anti-ADAM Metallopeptidase with thrombospondin Type 1 Motif, 5 (ADAMTS5) 抗体

ADAMTS5 encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. 再加上,我们可以发ADAMTS5 试剂盒 (39)ADAMTS5 蛋白 (9)和数多这个蛋白质的别的产品。

列出全部抗体 基因 基因ID UniProt
ADAMTS5 23794 Q9R001
ADAMTS5 11096 Q9UNA0
ADAMTS5 304135  
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Showing 10 out of 122 products:

产品编号 适用 宿主 标记 应用范围 图像 规格 供应商 交付 价格 详细
非结合性 EIA, WB Western blot analysis of anti-ADAMTS5 Antibody (Center) in mouse muscle tissue lysates (35ug/lane). ADAMTS5(arrow) was detected using the purified Pab. 0.4 mL Log in to see 6至8个工作日
$390.50
详细
小鼠 非结合性 WB Western blot analysis of anti-ADAMTS5 Antibody (Center) (ABIN391652) in mouse muscle tissue lysates (35 µg/lane). ADAMTS5(arrow) was detected using the purified polyclonal antibody. 400 μL Log in to see 10至11个工作日
$324.50
详细
Bat 非结合性 IHC (p) Anti-ADAMTS5 antibody  ABIN1048295 IHC staining of human cartilage. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. 50 μg Log in to see 7至9个工作日
$451.00
详细
非结合性 WB   100 μg Log in to see 4至6个工作日
$240.00
详细
非结合性 IHC (p), WB Anti-ADAMTS5 antibody, IHC(P) IHC(P): Rat Brain Tissue 100 μg Log in to see 4至6个工作日
$200.00
详细
非结合性 IF (p), IHC (p) Formalin-fixed and paraffin embedded mouse heart labeled with Rabbit Anti Aggrecanase-2/ADAMTS5 Polyclonal Antibody, Unconjugated (ABIN701005) at 1:200 followed by conjugation to the secondary antibody and DAB staining Formalin-fixed and paraffin embedded rat brain labeled with Rabbit Anti Aggrecanase-2/ADAMTS5 Polyclonal Antibody, Unconjugated (ABIN701005) at 1:200 followed by conjugation to the secondary antibody and DAB staining 100 μL Log in to see 3至7个工作日
$295.90
详细
非结合性 WB ADAMTS5 Antibody (N-term) (ABIN657768) western blot analysis in K562 cell line lysates (35 µg/lane). This demonstrates the ADAMTS5 antibody detected the ADAMTS5 protein (arrow). 400 μL Log in to see 10至11个工作日
$324.50
详细
非结合性 IHC (p), WB IHC-P Image Immunohistochemical analysis of paraffin-embedded A549 xenograft, using ADAMTS5, antibody at 1:100 dilution. WB Image Sample (30 ug of whole cell lysate) A: JC 7.5% SDS PAGE antibody diluted at 1:1000 100 μL Log in to see 1至2个工作日
$358.60
详细
非结合性 ICC, IHC, IP, WB 100 μg Log in to see 13至16个工作日
$350.00
详细
非结合性 IHC, IHC (p), WB Immunohistochemistry-Paraffin: ADAMTS5 Antibody [NBP2-15286] - Paraffin-embedded Hepatoma, using antibody at 1:500 dilution. Western Blot: ADAMTS5 Antibody [NBP2-15286] - Sample (30 ug of whole cell lysate) A: HeLa B: HepG2 7. 5% SDS PAGE, antibody diluted at 1:3000. 0.1 mL Log in to see 8至11个工作日
$447.56
详细

通过反应活性、应用领域、克隆类型和共轭标记 ADAMTS5 抗体

特性 应用范围 宿主 克隆类型 标记
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更多抗ADAMTS5的相互作用对抗体

Mouse (Murine) ADAM Metallopeptidase with thrombospondin Type 1 Motif, 5 (ADAMTS5) interaction partners

  1. Adamts5(-/-) mice were protected from hepatic mitochondrial dysfunction, as indicated by increased mitochondrial respiratory chain complex activity, higher ATP levels and higher expression of antioxidant enzymes. Absence of ADAMTS5 preserves liver integrity in a diet-induced obesity model.

