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The membrane-associated protein encoded by ABCB1B is a member of the superfamily of ATP-binding cassette (ABC) transporters. 再加上，我们可以发ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1B 蛋白 (11)和数多这个蛋白质的别的产品。
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Human Polyclonal ABCB1B Primary Antibody for FACS, IF (p) - ABIN670161
Hu, Peng, Li: The expression and significance of P-glycoprotein, lung resistance protein and multidrug resistance-associated protein in gastric cancer. in Journal of experimental & clinical cancer research : CR 2009
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Compared with the sensitive group, both mdr1 (显示 TBC1D9 抗体) mRNA and P-gp (显示 ABCB4 抗体) expressions increased in the resistant group
an SNP in ABCB1 (显示 ABCB1 抗体) (rs2032582: 2677G > T/A) was significantly associated with atorvastatin-induced liver injury (AILI) indicating that the G allele might be a risk factor for AILI in Japanese population
impact of CYP4F2 (显示 CYP4F2 抗体), ABCB1 (显示 ABCB1 抗体), and GGCX (显示 GGCX 抗体) polymorphisms on bleeding episodes associated with acenocoumarol in Russian patients with atrial fibrillation
Collectively, the data establish a hitherto unknown liaison among MDR1 (显示 TBC1D9 抗体), BMI1 (显示 BMI1 抗体) and TIP60 (显示 KAT5 抗体) and provide mechanistic insights into cisplatin-induced MDR1 (显示 TBC1D9 抗体) expression resulting in acquired cross-resistance against paclitaxel, doxorubicin and likely other anticancer drugs.
High ABCB1 (显示 ABCB1 抗体) expression is associated with hepatocellular carcinoma.
Our data suggest that the C1236T and G2677A/T SNPs in the MDR1 (显示 TBC1D9 抗体) gene are associated with Crohn's disease and the C1236T risk allele with a more severe course of disease in Algerian pediatric patients.
ATPase (显示 DNAH8 抗体) measurements imply that DCV and Ho are similarly handled by ABCB1 (显示 ABCB1 抗体), whereas ABCG2 (显示 ABCG2 抗体) seems to transport DVC more effectively. In addition, we have developed an image-based high content microscopy screening method for simultaneous in situ measurement of the cellular activity and expression of the ABCG2 (显示 ABCG2 抗体) multidrug transporter
These results show that multidrug resistant leukemia cell microparticle regulation of ABCC1 (显示 ABCC1 抗体) in recipient cells is governed by the transfer of both miR (显示 MLXIP 抗体)-326 and ABCB1 (显示 ABCB1 抗体) from donor cells
he modulatory effect of acacetin-doxorubicin combination on doxorubicin influx and efflux was mediated through downregulation of MDR1 (显示 TBC1D9 抗体) treansporter in non-small-cell lung carcinoma (NSCLC) cells.
An additional action of osimertinib that directly inhibits the function of ABCB1 (显示 ABCB1 抗体).
Loss of ABCB1 (显示 ABCB1 抗体) expression is associated with neonatal hyperbilirubinemia.
the high-affinity site of P-glycoprotein is inaccessible because of either a conformational change or binding of detergent at the binding site in a detergent micelle environment; ligands bind to a low-affinity site, resulting in altered modulation of P-gp (显示 ABCB4 抗体) ATPase (显示 DNAH8 抗体) activity
Data suggest that ATP binding to Abcb1b/P-glycoprotein (Pgp) in liposomes exhibits cooperativity with verapamil (a cardiovascular/antiarrhythmia drug); cooperativity between verapamil and a nonhydrolyzable ATP analog (AMPPNP) leads to distinct global conformational changes in Abcb1b/Pgp.
Chrysosplenetin inhibited P-gp (显示 ABCB4 抗体) activity and reverse the up-regulated P-gp (显示 ABCB4 抗体) and MDR1 (显示 ABCB4 抗体) levels induced by artemisinin.
Tamsulosin and tolterodine with P-gp (显示 ABCB4 抗体) gene expression and activity in an enantiomer-specific way.
Pgp (显示 ABCB4 抗体)-coupled ATPase (显示 DNAH8 抗体) activity kinetics measured with a range of verapamil and digoxin concentrations fit well to a DDI model encompassing non-competitive and competitive inhibition of digoxin by verapamil.
Data show that human transgenic mutant huntingtin (显示 HTT 抗体) (mHtt) aggregation might be regulated by multidrug resistance protein 1 (MDR1 (显示 ABCB4 抗体)) which suggests that MDR1 (显示 ABCB4 抗体) might be a potential therapeutic target for Huntington's disease.
In vitro and in vivo downregulation of the ATP binding cassette transporter (显示 ABCC3 抗体) B1 by the HMG-CoA reductase (显示 HMGCR 抗体) inhibitor simvastatin
Efficient chemoprotection of CDD (显示 CDA 抗体) and MDR1 (显示 ABCB4 抗体) transduced hematopoietic 32D as well as primary lin(-) cells was proven in the context of Ara (显示 FOXC1 抗体)-C and anthracycline application
These study data have facilitated understanding of the molecular mechanisms of neurotoxicosis in ABCB1 (显示 ABCB1 抗体)-1Delta mutant mice following exposure to various P-gp (显示 ABCB4 抗体) substrates.
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier.
, colchicin sensitivity
, doxorubicin resistance
, multidrug resistance protein 1
, ATP-binding cassette sub-family B member 1
, P glycoprotein 1
, multidrug resistance protein 1B
, ATP-binding cassette sub-family B (MDR/TAP) member 1 (P-glycoprotein/multidrug resistance 1)
, ATP-binding cassette, sub-family B (MDR/TAP), member 1 (P-glycoprotein/multidrug resistance 1)
, ATP-binding cassette, sub-family B (MDR/TAP), member 1B
, ATP-binding cassette, subfamily B, member 1B
, P-glycoprotein/multidrug resistance 1