ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1B 蛋白 (ABCB1B)

The membrane-associated protein encoded by ABCB1B is a member of the superfamily of ATP-binding cassette (ABC) transporters. 再加上,我们可以发ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1B 抗体 (31)和数多这个蛋白质的别的产品。

列出全部蛋白 基因 基因ID UniProt
ABCB1B 5243 P08183
ABCB1B 18669 P06795
大鼠 ABCB1B ABCB1B 24646  
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ABCB1B 蛋白 by Origin and Source

Origin 在表达 标记
Human

Mouse (Murine) ,
,

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Human ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1B (ABCB1B) interaction partners

  1. we review the emerging role of molecular dynamics simulation techniques in our understanding of the membrane-embedded conformation of P-gp (显示 ABCB4 蛋白)--{REVIEW}

  2. Studied ABCB1 (显示 ABCB1 蛋白) protein expression immunohistochemically in twelve human post-mortem brain regions known to play a role in schizophrenia, in 13 patients with schizophrenia and nine controls; found a significantly reduced density of ABCB1 (显示 ABCB1 蛋白)-expressing neurons in the left habenula.

  3. Using an integrated pathway-based approach, we identified polymorphisms in ABCC6 (显示 ABCC6 蛋白), ABCB1 (显示 ABCB1 蛋白) and CYP2C8 (显示 CYP2C8 蛋白) associated with overall survival. These associations were replicated in a large independent cohort, highlighting the importance of pharmacokinetic genes as prognostic markers in Ewing sarcoma

  4. The authors found that transient TUBB3 (显示 TUBB3 蛋白) activation, through ABCB1 (显示 ABCB1 蛋白), in response to the stimulation of FOXO3a (显示 FOXO3 蛋白) expression, significantly contributes to the cross-resistance of the paclitaxel-resistant cell population and consequently limits the efficacy of both agents where cancer cells have developed multiple resistance.

  5. MDR1 and CYP3A5 (显示 CYP3A5 蛋白) genetic polymorphisms significantly influence plasma trough levels and therapeutic response of imatinib in patients with chronic myeloid leukemia (显示 BCL11A 蛋白). Patients with GG genotype for CYP3A5 (显示 CYP3A5 蛋白)-A6986G (P=0.016) and TT genotype for MDR1-C3435T (P=0.013) polymorphisms had significantly higher trough levels of imatinib.

  6. Rescue experiments confirmed the combined role of LUCAT1, miR (显示 MLXIP 蛋白)-200c and ABCB1 (显示 ABCB1 蛋白) on osteosarcoma proliferation, invasion and methotrexate resistance. Overall, results indicate the vital role of LUCAT1 in the methotrexate resistance regulation through miR (显示 MLXIP 蛋白)-200c/ABCB1 (显示 ABCB1 蛋白) pathway, providing a novel insight and treatment strategy for osteosarcoma drug resistance.

  7. Mdr1 enforces T Cell homeostasis in the presence of intestinal bile acids.

  8. Data show that co-treated with vincristine and XL019, a inhibitor of JAK2 and P-glycoprotein (P-gp), up-regulated expression of p21 and phosphorylated H2A histone family, member X (pH2AX).

  9. Tangeretin could sensitize ABCB1 (显示 ABCB1 蛋白)-overexpressing cancer cells to chemotherapeutical agents by directly inhibiting ABCB1 (显示 ABCB1 蛋白) transporter function.

  10. over-functional P-gp (显示 ABCB4 蛋白) might play an important role in the pathogenesis of ITP (显示 ITPA 蛋白) and induce GCs (显示 GCLC 蛋白) resistance in nonresponsive ITP (显示 ITPA 蛋白) patients. The blockage of P-gp (显示 ABCB4 蛋白) could be a promising therapeutic approach for GCs (显示 GCLC 蛋白)-resistant patients with ITP (显示 ITPA 蛋白).

Mouse (Murine) ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1B (ABCB1B) interaction partners

  1. conclusion, MDR1 (显示 ABCB4 蛋白) and BCRP are expressed on apical membranes of the rodent placental SynT (显示 STX1A 蛋白)-II layer.

  2. Mdr1 (显示 ABCB4 蛋白) enforces T Cell homeostasis in the presence of intestinal bile acids.

  3. Loss of ABCB1 (显示 ABCB1 蛋白) expression is associated with neonatal hyperbilirubinemia.

  4. the high-affinity site of P-glycoprotein is inaccessible because of either a conformational change or binding of detergent at the binding site in a detergent micelle environment; ligands bind to a low-affinity site, resulting in altered modulation of P-gp ATPase activity

  5. Data suggest that ATP binding to Abcb1b/P-glycoprotein (Pgp) in liposomes exhibits cooperativity with verapamil (a cardiovascular/antiarrhythmia drug); cooperativity between verapamil and a nonhydrolyzable ATP analog (AMPPNP) leads to distinct global conformational changes in Abcb1b/Pgp.

  6. Chrysosplenetin inhibited P-gp (显示 ABCB4 蛋白) activity and reverse the up-regulated P-gp (显示 ABCB4 蛋白) and MDR1 (显示 ABCB4 蛋白) levels induced by artemisinin.

  7. Tamsulosin and tolterodine with P-gp (显示 ABCB4 蛋白) gene expression and activity in an enantiomer-specific way.

  8. Pgp-coupled ATPase activity kinetics measured with a range of verapamil and digoxin concentrations fit well to a DDI model encompassing non-competitive and competitive inhibition of digoxin by verapamil.

  9. Data show that human transgenic mutant huntingtin (显示 HTT 蛋白) (mHtt) aggregation might be regulated by multidrug resistance protein 1 (MDR1 (显示 ABCB4 蛋白)) which suggests that MDR1 (显示 ABCB4 蛋白) might be a potential therapeutic target for Huntington's disease.

  10. In vitro and in vivo downregulation of the ATP binding cassette transporter (显示 ABCC3 蛋白) B1 by the HMG-CoA reductase (显示 HMGCR 蛋白) inhibitor simvastatin

蛋白简介ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1B (ABCB1B)

蛋白简介

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier.

Gene names and symbols associated with ABCB1B

  • ATP binding cassette subfamily B member 1 (ABCB1)
  • ATP-binding cassette, sub-family B (MDR/TAP), member 1B (Abcb1b)
  • ATP-binding cassette, subfamily B (MDR/TAP), member 1B (Abcb1b)
  • ABC20 蛋白
  • Abcb1 蛋白
  • CD243 蛋白
  • CLCS 蛋白
  • GP170 蛋白
  • mdr 蛋白
  • Mdr1 蛋白
  • Mdr1b 蛋白
  • P-GP 蛋白
  • Pgy-1 蛋白
  • Pgy1 蛋白

Protein level used designations for ABCB1B

P-glycoprotein 1 , colchicin sensitivity , doxorubicin resistance , multidrug resistance protein 1 , ATP-binding cassette sub-family B member 1 , P glycoprotein 1 , multidrug resistance protein 1B , ATP-binding cassette sub-family B (MDR/TAP) member 1 (P-glycoprotein/multidrug resistance 1) , ATP-binding cassette, sub-family B (MDR/TAP), member 1 (P-glycoprotein/multidrug resistance 1) , ATP-binding cassette, sub-family B (MDR/TAP), member 1B , ATP-binding cassette, subfamily B, member 1B , P-glycoprotein/multidrug resistance 1

GENE ID SPECIES
5243 Homo sapiens
18669 Mus musculus
24646 Rattus norvegicus
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