  2. research emphasises the importance of ADAMTS5 expression in the control of influenza virus infection and highlights the potential for development of ADAMTS5-based therapeutic strategies to reduce morbidity and mortality

  3. TS5 protein functions to suppress glucose uptake in adipose-derived stromal cells and thereby inhibits the synthesis, and promotes the intracellular degradation of Acan (显示 ACAN 抗体) and Vcan (显示 Vcan 抗体) by an ADAMTS (显示 ADAMTS1 抗体) other than TS5.

  4. Data suggest that ADAMTS-5 oligomerization is required for full aggrecanase (显示 ADAMTS4 抗体) activity in vitro and in situ (as seen in knee joint of mouse model of inflammatory arthritis); thus, blocking oligomerization inhibits ADAMTS-5 activity.

  5. aggrecan (显示 ACAN 抗体) and brevican (显示 BCAN 抗体) proteolysis is compensated in Adamts4 (显示 ADAMTS4 抗体)-/- or Adamts5-/- mice by ADAMTS (显示 ADAMTS1 抗体) proteoglycanase (显示 MMP3 抗体) family members but a threshold of versican (显示 Vcan 抗体) proteolysis is sensitive to the loss of a single ADAMTS (显示 ADAMTS1 抗体) proteoglycanase (显示 MMP3 抗体) during spinal cord injury

  6. The present study reveals ADAMT-5 expression by mast cells(MCs (显示 SMCP 抗体)) and that MC activation regulates the expression of the protease, thus implicating the ADAMT-5 of protease in MC function.

  7. Western blot analyses indicated that aggrecanase (显示 ADAMTS4 抗体)-generated proteoglycan (显示 Vcan 抗体) fragments are produced after SCI.

  8. RelA/p65 (显示 NFkBP65 抗体) is a potent transcriptional activator of ADAMTS5 in chondrocytes during osteoarthritis development.

  9. Repair of biomechanically compromised tendons exhibiting midsubstance chondroid accumulation requires ADAMTS5.

  10. this study identified, for the first time, several genes that have an ADAMTS-5-independent role in osteoarthritis(OA), identifying them as possible OA initiation candidates.

Human ADAM Metallopeptidase with thrombospondin Type 1 Motif, 5 (ADAMTS5) interaction partners

  1. The findings suggest that miR (显示 MLXIP 抗体)-140 suppresses colorectal cancer progression and metastasis, possibly through downregulating ADAMTS5 and IGFBP5 (显示 IGFBP5 抗体).

  2. Results provide direct evidence indicating that Fibulin-2 (显示 FBLN2 抗体) is a novel substrate of ADAMTS-5 and that this proteolysis could alter the cellular microenvironment affecting the balance between protumor and antitumor effects associated to both Fibulin-2 (显示 FBLN2 抗体) and the ADAMTSs metalloproteases.

  3. Endoplasmic reticulum stress participates in the progress of senescence and apoptosis of osteoarthritic chondrocytes, which manifested in increased expression of ADAMTS5, MMP13 (显示 MMP13 抗体), and decreased COL2A1 (显示 COL2A1 抗体) expression.

  4. Single Nucleotide Variants of Candidate Genes in Aggrecan (显示 ACAN 抗体) Metabolic Pathway Are Associated with Lumbar Disc Degeneration and Modic Changes

  5. RREB1 (显示 RREB1 抗体) cooperates with noncoding RNA linc-ADAMTS5 to inhibit ADAMTS5 expression, thereby affecting degeneration of the extracellular matrix (ECM (显示 MMRN1 抗体)) of the intervertebral disc.

  6. Matrilin 2 (显示 MATN2 抗体) accumulation associated with relative ADAMTS5 deficiency may contribute to the mechanism underlying calcific aortic valve disease progression.

