anti-ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1B (ABCB1B) 抗体

The membrane-associated protein encoded by ABCB1B is a member of the superfamily of ATP-binding cassette (ABC) transporters. 再加上,我们可以发ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1B 蛋白 (5)和数多这个蛋白质的别的产品。

列出全部抗体 基因 基因ID UniProt
ABCB1B 5243 P08183
ABCB1B 18669 P06795
ABCB1B 24646  
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产品编号 适用 宿主 标记 应用范围 图像 规格 供应商 交付 价格 详细
非结合性 FACS, IF (p), IHC (p) Formalin-fixed and paraffin embedded human lung carcinoma labeled with Anti-MDR1/p-GP/CD243 Polyclonal Antibody (ABIN670161), Unconjugated 1:200 at 1:200, followed by conjugation to the secondary antibody and DAB staining Formalin-fixed and paraffin embedded human lung carcinoma labeled with Anti-MDR1/p-GP/CD243 Polyclonal Antibody , Unconjugated 1:200 at 1:200, followed by conjugation to the secondary antibody and DAB staining 100 μL Log in to see 3至7个工作日
$318.45
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非结合性 ICC, IF, IHC (p) Immunofluorescence analysis of mouse kidney tissue using anti-MDR1 (dilution of primary antibody - 1:1000) Immunohistochemical staining of paraffin embedded mouse kidney tissue using anti-MDR1 (primary antibody at 1:1000) 100 μg Log in to see 11至16个工作日
$438.96
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小鼠 非结合性 IF, IP, WB   100 μL Log in to see 16 Days
$405.08
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小鼠 非结合性 IC, FACS, IHC, WB   250 μg Log in to see 11至16个工作日
$771.57
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大鼠 非结合性 IC, FACS, IHC, WB   125 μg Log in to see 11至16个工作日
$795.14
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小鼠 非结合性 IC, FACS, IHC, WB   125 μg Log in to see 11至16个工作日
$807.71
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小鼠 非结合性 WB   100 μL Log in to see 11至16个工作日
$570.43
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小鼠 非结合性 IC, FACS, IP, IHC, WB   100 μg Log in to see 11至16个工作日
$672.57
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小鼠 非结合性 IC, FACS, IP   1 mL Log in to see 11至16个工作日
$707.14
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小鼠 非结合性 FACS, IF, IHC, WB   500 μL Log in to see 11至16个工作日
$650.57
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通过反应活性、应用领域、克隆类型和共轭标记 ABCB1B 抗体

特性 应用范围 宿主 克隆类型 标记
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引用最多的anti-ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1B 抗体

  1. Human Polyclonal ABCB1B Primary Antibody for FACS, IF (p) - ABIN670161 : Hu, Peng, Li: The expression and significance of P-glycoprotein, lung resistance protein and multidrug resistance-associated protein in gastric cancer. in Journal of experimental & clinical cancer research : CR 2009 (PubMed)
    Show all 2 Pubmed References

更多抗ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1B的相互作用对抗体

Human ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1B (ABCB1B) interaction partners

  1. Results show that CD133 and MDR1 (显示 TBC1D9 抗体) expression increase in recurrent pediatric pilocytic astrocytomas (PAs (显示 PASK 抗体)) following chemotherapy, and in drug resistant tumor cells. CD133 regulates MDR1 (显示 TBC1D9 抗体) expression via the PI3K (显示 PIK3CA 抗体)/AKT (显示 AKT1 抗体)/NF-kappaB (显示 NFKB1 抗体) signaling. These results provide evidence that CD133 contributes to multidrug resistance by regulating MDR1 (显示 TBC1D9 抗体) levels via the PI3K (显示 PIK3CA 抗体)-Akt (显示 AKT1 抗体)-NF-kappaB (显示 NFKB1 抗体) signal pathway.

  2. PG accumulation assay is a new, unique tool for the parallel determination of the function of the ABCG2 (显示 ABCG2 抗体), ABCB1 (显示 ABCB1 抗体), and ABCC1 (显示 ABCC1 抗体) multidrug transporters

  3. Abcb1a (显示 ABCB1 抗体)/b(-/-);Abcg2 (显示 ABCG2 抗体)(-/-) mice revealed increased brain penetration of rapamycin (13-fold), AZD8055 (7.7-fold), and NVP-BEZ235 (4.5-fold), but not ZSTK474 relative to WT mice. Importantly, ABC (显示 ABCB6 抗体) transporters limited rapamycin brain penetration to subtherapeutic levels, while the reduction in NVP-BEZ235 brain penetration did not prevent target inhibition.

  4. ABCB1 (显示 ABCB1 抗体) genotype is not a significant determinant of interindividual variability in dabigatran and rivaroxaban pharmacokinetics

  5. High MDR1 (显示 TBC1D9 抗体) expression is associated with multidrug resistance in breast cancer.

  6. inhibition of autophagy led to the decrease in stemness, restoration of mitochondrial proteins and reduced expression of CD44 (显示 CD44 抗体), ABCB1 (显示 ABCB1 抗体) and ADAM17 (显示 ADAM17 抗体)

  7. The T-allele of ABCB1 (显示 ABCB1 抗体)-C3435T gene polymorphism has demonstrated to be a good prognosis factor for resistance, progression free survival and overall survival in HER2 (显示 ERBB2 抗体)-positive Breast Cancer patients.

