ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 11 (ABCB11) ELISA试剂盒

The membrane-associated protein encoded by ABCB11 is a member of the superfamily of ATP-binding cassette (ABC) transporters. 再加上,我们可以发ABCB11 抗体 (60)ABCB11 蛋白 (8)和数多这个蛋白质的别的产品。

list all ELISA KIts 基因 基因ID UniProt
ABCB11 8647 O95342
ABCB11 27413 Q9QY30
ABCB11 83569 O70127
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7.8 pg/mL 31.25-2000 pg/mL Typical standard curve 96 Tests Log in to see 15至18个工作日
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适于 ABCB11 相互作用对的更多 ELISA 试剂盒

Rainbow Trout (Oncorhynchus mykiss) ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 11 (ABCB11) interaction partners

  1. Data show the gene expression profiling of ABC (显示 ABCB6 ELISA试剂盒) transporters in seven tissues.

  2. cloned one partial and two full gene sequences, which show high degree of identity with mammalian Pgp1 (ABCB1 (显示 ABCB1 ELISA试剂盒)), BSEP (ABCB11) and MRP2 (ABCC2 (显示 ABCC2 ELISA试剂盒)) efflux transporters and found identical relative expression patterns for both liver and primary hepatocytes

Human ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 11 (ABCB11) interaction partners

  1. Case Report: compound heterozygotes for two missense mutations of the ABCB11 with a mild form of progressive familial intrahepatic cholestasis type 2.

  2. Patients with a confirmed ABCB11 or tight junction protein 2 (显示 TJP2 ELISA试剂盒) gene mutation (n = 7) had a minimally detectable THBA proportion (0.23-2.99% of total BAs). Three patients with an ATP8B1 (显示 ATP8B1 ELISA试剂盒) mutation had an elevated THBA proportion (7.51-37.26%).

  3. By these complementary approaches, a set of ten novel BSEP interaction partners was identified. With the exception of radixin (显示 RDX ELISA试剂盒), all other interaction partners were integral or membrane-associated proteins including proteins of the early secretory pathway and the bile acyl-CoA synthetase (显示 SLC27A5 ELISA试剂盒), the second to last, ER-associated enzyme of bile salt synthesis

  4. Among the Han individuals aged over 40 years in Hunan, China, genotype CC or CT of BSEP gene SNP rs2287622 may correlate with higher risk of chronic hepatitis C in comparison with genotype TT.

  5. Case Reports: late onset progressive familial intrahepatic cholestasis 2 secondary to novel ABCB11 mutations.

  6. Negative immunoreaction of BSEP was found in the majority of the progressive familial intrahepatic cholestasis (PFIC (显示 ATP8B1 ELISA试剂盒)) group. Nonetheless, the negative immunoreaction was demonstrated in a considerable number of the non-PFIC (显示 ATP8B1 ELISA试剂盒) group.BSEP immunoreaction was negative in the majority (82.4%) of PFIC2 but in none of the two patients with PFIC1 (显示 ATP8B1 ELISA试剂盒).

  7. The results revealed that functional impairment of BSEP predisposes the cells to altered BA disposition and is a susceptive factor to drug-induced cholestatic injury.

  8. Results identified six novel mutations (PKHD1: p.Thr777Met, p.Tyr2260Cys; ABCB11: p.Val1112Phe, c.611+1G > A, p.Gly628Trpfs*3 and NPC1 (显示 NPC1 ELISA试剂盒): p.Glu391Lys) for the diagnostic of inherited infantile cholestatic disorders.

  9. Report highly specific expression of BSEP and MDR3 (显示 ABCB4 ELISA试剂盒) in hepatocellular carcinoma.

  10. GGT levels in patients with ATP8B1 or ABCB11 deficiency varied with age. The peak GGT value was <70U/L in the 2nd~6th month of life, <60U/L in the 7th~12th month and <50U/L beyond one year

Mouse (Murine) ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 11 (ABCB11) interaction partners

  1. Isoniazid/rifampicin administration significantly down-regulated the expression of hepatic bile acids transporters Ntcp (显示 SLC10A1 ELISA试剂盒) and Bsep in liver.