  7. In osteoarthritis (OA) chondrocytes, hydrostatic pressure (HP) restores the expression levels of some miRNAs, downregulates MMP-13 (显示 MMP13 抗体), ADAMTS-5, and HDAC-4 (显示 HDAC4 抗体), and modulates the Wnt (显示 WNT2 抗体)/beta-catenin (显示 CTNNB1 抗体) pathway activation.

  8. we investigated whether important polymorphisms in the ADAMTS4 (显示 ADAMTS4 抗体) and ADAMTS5 genes affect osteoarthritis (OA) susceptibility. ADAMTS4 (显示 ADAMTS4 抗体) and ADAMTS5 genotypes were determined using the ABI Prism StepOnePlus Real-Time system. Our findings suggest that the ADAMTS4 (显示 ADAMTS4 抗体) (rs4233367 and rs11807350) and ADAMTS5 (rs226794 and rs2830585) variants examined may not contribute to susceptibility to knee OA in the Turkish population.

  9. Increased ADAMTS5 levels were observed in placental insufficiency cases.

  10. ADAMTS5 protein levels in semen were significantly lower in males with infertility. Sperm count and motility showed a negative correlation with levels of ADAMTS5 protein expression.

Cow (Bovine) ADAM Metallopeptidase with thrombospondin Type 1 Motif, 5 (ADAMTS5) interaction partners

  1. The delayed activation of proMMPs and the relatively low cleavage efficiency of MMPs compared to ADAMTS5 (aggrecanase (显示 ADAMTS4 抗体)) explains the minor contribution of the MMP enzymes to aggrecan (显示 ACAN 抗体) catabolism in vivo.

  2. ADAMTS4 (显示 ADAMTS4 抗体) and ADAMTS5 are inhibited by alpha2-macroglobulin (显示 A2M 抗体)

  3. identified multiple conserved amino acids within regions N- and C-terminal to the site of scission that may influence enzyme-substrate recognition, and may interact with exosites on ADAMTS-4 (显示 ADAMTS4 抗体) and ADAMTS-5

  4. Co-culture of mechanically injured cartilage with joint capsule tissue alters chondrocyte expression patterns and increases ADAMTS5 production.

ADAMTS5 抗原简介

蛋白简介

This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme encoded by this gene contains two C-terminal TS motifs and functions as aggrecanase to cleave aggrecan, a major proteoglycan of cartilage.

Gene names and symbols associated with ADAMTS5

  • ADAM metallopeptidase with thrombospondin type 1 motif 5 (ADAMTS5) 抗体
  • ADAM metallopeptidase with thrombospondin type 1 motif 5 (adamts5) 抗体
  • a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 5 (aggrecanase-2) (Adamts5) 抗体
  • ADAM metallopeptidase with thrombospondin type 1 motif, 5 (Adamts5) 抗体
  • 9530092O11Rik 抗体
  • ADAM-TS5 抗体
  • ADAM-TS 5 抗体
  • ADAM-TS 11 抗体
  • ADAMTS-5 抗体
  • ADAMTS-11 抗体
  • ADAMTS1 抗体
  • ADAMTS11 抗体
  • ADMP-2 抗体
  • AI481094 抗体
  • ASMP-2 抗体

Protein level used designations for ADAMTS5

ADAM metallopeptidase with thrombospondin type 1 motif, 5 , a disintegrin and metalloproteinase with thrombospondin motifs 5-like , A disintegrin and metalloproteinase with thrombospondin motifs 5 , ADAM-TS 5 , ADAMTS-5 , ADMP-2 , aggrecanase-2 , implantin , a disintegrin and metalloproteinase with thrombospondin motifs 11 , a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 5 (aggrecanase-2) , ADAM-TS5 , a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 5 , a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 5 (aggrecanase-2)

GENE ID SPECIES
100091913 Ornithorhynchus anatinus
100441162 Pongo abelii
100488158 Xenopus (Silurana) tropicalis
100552915 Anolis carolinensis
23794 Mus musculus
11096 Homo sapiens
100522952 Sus scrofa
286805 Bos taurus
304135 Rattus norvegicus
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