Adaptor Protein, phosphotyrosine Interaction, PH Domain and Leucine Zipper Containing 1 蛋白 (APPL1)

The protein encoded by APPL1 has been shown to be involved in the regulation of cell proliferation, and in the crosstalk between the adiponectin signalling and insulin signalling pathways. 再加上,我们可以发Adaptor Protein, phosphotyrosine Interaction, PH Domain and Leucine Zipper Containing 1 抗体 (67)和数多这个蛋白质的别的产品。

列出全部蛋白 基因 基因ID UniProt
APPL1 26060 Q9UKG1
APPL1 72993 Q8K3H0
大鼠 APPL1 APPL1 290537  

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Insect Cells 小鼠 His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 78至82个工作日
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Insect Cells His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 78至82个工作日
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APPL1 蛋白 by Origin and Source

Origin 在表达 标记
Human , ,
, ,
Mouse (Murine)

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Human Adaptor Protein, phosphotyrosine Interaction, PH Domain and Leucine Zipper Containing 1 (APPL1) interaction partners

  1. APPL1 positively mediated leptin (显示 LEP 蛋白) signaling.

  2. Decreased expression of APPL1 is associated with polycystic ovary syndrome.

  3. Results indicate that persistent rab5 (显示 RAB5A 蛋白) overactivation through beta-cleaved carboxy-terminal fragment of APP (显示 APP 蛋白)-APPL1 interactions constitutes a novel APP (显示 APP 蛋白)-dependent pathogenic pathway in Alzheimer's disease

  4. Data show that signal transducing adaptor proteins APPL1 and APPL2 are required for TGFbeta-induced nuclear translocation of TGFbeta type I receptor (TbetaRI)-ICD and for cancer cell invasiveness of prostate and breast cancer cell lines.

  5. Low expression of APPL1 is associated with metastasis in prostate cancer.

  6. APPL1 endosomes represent a distinct population of Rab5 (显示 RAB5A 蛋白)-positive sorting endosomes.

  7. article provides evidence that GG genotype and G carrier (CG+GG) genotypes of the rs4640525 polymorphism in the APPL1 gene may be suitable susceptibility biomarkers for NAFLD

  8. Two loss-of-function mutations in APPL1, identified by means of whole-exome sequencing, found in two large families with a high prevalence of Familial Diabetes Mellitus.

  9. A role for APPL1 in TLR3 (显示 TLR3 蛋白)/4-dependent TBK1 (显示 TBK1 蛋白) and IKKepsilon (显示 IKBKE 蛋白) activation in macrophages.

  10. ATM (显示 ATM 蛋白) is the central modulator of APPL-mediated effects on radiosensitivity and DNA repair.

Mouse (Murine) Adaptor Protein, phosphotyrosine Interaction, PH Domain and Leucine Zipper Containing 1 (APPL1) interaction partners

  1. Appl1/2-null mouse embryonic fibroblasts exhibited defects in HGF (显示 HGF 蛋白)-induced Akt (显示 AKT1 蛋白) activation, migration, and invasion.

  2. In experimental high glucose condition APPL1 acts as a protective factor against podocytes injury through regulating AMPK (显示 PRKAA1 蛋白) signaling.

  3. A role for APPL1 in TLR3 (显示 TLR3 蛋白)/4-dependent TBK1 (显示 TBK1 蛋白) and IKKepsilon (显示 IKBKE 蛋白) activation in macrophages.

  4. APPL1 sensitizes insulin (显示 INS 蛋白) signaling by acting at a site downstream of the IR. Study uncovers a mechanism regulating insulin (显示 INS 蛋白) signaling and crosstalk between the insulin (显示 INS 蛋白) and adiponectin (显示 ADIPOQ 蛋白) pathways.

  5. Study demonstrates the roles of APPL1 in regulating GSIS and mitochondrial function in pancreatic beta cells, which implicates APPL1 as a therapeutic target in the treatment of type 2 diabetes.

  6. APPL1 transgenic mice exhibit improved peripheral metabolism, reduced cardiac lipotoxicity, and improved insulin (显示 INS 蛋白) sensitivity.

  7. Our findings demonstrate that exercise training performed concomitantly to a high-fat diet reduces the degree of insulin (显示 INS 蛋白) resistance and improves adipoR1 (显示 ADIPOR1 蛋白)-2/APPL1 protein levels in the hepatic, adipose, and skeletal muscle tissue

  8. APPL1 contributes to connecting synaptic NMDA receptors with the intracellular phosphoinositide 3-kinase /Akt (显示 AKT1 蛋白) cascade in neurons.

  9. Reduced APPL1 expression in pancreatic islets may serve as a pathological link that couples insulin (显示 INS 蛋白) resistance to beta-cell dysfunction in type 2 diabetes.

  10. Endurance training was able to increase APPL1 expression.

蛋白简介Adaptor Protein, phosphotyrosine Interaction, PH Domain and Leucine Zipper Containing 1 (APPL1)

蛋白简介

The protein encoded by this gene has been shown to be involved in the regulation of cell proliferation, and in the crosstalk between the adiponectin signalling and insulin signalling pathways. The encoded protein binds many other proteins, including RAB5A, DCC, AKT2, PIK3CA, adiponectin receptors, and proteins of the NuRD/MeCP1 complex. This protein is found associated with endosomal membranes, but can be released by EGF and translocated to the nucleus.

Gene names and symbols associated with APPL1

  • adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1 (APPL1)
  • adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1 (Appl1)
  • 2900057D21Rik 蛋白
  • 7330406P05Rik 蛋白
  • AI585782 蛋白
  • APPL 蛋白
  • AW209077 蛋白
  • BB022931 蛋白
  • C88264 蛋白
  • DIP13 蛋白
  • DIP13alpha 蛋白
  • RGD1309388 蛋白

Protein level used designations for APPL1

AKT2 interactor , DCC-interacting protein 13-alpha , adapter protein containing PH domain, PTB domain and leucine zipper motif 1 , adaptor protein containing pH domain, PTB domain and leucine zipper motif 1 , dip13-alpha , signaling adaptor protein DIP13alpha , DIP13 alpha , adaptor protein APPL like

GENE ID SPECIES
100058653 Equus caballus
26060 Homo sapiens
484716 Canis lupus familiaris
517850 Bos taurus
72993 Mus musculus
290537 Rattus norvegicus
100188978 Sus scrofa
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