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ADAMTS4 encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. 再加上，我们可以发ADAM Metallopeptidase with Thrombospondin Type 1 Motif, 4 抗体 (167) 和 ADAM Metallopeptidase with Thrombospondin Type 1 Motif, 4 蛋白 (9)和数多这个蛋白质的别的产品。
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Human ADAMTS4 ELISA Kit for Sandwich ELISA - ABIN649162
Zha, Chen, Xu, Zhang, Li, Zhao, Cui: Elevated level of ADAMTS4 in plasma and peripheral monocytes from patients with acute coronary syndrome. in Clinical research in cardiology : official journal of the German Cardiac Society 2010
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Moncada-Pazos, Obaya, Viloria, López-Otín, Cal: The nutraceutical flavonoid luteolin inhibits ADAMTS-4 and ADAMTS-5 aggrecanase activities. in Journal of molecular medicine (Berlin, Germany) 2011
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the reduction of ADAMTS-4 activity during the progression of ALS pathology may be an adaptive change to mitigate its neurodegenerative impact in CNS tissues
Results show that ADAMTS15 (显示 ADAMTS15 ELISA试剂盒) and ADAMTS4 not only exhibit unique cellular expression patterns in the brain but their developmental upregulation by these cell types coincides with critical aspects of neural development
aggrecan (显示 ACAN ELISA试剂盒) and brevican (显示 BCAN ELISA试剂盒) proteolysis is compensated in Adamts4-/- or Adamts5 (显示 ADAMTS5 ELISA试剂盒)-/- mice by ADAMTS (显示 ADAMTS1 ELISA试剂盒) proteoglycanase (显示 MMP3 ELISA试剂盒) family members but a threshold of versican (显示 Vcan ELISA试剂盒) proteolysis is sensitive to the loss of a single ADAMTS (显示 ADAMTS1 ELISA试剂盒) proteoglycanase (显示 MMP3 ELISA试剂盒) during spinal cord injury
ADAMTS4 has roles in melanoma growth and angiogenesis in mice
The serine protease (显示 F2 ELISA试剂盒) tissue plasminogen activator (tPA (显示 PLAT ELISA试剂盒)) and two matrix metalloproteinases, ADAMTS-4 and ADAMTS-5 (显示 ADAMTS5 ELISA试剂盒), were identified as Reelin (显示 RELN ELISA试剂盒) cleaving enzymes.
ADAMTS-4 cleaves Reelin (显示 RELN ELISA试剂盒) in an isoform-specific manner. Among ADAMTS-4 isoforms, p50 (显示 LSP1 ELISA试剂盒) cleaves the N-t site only, while p75 (显示 NGFR ELISA试剂盒) cleaves both sites.
Data demonstrate that Adamts1 (显示 ADAMTS1 ELISA试剂盒) and Adamts4 play redundant and essential roles in perinatal kidney development.
Drastic down-regulation of Adamts4 observed at both E16 (显示 SLC7A5 ELISA试剂盒) and E18; RT-PCR revealed post-natal reduction in expression (Adamts4, 1/3). Results suggest down-regulation of gene is important factor in normal odontogenesis in dental papillae.
proteolysis of hevin by ADAMTS4 in the mouse cerebellum is important for the normal development of this tissue
ADAMTS1 (显示 ADAMTS1 ELISA试剂盒), ADAMTS4, and ADAMTS5 (显示 ADAMTS5 ELISA试剂盒) are expressed in patterns that relate to the expression pattern of versican (显示 Vcan ELISA试剂盒) in granulosa cells of small follicles, expanded cumulus cell-oocyte complexes, and endothelial cells of the ovary.
Using in vitro approaches and cultured breast cancer cell lines authors demonstrate that Fibulin-2 (显示 FBLN2 ELISA试剂盒) is a better substrate for ADAMTS-5 (显示 ADAMTS5 ELISA试剂盒) than it is for ADAMTS-4. Fibulin-2 (显示 FBLN2 ELISA试剂盒) degradation is associated to an enhancement of the invasive potential of T47D, MCF-7 and SK-BR-3 cells.
ADAMTS4 and ADAMTS15 (显示 ADAMTS15 ELISA试剂盒) were upregulated in symptomatic uterine leiomyomas.
The SNP rs4233367 in the exon of ADAMTS-4 gene may be associated with lumbar disc degeneration.
Single Nucleotide Variants of Candidate Genes in Aggrecan (显示 ACAN ELISA试剂盒) Metabolic Pathway Are Associated with Lumbar Disc Degeneration and Modic Changes
Results show that ADAMTS4 mRNA is the target of mir (显示 MLXIP ELISA试剂盒)-1268a and its expression might be modified by MIR (显示 MLXIP ELISA试剂盒)-1268a rs28599926 polymorphism in hepatocellular carcinoma.
we investigated whether important polymorphisms in the ADAMTS4 and ADAMTS5 (显示 ADAMTS5 ELISA试剂盒) genes affect osteoarthritis (OA) susceptibility. ADAMTS4 and ADAMTS5 (显示 ADAMTS5 ELISA试剂盒) genotypes were determined using the ABI Prism StepOnePlus Real-Time system. Our findings suggest that the ADAMTS4 (rs4233367 and rs11807350) and ADAMTS5 (显示 ADAMTS5 ELISA试剂盒) (rs226794 and rs2830585) variants examined may not contribute to susceptibility to knee OA in the Turkish population.
ADAMTS4 expression is significantly upregulated in human masticatory mucosa during wound healing
ADAMTS4 may have a role in the pathogenesis by causing increased oxidative and inflammatory environment in preterm premature rupture of membranes .
in degenerative intervertebral discs, IL1b (显示 IL1B ELISA试剂盒) upregulates NFkB, MMP13 (显示 MMP13 ELISA试剂盒) and ADAMTS4
progesterone acts via the progesterone receptor (显示 PGR ELISA试剂盒) to modulate ADAMTS 1 (显示 ADAMTS1 ELISA试剂盒) and 4 levels in ovarian cancer cell lines.
ADAMTS4 participates in the regulation of muscle development in cattle.
aggrecanase activity (a) is responsible for early TNFalpha (显示 TNF ELISA试剂盒)-dependent aggrecan (显示 ACAN ELISA试剂盒) cleavage and GAG release in the meniscus and (b) might be involved in meniscal degeneration.
ADAMTS4 and ADAMTS5 (显示 ADAMTS5 ELISA试剂盒) are inhibited by alpha2-macroglobulin (显示 A2M ELISA试剂盒)
identified multiple conserved amino acids within regions N- and C-terminal to the site of scission that may influence enzyme-substrate recognition, and may interact with exosites on ADAMTS-4 and ADAMTS-5 (显示 ADAMTS5 ELISA试剂盒)
This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme encoded by this gene lacks a C-terminal TS motif. It is responsible for the degradation of aggrecan, a major proteoglycan of cartilage, and brevican, a brain-specific extracellular matrix protein. The cleavage of aggrecan and brevican suggests key roles of this enzyme in arthritic disease and in the central nervous system, potentially, in the progression of glioma.
A disintegrin and metalloproteinase with thrombospondin motifs 4
, ADAM-TS 4
, a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 4
, a disintegrin and metallopeptidase with thrombospondin motifs 4
, a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 4
, ADAM metallopeptidase with thrombospondin type 1 motif, 4
, A disintegrin and metalloproteinase with thrombospondin motifs 4-like
, disintegrin and metalloproteinase with thrombospondin motifs 2
, a disintegrin and metalloproteinase with thrombospondin motifs 4