  8. we review the emerging role of molecular dynamics simulation techniques in our understanding of the membrane-embedded conformation of P-gp (显示 ABCB4 抗体)--{REVIEW}

  9. Studied ABCB1 (显示 ABCB1 抗体) protein expression immunohistochemically in twelve human post-mortem brain regions known to play a role in schizophrenia, in 13 patients with schizophrenia and nine controls; found a significantly reduced density of ABCB1 (显示 ABCB1 抗体)-expressing neurons in the left habenula.

  10. Using an integrated pathway-based approach, we identified polymorphisms in ABCC6 (显示 ABCC6 抗体), ABCB1 (显示 ABCB1 抗体) and CYP2C8 (显示 CYP2C8 抗体) associated with overall survival. These associations were replicated in a large independent cohort, highlighting the importance of pharmacokinetic genes as prognostic markers in Ewing sarcoma

Mouse (Murine) ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1B (ABCB1B) interaction partners

  1. Molecular Dynamics simulations and docking of drugs performed for P-gp (P-gp (显示 ABCB4 抗体), multi-drug resistance protein, MDR1 (显示 ABCB4 抗体)).Drugs with ER < 1 (显示 MIER1 抗体) almost do not bind the main binding cavity (MBC (显示 CACNA1C 抗体)) of P-gp (显示 ABCB4 抗体).

  2. conclusion, MDR1 (显示 ABCB4 抗体) and BCRP (显示 ABCG2 抗体) are expressed on apical membranes of the rodent placental SynT (显示 STX1A 抗体)-II layer.

  3. Mdr1 (显示 ABCB4 抗体) enforces T Cell homeostasis in the presence of intestinal bile acids.

  4. Loss of ABCB1 (显示 ABCB1 抗体) expression is associated with neonatal hyperbilirubinemia.

  5. the high-affinity site of P-glycoprotein is inaccessible because of either a conformational change or binding of detergent at the binding site in a detergent micelle environment; ligands bind to a low-affinity site, resulting in altered modulation of P-gp (显示 ABCB4 抗体) ATPase (显示 DNAH8 抗体) activity

  6. Data suggest that ATP binding to Abcb1b/P-glycoprotein (Pgp) in liposomes exhibits cooperativity with verapamil (a cardiovascular/antiarrhythmia drug); cooperativity between verapamil and a nonhydrolyzable ATP analog (AMPPNP) leads to distinct global conformational changes in Abcb1b/Pgp.

  7. Chrysosplenetin inhibited P-gp (显示 ABCB4 抗体) activity and reverse the up-regulated P-gp (显示 ABCB4 抗体) and MDR1 (显示 ABCB4 抗体) levels induced by artemisinin.

  8. Tamsulosin and tolterodine with P-gp (显示 ABCB4 抗体) gene expression and activity in an enantiomer-specific way.

  9. Pgp (显示 ABCB4 抗体)-coupled ATPase (显示 DNAH8 抗体) activity kinetics measured with a range of verapamil and digoxin concentrations fit well to a DDI model encompassing non-competitive and competitive inhibition of digoxin by verapamil.

  10. Data show that human transgenic mutant huntingtin (显示 HTT 抗体) (mHtt) aggregation might be regulated by multidrug resistance protein 1 (MDR1 (显示 ABCB4 抗体)) which suggests that MDR1 (显示 ABCB4 抗体) might be a potential therapeutic target for Huntington's disease.

ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1B (ABCB1B) 抗原简介

蛋白简介

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier.

Gene names and symbols associated with ABCB1B

  • ATP binding cassette subfamily B member 1 (ABCB1) 抗体
  • ATP-binding cassette, sub-family B (MDR/TAP), member 1B (Abcb1b) 抗体
  • ATP-binding cassette, subfamily B (MDR/TAP), member 1B (Abcb1b) 抗体
  • ABC20 抗体
  • Abcb1 抗体
  • CD243 抗体
  • CLCS 抗体
  • GP170 抗体
  • mdr 抗体
  • Mdr1 抗体
  • Mdr1b 抗体
  • P-GP 抗体
  • Pgy-1 抗体
  • Pgy1 抗体

Protein level used designations for ABCB1B

P-glycoprotein 1 , colchicin sensitivity , doxorubicin resistance , multidrug resistance protein 1 , ATP-binding cassette sub-family B member 1 , P glycoprotein 1 , multidrug resistance protein 1B , ATP-binding cassette sub-family B (MDR/TAP) member 1 (P-glycoprotein/multidrug resistance 1) , ATP-binding cassette, sub-family B (MDR/TAP), member 1 (P-glycoprotein/multidrug resistance 1) , ATP-binding cassette, sub-family B (MDR/TAP), member 1B , ATP-binding cassette, subfamily B, member 1B , P-glycoprotein/multidrug resistance 1

GENE ID SPECIES
5243 Homo sapiens
18669 Mus musculus
24646 Rattus norvegicus
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