anti-Adaptor Protein, phosphotyrosine Interaction, PH Domain and Leucine Zipper Containing 2 (APPL2) 抗体

The protein encoded by APPL2 is one of two effectors of the small GTPase RAB5A/Rab5, which are involved in a signal transduction pathway. 再加上,我们可以发Adaptor Protein, phosphotyrosine Interaction, PH Domain and Leucine Zipper Containing 2 蛋白 (5)和数多这个蛋白质的别的产品。

列出全部抗体 基因 基因ID UniProt
APPL2 362860  
APPL2 55198 Q8NEU8
APPL2 216190 Q8K3G9

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Showing 10 out of 33 products:

产品编号 适用 宿主 标记 应用范围 图像 规格 供应商 交付 价格 详细
非结合性 WB Western blot analysis of APPL2 Antibody (N-term) Pab  pre-incubated without(lane 1) and with(lane 2) blocking peptide in NCI-H292 cell line lysate. APPL2 Antibody (N-term) (arrow) was detected using the purified Pab. 400 μL Log in to see 5至8个工作日
¥2,325.14
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非结合性 WB Western Blot: DIP13B Antibody [NBP2-16165] - Sample (30 ug of whole cell lysate) A: NT2D1 B: IMR32 7. 5% SDS PAGE gel, diluted at 1:1000. 0.1 mL Log in to see 26至33个工作日
¥3,655.56
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非结合性 ICC, IF, IHC, IHC (p), WB Immunohistochemistry-Paraffin: DIP13B Antibody [NBP2-16164] - Immunohistochemical analysis of paraffin-embedded HBL435 xenograft, using antibody at 1:100 dilution. Western Blot: DIP13B Antibody [NBP2-16164] - Sample (30 ug of whole cell lysate) A: NT2D1 B: IMR32 7. 5% SDS PAGE gel, diluted at 1:1000. 0.1 mL Log in to see 26至33个工作日
¥3,655.56
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小鼠 非结合性 IF, WB Western Blot analysis of APPL2 expression in transfected 293T cell line by APPL2 MaxPab polyclonal antibody.Lane 1: APPL2 transfected lysate(73.04 KDa).Lane 2: Non-transfected lysate. APPL2 MaxPab polyclonal antibody. Western Blot analysis of APPL2 expression in rat brain. 50 μg Log in to see 29至34个工作日
¥3,169.73
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非结合性 IHC, IHC (p), WB Immunohistochemistry-Paraffin: DIP13B Antibody [NBP2-14303] - Staining of human heart muscle shows strong cytoplasmic positivity in myocytes. Western Blot: DIP13B Antibody [NBP2-14303] - Lane 1: Marker [kDa] 250, 130, 95, 72, 55, 36, 28, 17, 10.Lane 2: Negative control (vector only transfected HEK293T lysate).Lane 3: Over-expression lysate (Co-expressed with a C-terminal myc-DDK tag (~3.1 kDa) in mammalian HEK293T cells, LY413268) 0.1 mL Log in to see 28至35个工作日
¥3,591.24
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小鼠 非结合性 IF, ELISA, WB Detection limit for recombinant GST tagged APPL2 is 0.3 ng/ml as a capture antibody. Western Blot analysis of APPL2 expression in transfected 293T cell line by APPL2 monoclonal antibody (M06), clone 1C10.Lane 1: APPL2 transfected lysate (Predicted MW: 74.5 KDa).Lane 2: Non-transfected lysate. 100 μg Log in to see 29至34个工作日
¥3,169.73
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非结合性 ELISA, WB   200 μL Log in to see 29至35个工作日
¥7,803.92
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HRP ELISA, WB   200 μL Log in to see 29至35个工作日
¥9,863.01
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Biotin ELISA, WB   200 μL Log in to see 29至35个工作日
¥9,863.01
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PE ELISA, WB   200 μL Log in to see 29至35个工作日
¥9,863.01
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通过反应活性、应用领域、克隆类型和共轭标记 APPL2 抗体

特性 应用范围 宿主 克隆类型 标记
Rat (Rattus) ,
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Human ,
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Mouse (Murine) ,


引用最多的anti-Adaptor Protein, phosphotyrosine Interaction, PH Domain and Leucine Zipper Containing 2 抗体

  1. Human Polyclonal APPL2 Primary Antibody for IF, WB - ABIN527414 : Cleasby, Lau, Polkinghorne, Patel, Leslie, Turner, Cooney, Xu, Kraegen: The adaptor protein APPL1 increases glycogen accumulation in rat skeletal muscle through activation of the PI3-kinase signalling pathway. in The Journal of endocrinology 2011 (PubMed)

更多抗Adaptor Protein, phosphotyrosine Interaction, PH Domain and Leucine Zipper Containing 2的相互作用对抗体

Human Adaptor Protein, phosphotyrosine Interaction, PH Domain and Leucine Zipper Containing 2 (APPL2) interaction partners

  1. Results show the suppressive effect of OCC-1 RNA on transcription level of the APPL2 (显示 APLP2 抗体) gene provides a putative colorectal neoplasm progression index.

