Activity-Regulated Cytoskeleton-Associated Protein 蛋白 (Arc)

Plays a role in the regulation of cell morphology and cytoskeletal organization. 再加上,我们可以发Arc 抗体 (38)Arc 试剂盒 (14)和数多这个蛋白质的别的产品。

列出全部蛋白 基因 基因ID UniProt
Arc 11838 Q9WV31
Arc 23237 Q7LC44
Arc 54323 Q63053
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HEK-293 Cells Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 10至12个工作日
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大肠杆菌(E. Coli) 小鼠 His tag   50 μg Log in to see 13至16个工作日
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大肠杆菌(E. Coli) 非结合性 100 μg Log in to see 13至16个工作日
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Arc 蛋白 by Origin and Source

Origin 在表达 标记
Mouse (Murine)

Human ,

Rat (Rattus)

更多Activity-Regulated Cytoskeleton-Associated Protein (Arc)互动伙伴

Mouse (Murine) Activity-Regulated Cytoskeleton-Associated Protein (Arc) interaction partners

  1. CTCF (显示 CTCF 蛋白) knockdown attenuates fear-conditioning-induced hippocampal gene expression of key learning genes and loss of long-range interactions at the BDNF (显示 BDNF 蛋白) and Arc (显示 NOL3 蛋白) loci.

  2. Genetic disruption of Arc (显示 NOL3 蛋白) in mice causes alterations in dopamine and neurobehavioral phenotypes related to schizophrenia.

  3. Data indicate that ARC (显示 NOL3 蛋白) overexpression diminishes amyloid-induced JNK (显示 MAPK8 蛋白) pathway activation and apoptosis in the beta-cell, a strategy that may reduce beta-cell loss in type 2 diabetes

  4. Activity-regulated cytoskeleton-associated protein accumulates in the nucleus in response to cocaine and acts as a brake on chromatin remodeling and long-term behavioral alterations.

  5. This is a promising novel therapeutic approach because it appears to be effective in a model producing severe injury by interfering with an array of proximal signals and effectors of the ischemic cascade, upstream of JNK (显示 MAPK8 蛋白), caspases, and BIM (显示 BCL2L11 蛋白) and BAX (显示 BAX 蛋白) activation.

  6. missense mutations in TRIAD3 abolished the interaction of TRIAD3A with Arc (显示 NOL3 蛋白), disrupting Arc (显示 NOL3 蛋白) ubiquitination, and consequently Arc (显示 NOL3 蛋白) degradation.

  7. The dynamics of the c-Fos and Arc (显示 NOL3 蛋白) expression has a biphasic pattern: the first peak was observed in 15-30 min after learning and the second less pronounced peak in 1-3 h.

  8. we report that late Arc (显示 NOL3 蛋白) expression is essential for the persistence of newly-acquired and reactivated memories. Persistent fear memories could be a factor in post-traumatic stress disorder.

  9. Arc (显示 NOL3 蛋白)-expressing neurons have enhanced intrinsic excitability and are preferentially recruited into newly encoded memory traces.

  10. These findings suggest that 11beta-HSD1 (显示 HSD11B1 蛋白) may contribute to the decline in Npas4 (显示 NPAS4 蛋白) and Arc (显示 NOL3 蛋白) mRNA levels associated with memory impairment during ageing

Human Activity-Regulated Cytoskeleton-Associated Protein (Arc) interaction partners

  1. missense mutations in TRIAD3 abolished the interaction of TRIAD3A with Arc (显示 NOL3 蛋白), disrupting Arc (显示 NOL3 蛋白) ubiquitination, and consequently Arc (显示 NOL3 蛋白) degradation.

  2. ARC (显示 NOL3 蛋白) confers resistance to sunitinib in renal cell carcinoma (显示 MOK 蛋白) through alternate angiogenesis pathways

  3. We tested whether ARC (显示 NOL3 蛋白) variants are associated with six measures of cognitive functioning in 670 healthy subjects in the Norwegian Cognitive NeuroGenetics (NCNG) by extracting data from its Genome-Wide Association Study (GWAS).

  4. this is the first report associating an ARC (显示 NOL3 蛋白) SNP with schizophrenia and supports recent large-scale GWAS findings implicating the ARC (显示 NOL3 蛋白) complex in schizophrenia risk

  5. we propose that the peculiar characteristics of Arc (显示 NOL3 蛋白) protein, such as its optimal expression after ongoing experience or familiar behavior could explain how familiarization and recognition memories are stored and preserved in the mammalian brain--{REVIEW}

  6. mRNA levels of ARC (显示 NOL3 蛋白) and SGK1 (显示 SGK1 蛋白) did not differ significantly between the schizophrenia or control samples.

  7. Arc (显示 NOL3 蛋白) is a flexible multi-domain protein that exists in monomeric and oligomeric forms, compatible with a diverse, hub-like role in plasticity-related processes.

  8. Results show that in response to DNA damage, p53 (显示 TP53 蛋白) total levels increase proportionally to the strength of the damage; however, p53 (显示 TP53 蛋白) tetramers are formed at a constant rate under the control of ARC (显示 NOL3 蛋白) protein.

  9. Degradation of Arc (显示 NOL3 蛋白) by clathrin-localized Triad3A regulates the availability of synaptic AMPA (显示 GRIA3 蛋白) receptors.

  10. we report a novel ARC (显示 NOL3 蛋白) single nucleotide polymorphism associated with a reduced risk of developing Alzheimer disease.

蛋白简介Arc

蛋白简介

Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the stress fiber dynamics and cell migration (By similarity). Required for consolidation of synaptic plasticity as well as formation of long-term memory. Regulates endocytosis of AMPA receptors in response to synaptic activity. Required for homeostatic synaptic scaling of AMPA receptors.

Gene names and symbols associated with Arc

  • activity regulated cytoskeleton associated protein (ARC)
  • activity-regulated cytoskeleton-associated protein (arc)
  • activity regulated cytoskeletal-associated protein (Arc)
  • activity-regulated cytoskeleton-associated protein (Arc)
  • ARC 蛋白
  • Arc3.1 蛋白
  • ARG3.1 蛋白
  • C86064 蛋白
  • mArc 蛋白
  • rg3.1 蛋白

Protein level used designations for Arc

activity-regulated cytoskeleton-associated protein , activity-regulated cytoskeleton-associated-like protein , ARC/ARG3.1 , activity-regulated gene 3.1 protein homolog , activity regulated cytoskeletal-associated protein , activity-regulated gene 3.1 protein , arg3.1

GENE ID SPECIES
472874 Pan troglodytes
519403 Bos taurus
752001 Taeniopygia guttata
100271754 Xenopus (Silurana) tropicalis
11838 Mus musculus
23237 Homo sapiens
54323 Rattus norvegicus
395075 Gallus gallus
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