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The protein encoded by APPL1 has been shown to be involved in the regulation of cell proliferation, and in the crosstalk between the adiponectin signalling and insulin signalling pathways. 再加上，我们可以发Adaptor Protein, phosphotyrosine Interaction, PH Domain and Leucine Zipper Containing 1 抗体 (69) 和 Adaptor Protein, phosphotyrosine Interaction, PH Domain and Leucine Zipper Containing 1 蛋白 (5)和数多这个蛋白质的别的产品。
APPL1 positively mediated leptin (显示 LEP ELISA试剂盒) signaling.
Decreased expression of APPL1 is associated with polycystic ovary syndrome.
Results indicate that persistent rab5 (显示 RAB5A ELISA试剂盒) overactivation through beta-cleaved carboxy-terminal fragment of APP (显示 APP ELISA试剂盒)-APPL1 interactions constitutes a novel APP (显示 APP ELISA试剂盒)-dependent pathogenic pathway in Alzheimer's disease
Data show that signal transducing adaptor proteins APPL1 and APPL2 are required for TGFbeta-induced nuclear translocation of TGFbeta type I receptor (TbetaRI)-ICD and for cancer cell invasiveness of prostate and breast cancer cell lines.
Low expression of APPL1 is associated with metastasis in prostate cancer.
APPL1 endosomes represent a distinct population of Rab5 (显示 RAB5A ELISA试剂盒)-positive sorting endosomes.
article provides evidence that GG genotype and G carrier (CG+GG) genotypes of the rs4640525 polymorphism in the APPL1 gene may be suitable susceptibility biomarkers for NAFLD (显示 TSC2 ELISA试剂盒)
Two loss-of-function mutations in APPL1, identified by means of whole-exome sequencing, found in two large families with a high prevalence of Familial Diabetes Mellitus.
A role for APPL1 in TLR3 (显示 TLR3 ELISA试剂盒)/4-dependent TBK1 (显示 TBK1 ELISA试剂盒) and IKKepsilon (显示 IKBKE ELISA试剂盒) activation in macrophages.
ATM (显示 ATM ELISA试剂盒) is the central modulator of APPL-mediated effects on radiosensitivity and DNA repair.
APPL1-SirT1 (显示 SIRT1 ELISA试剂盒)-STAT3 (显示 STAT3 ELISA试剂盒) pathway mediated adiponectin (显示 ADIPOQ ELISA试剂盒) signaling in primary hepatocytes.
Here we establish potential roles for APPL1 and 2 signaling adaptors as regulators of LPS/TLR4 (显示 TLR4 ELISA试剂盒)-induced signaling, transcription, and cytokine secretion.
Appl1/2-null mouse embryonic fibroblasts exhibited defects in HGF (显示 HGF ELISA试剂盒)-induced Akt (显示 AKT1 ELISA试剂盒) activation, migration, and invasion.
In experimental high glucose condition APPL1 acts as a protective factor against podocytes injury through regulating AMPK (显示 PRKAA1 ELISA试剂盒) signaling.
APPL1 sensitizes insulin (显示 INS ELISA试剂盒) signaling by acting at a site downstream of the IR. Study uncovers a mechanism regulating insulin (显示 INS ELISA试剂盒) signaling and crosstalk between the insulin (显示 INS ELISA试剂盒) and adiponectin (显示 ADIPOQ ELISA试剂盒) pathways.
Study demonstrates the roles of APPL1 in regulating GSIS and mitochondrial function in pancreatic beta cells, which implicates APPL1 as a therapeutic target in the treatment of type 2 diabetes.
APPL1 transgenic mice exhibit improved peripheral metabolism, reduced cardiac lipotoxicity, and improved insulin (显示 INS ELISA试剂盒) sensitivity.
Our findings demonstrate that exercise training performed concomitantly to a high-fat diet reduces the degree of insulin (显示 INS ELISA试剂盒) resistance and improves adipoR1 (显示 ADIPOR1 ELISA试剂盒)-2/APPL1 protein levels in the hepatic, adipose, and skeletal muscle tissue
APPL1 contributes to connecting synaptic NMDA receptors with the intracellular phosphoinositide 3-kinase /Akt (显示 AKT1 ELISA试剂盒) cascade in neurons.
The protein encoded by this gene has been shown to be involved in the regulation of cell proliferation, and in the crosstalk between the adiponectin signalling and insulin signalling pathways. The encoded protein binds many other proteins, including RAB5A, DCC, AKT2, PIK3CA, adiponectin receptors, and proteins of the NuRD/MeCP1 complex. This protein is found associated with endosomal membranes, but can be released by EGF and translocated to the nucleus.
, DCC-interacting protein 13-alpha
, adapter protein containing PH domain, PTB domain and leucine zipper motif 1
, adaptor protein containing pH domain, PTB domain and leucine zipper motif 1
, signaling adaptor protein DIP13alpha
, DIP13 alpha
, adaptor protein APPL like