  2. Data show that signal transducing adaptor proteins APPL1 and APPL2 are required for TGFbeta-induced nuclear translocation of TGFbeta type I receptor (TbetaRI)-ICD and for cancer cell invasiveness of prostate and breast cancer cell lines.

  3. ATM (显示 ATM 抗体) is the central modulator of APPL (显示 APPL1 抗体)-mediated effects on radiosensitivity and DNA repair.

  4. It concludes that APPL2 (显示 APLP2 抗体)(PH) binding to BAR domain and Reptin (显示 RUVBL2 抗体) is mutually exclusive which regulates the nucleocytoplasmic shuttling of Reptin (显示 RUVBL2 抗体).

  5. C-APPL1 (显示 APPL1 抗体)/A-APPL2 (显示 APLP2 抗体) allele combination is associated with non-alcoholic fatty liver disease occurrence, with a more severe hepatic steatosis grade and with a reduced adiponectin (显示 ADIPOQ 抗体) cytoprotective effect on liver.

  6. Data indicate that a high level of APPL2 (显示 APLP2 抗体) protein might enhance glioblastoma growth by maintaining low expression level of genes responsible for cell death induction.

  7. analysis of APPL1 (显示 APPL1 抗体) and APPL2 (显示 APLP2 抗体) proteins and their interaction with Rab (显示 HRB 抗体)

  8. Genetic variation(s) in APPL1 (显示 APPL1 抗体)/2 may be associated with CAD (显示 CAD 抗体) risk in T2DM in Chinese population.

  9. Data suggest that although annexin A2 (显示 ANXA2 抗体) is not an exclusive marker of APPL1 (显示 APPL1 抗体)/2 endosomes, it has an important function in membrane recruitment of APPL (显示 APPL1 抗体) proteins, acting in parallel to Rab5 (显示 RAB5A 抗体).

  10. significant fluorescence resonance energy transfer between APPL (显示 APPL1 抗体) minimal BAR domain FRET pairs

Mouse (Murine) Adaptor Protein, phosphotyrosine Interaction, PH Domain and Leucine Zipper Containing 2 (APPL2) interaction partners

  1. Appl1 (显示 APPL1 抗体)/2-null mouse embryonic fibroblasts exhibited defects in HGF (显示 HGF 抗体)-induced Akt (显示 AKT1 抗体) activation, migration, and invasion.

  2. Rab31 (显示 RAB31 抗体), with APPL2 as its effector, play a role in FcgammaR-mediated phagocytosis through PI3K/Akt (显示 AKT1 抗体) signaling in macrophages.

Adaptor Protein, phosphotyrosine Interaction, PH Domain and Leucine Zipper Containing 2 (APPL2) 抗原简介

蛋白简介

The protein encoded by this gene is one of two effectors of the small GTPase RAB5A/Rab5, which are involved in a signal transduction pathway. Both effectors contain an N-terminal Bin/Amphiphysin/Rvs (BAR) domain, a central pleckstrin homology (PH) domain, and a C-terminal phosphotyrosine binding (PTB) domain, and they bind the Rab5 through the BAR domain. They are associated with endosomal membranes and can be translocated to the nucleus in response to the EGF stimulus. They interact with the NuRD/MeCP1 complex (nucleosome remodeling and deacetylase /methyl-CpG-binding protein 1 complex) and are required for efficient cell proliferation. A chromosomal aberration t(12\;22)(q24.1\;q13.3) involving this gene and the PSAP2 gene results in 22q13.3 deletion syndrome, also known as Phelan-McDermid syndrome.

Gene names and symbols associated with APPL2

  • adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2 (Appl2) 抗体
  • adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2 (APPL2) 抗体
  • adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2 (appl2) 抗体
  • amyloid beta (A4) precursor-like protein 2 (APLP2) 抗体
  • APPL2 抗体
  • Dip3b 抗体
  • DIP13B 抗体
  • MGC84621 抗体
  • RGD1563028 抗体

Protein level used designations for APPL2

DCC-interacting protein 13-beta , adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2 , amyloid beta (A4) precursor-like protein 2 , DIP13 beta , adapter protein containing PH domain, PTB domain and leucine zipper motif 2 , Dip3 beta , dip13-beta

GENE ID SPECIES
362860 Rattus norvegicus
418075 Gallus gallus
447596 Xenopus laevis
515605 Bos taurus
100000135 Danio rerio
100127202 Xenopus (Silurana) tropicalis
100545199 Meleagris gallopavo
100563730 Anolis carolinensis
100604575 Nomascus leucogenys
55198 Homo sapiens
216190 Mus musculus
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