  2. mechanism of increased biliary lipid secretion in Bsep-/- mice is based on increased expression of the responsible canalicular transporter proteins.

  3. LKB1 (显示 STK11 ELISA试剂盒)/AMPK (显示 PRKAA1 ELISA试剂盒) and PKA control ABCB11 trafficking and polarization in hepatocytes.

  4. CA feeding of Bsep (-/-) mice increased hepatic Cyp3a11 protein levels.

  5. FXR (显示 NR1H4 ELISA试剂盒) regulates BSEP in an isoform-dependent and species-specific manner

  6. Ursodeoxycholic acid fed to abcb11-/- mice caused liver damage and the appearance of biliary tetra- and penta-hydroxy bile acids.

  7. Hepatic Abcb11 overexpression in mice increases the conservation of bile acids within the enterohepatic circulation.

  8. The authors show that two of these transporters, ABCB11 and ATP8B1 (显示 ATP8B1 ELISA试剂盒), are functional targets of miR (显示 MLXIP ELISA试剂盒)-33, a micro-RNA that is expressed from within an intron of SREBP-2 (显示 SREBF2 ELISA试剂盒).

  9. Abcb11 deficiency induces cholestasis coupled to impaired beta-fatty acid oxidation in mice.

  10. hyperosmotic cholestasis is triggered by a NADPH oxidase (显示 NOX1 ELISA试剂盒)-driven reactive oxygen species formation that mediates Fyn (显示 FYN ELISA试剂盒)-dependent retrieval of the Mrp2 (显示 ABCC2 ELISA试剂盒) and Bsep from the canalicular membrane, which may involve an increased cortactin (显示 CTTN ELISA试剂盒) phosphorylation.

ABCB11 抗原简介

Antigen Summary

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is the major canalicular bile salt export pump in man. Mutations in this gene cause a form of progressive familial intrahepatic cholestases which are a group of inherited disorders with severe cholestatic liver disease from early infancy.

Gene names and symbols associated with ABCB11

  • ATP binding cassette subfamily B member 11 (ABCB11) 抗体
  • bile salt export pump (LOC100489744) 抗体
  • bile salt export pump (LOC100565276) 抗体
  • bile salt export pump (EDI_111220) 抗体
  • bile salt export pump (EDI_272930) 抗体
  • bile salt export pump (abcb11) 抗体
  • ATP binding cassette subfamily B member 11 (Abcb11) 抗体
  • ATP-binding cassette, sub-family B (MDR/TAP), member 11 (Abcb11) 抗体
  • ABC16 抗体
  • ABCB11 抗体
  • BRIC2 抗体
  • BSEP 抗体
  • BSEP/SPGP 抗体
  • Lith1 抗体
  • PFIC-2 抗体
  • PFIC2 抗体
  • PGY4 抗体
  • Spgp 抗体

Protein level used designations for ABCB11

ATP-binding cassette, sub-family B (MDR/TAP), member 11 , bile salt export pump , bile salt export pump-like , ABC member 16, MDR/TAP subfamily , ATP-binding cassette sub-family B member 11 , progressive familial intrahepatic cholestasis 2 , sister p-glycoprotein , ATP-binding cassette, sub-family B, member 11 , sister of P-glycoprotein , liver bile salt export pump

GENE ID SPECIES
424170 Gallus gallus
470717 Pan troglodytes
488390 Canis lupus familiaris
531150 Bos taurus
100024107 Monodelphis domestica
100052359 Equus caballus
100083318 Ornithorhynchus anatinus
100404882 Callithrix jacchus
100454135 Pongo abelii
100473353 Ailuropoda melanoleuca
100489744 Xenopus (Silurana) tropicalis
100518154 Sus scrofa
100543935 Meleagris gallopavo
100565276 Anolis carolinensis
100590891 Nomascus leucogenys
5879080 Entamoeba dispar SAW760
5914265 Entamoeba dispar SAW760
100136688 Oncorhynchus mykiss
100337637 Cavia porcellus
8647 Homo sapiens
27413 Mus musculus
100008767 Oryctolagus cuniculus
83569 Rattus norvegicus
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