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ADAMTS4 encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. 再加上，我们可以发ADAM Metallopeptidase with Thrombospondin Type 1 Motif, 4 试剂盒 (42) 和 ADAM Metallopeptidase with Thrombospondin Type 1 Motif, 4 蛋白 (9)和数多这个蛋白质的别的产品。
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Cow (Bovine) Polyclonal ADAMTS4 Primary Antibody for IHC, WB - ABIN2776877
Lee, Hwang, Park, Lee, Park, Kang, Lee, Kim, Park, Park: Comparison of ADAMTS-1, -4 and -5 expression in culprit plaques between acute myocardial infarction and stable angina. in Journal of clinical pathology 2011
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Human Polyclonal ADAMTS4 Primary Antibody for WB - ABIN391642
Tortorella, Pratta, Liu, Abbaszade, Ross, Burn, Arner: The thrombospondin motif of aggrecanase-1 (ADAMTS-4) is critical for aggrecan substrate recognition and cleavage. in The Journal of biological chemistry 2000
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the reduction of ADAMTS-4 activity during the progression of ALS pathology may be an adaptive change to mitigate its neurodegenerative impact in CNS tissues
Results show that ADAMTS15 (显示 ADAMTS15 抗体) and ADAMTS4 not only exhibit unique cellular expression patterns in the brain but their developmental upregulation by these cell types coincides with critical aspects of neural development
aggrecan (显示 ACAN 抗体) and brevican (显示 BCAN 抗体) proteolysis is compensated in Adamts4-/- or Adamts5 (显示 ADAMTS5 抗体)-/- mice by ADAMTS (显示 ADAMTS1 抗体) proteoglycanase (显示 MMP3 抗体) family members but a threshold of versican (显示 Vcan 抗体) proteolysis is sensitive to the loss of a single ADAMTS (显示 ADAMTS1 抗体) proteoglycanase (显示 MMP3 抗体) during spinal cord injury
ADAMTS4 has roles in melanoma growth and angiogenesis in mice
The serine protease (显示 F2 抗体) tissue plasminogen activator (tPA (显示 PLAT 抗体)) and two matrix metalloproteinases, ADAMTS-4 and ADAMTS-5 (显示 ADAMTS5 抗体), were identified as Reelin (显示 RELN 抗体) cleaving enzymes.
ADAMTS-4 cleaves Reelin (显示 RELN 抗体) in an isoform-specific manner. Among ADAMTS-4 isoforms, p50 (显示 LSP1 抗体) cleaves the N-t site only, while p75 (显示 NGFR 抗体) cleaves both sites.
Data demonstrate that Adamts1 (显示 ADAMTS1 抗体) and Adamts4 play redundant and essential roles in perinatal kidney development.
Drastic down-regulation of Adamts4 observed at both E16 (显示 SLC7A5 抗体) and E18; RT-PCR revealed post-natal reduction in expression (Adamts4, 1/3). Results suggest down-regulation of gene is important factor in normal odontogenesis in dental papillae.
proteolysis of hevin by ADAMTS4 in the mouse cerebellum is important for the normal development of this tissue
ADAMTS1 (显示 ADAMTS1 抗体), ADAMTS4, and ADAMTS5 (显示 ADAMTS5 抗体) are expressed in patterns that relate to the expression pattern of versican (显示 Vcan 抗体) in granulosa cells of small follicles, expanded cumulus cell-oocyte complexes, and endothelial cells of the ovary.
Using in vitro approaches and cultured breast cancer cell lines authors demonstrate that Fibulin-2 (显示 FBLN2 抗体) is a better substrate for ADAMTS-5 (显示 ADAMTS5 抗体) than it is for ADAMTS-4. Fibulin-2 (显示 FBLN2 抗体) degradation is associated to an enhancement of the invasive potential of T47D, MCF-7 and SK-BR-3 cells.
ADAMTS4 and ADAMTS15 (显示 ADAMTS15 抗体) were upregulated in symptomatic uterine leiomyomas.
The SNP rs4233367 in the exon of ADAMTS-4 gene may be associated with lumbar disc degeneration.
Single Nucleotide Variants of Candidate Genes in Aggrecan (显示 ACAN 抗体) Metabolic Pathway Are Associated with Lumbar Disc Degeneration and Modic Changes
Results show that ADAMTS4 mRNA is the target of mir (显示 MLXIP 抗体)-1268a and its expression might be modified by MIR (显示 MLXIP 抗体)-1268a rs28599926 polymorphism in hepatocellular carcinoma.
The pregnancy loss rate seems to be affected by both ADAMTS-3 and ADAMTS-16 (显示 ADAMTS16 抗体).
we investigated whether important polymorphisms in the ADAMTS4 and ADAMTS5 (显示 ADAMTS5 抗体) genes affect osteoarthritis (OA) susceptibility. ADAMTS4 and ADAMTS5 (显示 ADAMTS5 抗体) genotypes were determined using the ABI Prism StepOnePlus Real-Time system. Our findings suggest that the ADAMTS4 (rs4233367 and rs11807350) and ADAMTS5 (显示 ADAMTS5 抗体) (rs226794 and rs2830585) variants examined may not contribute to susceptibility to knee OA in the Turkish population.
ADAMTS4 expression is significantly upregulated in human masticatory mucosa during wound healing
ADAMTS4 may have a role in the pathogenesis by causing increased oxidative and inflammatory environment in preterm premature rupture of membranes .
in degenerative intervertebral discs, IL1b (显示 IL1B 抗体) upregulates NFkB, MMP13 (显示 MMP13 抗体) and ADAMTS4
Studies suggest that miR (显示 MYLIP 抗体)-140 is an important regulator of cartilage development and homeostasis in cord blood-derived mesenchymal stromal cells (eCB-MSCs) that may act, in part, through the regulation of CXCL12 (显示 CXCL12 抗体) and ADAMTS-5 (显示 ADAMTS5 抗体).
ADAMTS5 (显示 ADAMTS5 抗体) is present in degenerative suspensory ligament desmitis as a high molecular weight complex
a single injection of ADAMTS5 (显示 ADAMTS5 抗体) siRNA induced the suppression of degradation in rabbit nucleus pulposus tissues
ADAMTS4 participates in the regulation of muscle development in cattle.
aggrecanase activity (a) is responsible for early TNFalpha (显示 TNF 抗体)-dependent aggrecan (显示 ACAN 抗体) cleavage and GAG release in the meniscus and (b) might be involved in meniscal degeneration.
ADAMTS4 and ADAMTS5 (显示 ADAMTS5 抗体) are inhibited by alpha2-macroglobulin (显示 A2M 抗体)
identified multiple conserved amino acids within regions N- and C-terminal to the site of scission that may influence enzyme-substrate recognition, and may interact with exosites on ADAMTS-4 and ADAMTS-5 (显示 ADAMTS5 抗体)
This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme encoded by this gene lacks a C-terminal TS motif. It is responsible for the degradation of aggrecan, a major proteoglycan of cartilage, and brevican, a brain-specific extracellular matrix protein. The cleavage of aggrecan and brevican suggests key roles of this enzyme in arthritic disease and in the central nervous system, potentially, in the progression of glioma.
A disintegrin and metalloproteinase with thrombospondin motifs 4
, ADAM-TS 4
, a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 4
, a disintegrin and metallopeptidase with thrombospondin motifs 4
, a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 4
, ADAM metallopeptidase with thrombospondin type 1 motif, 4
, A disintegrin and metalloproteinase with thrombospondin motifs 4-like
, disintegrin and metalloproteinase with thrombospondin motifs 2
, a disintegrin and metalloproteinase with thrombospondin motifs 4