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The membrane-associated protein encoded by ABCA2 is a member of the superfamily of ATP-binding cassette (ABC) transporters. 再加上，我们可以发ABCA2 蛋白 (3)和数多这个蛋白质的别的产品。
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Human Polyclonal ABCA2 Primary Antibody for ELISA - ABIN451656
Macé, Cousin, Ricard, Génin, Spanakis, Lafargue-Soubigou, Génin, Fournel, Roche, Haussy, Massey, Soubigou, Bréfort, Benoit, Brice, Campion, Hollis, Pradier, Benavides, Deleuze: ABCA2 is a strong genetic risk factor for early-onset Alzheimer's disease. in Neurobiology of disease 2005
Our findings indicate a considerable and direct relationship between mRNA expression levels of ABCA2, ABCA3 (显示 ABCA3 抗体), MDR1 (显示 TBC1D9 抗体), and MRP1 (显示 MDM4 抗体) genes and positive minimal residual disease (MRD) measured after one year of treatment.
Down-regulation of the ATP-binding cassette transporter 2 (Abca2) reduces amyloid-beta production by altering Nicastrin (显示 NCSTN 抗体) maturation and intracellular localization.
SLC2A1/GLUT1 (显示 SLC2A1 抗体), SLC1A3/EAAT1 (显示 SLC1A3 抗体), and SLC1A2/EAAT2 (显示 SLC1A2 抗体) were the main SLC (显示 CCL21 抗体) proteins whereas ABCG2/BCRP (显示 ABCG2 抗体), ABCB1/MDR1 (显示 ABCB4 抗体), ABCA2 and ABCA8 (显示 ABCA8 抗体) were the main ABC (显示 ABCB6 抗体) quantified in isolated brain microvessels
A possible biochemical mechanism links ABCA2 expression, amyloid precursor protein (显示 APP 抗体) processing, and Alzheimer's disease.
we demonstrate that ABCA2-deficiency inhibits prostate tumor metastasis in vivo and decreases chemotactic potential of cells
roles for this largest known ABC (显示 ABCB6 抗体) protein in neural transmembrane lipid export
Reciprocal regulation of expression of the ABCA2 promoter by the early growth response-1 (显示 EGR1 抗体) and Sp-family transcription factors.
It is likely that expression of ABCA2 by two independent promoters constitutes locus of regulation controlling expression of the protein to meet requirements in different tissues.
Increased expression of ABCA2 may be causally linked with altered expression of genes associated with the pathogenesis of Alzheimer disease.
Among the 45 ABCA2 single nucleotide polymorphisms(SNPs) we tested, one synonymous SNP (rs908832) was found significantly associated with AD in both samples.
Study suggests that ABCA2 modulation of sphingolipid metabolism activates a signaling pathway that regulates amyloid precursor protein (显示 APP 抗体) transcription
control of ABCA2 expression level may be a key locus of regulation for esterification of plasma membrane-derived cholesterol through modulation of sphingolipid metabolism.
Data from knockout mice suggest that Abca2 functions in penile erection; Abca2 knockout mice are more susceptible to estrogen-induced convulsions than wildtype mice; Abca2 appears to be involved in biotransformation of therapeutic estrogens.
Lack of ABCA2 generates abnormalities in intracellular lipid distribution/trafficking in macrophages, increasing susceptibility to apoptosis in response to oxidized lipids and reduced atherosclerotic lesion development in LDL receptor (显示 LDLR 抗体) knockout mice.
The ATP-binding cassette transporter-2 (ABCA2) is a key regulator of cholesterol homeostasis and low-density lipoprotein receptor (显示 LDLR 抗体) metabolism in neuronal cells.
ABC-me (显示 ABCB10 抗体) is a novel gene that determines the ability to tolerate cardiac ischemia/reperfusion.
ABCA2 has a role in myelin compaction in spinal cord and cerebrum, and in phenotypic tremor
ABCA2 is expressed in non-myelin-forming as well as in myelin-forming Schwann cells. ABCA2 may be involved in transport of a substance associated with cellular maturation rather than initial myelin formation in both types of Schwann cells.
ABCA2 is involved in the intracellular metabolism of sphingolipids in the brain, particularly SM and gangliosides in oligodendrocytes and certain neurons.
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. This protein is highly expressed in brain tissue and may play a role in macrophage lipid metabolism and neural development. Two transcript variants encoding different isoforms have been found for this gene.
ATP-binding cassette 2
, ATP-binding cassette sub-family A member 2
, ATP-binding cassette transporter 2
, ATP-binding cassette, sub-family A, member 2
, ATP-binding cassette, sub-family A (ABC1), member 2
, ATP-binding cassette sub-family A member 2-like
, protein smg-8 homolog
, protein smg8
, smg-8 homolog, nonsense mediated mRNA decay factor