like
, angiopoietin 5
, angiopoietin-related protein 3
, angiopoietin-like protein 3