5'-Nucleotidase, Cytosolic II 蛋白 (NT5C2)

NT5C2 encodes a hydrolase that serves as an important role in cellular purine metabolism by acting primarily on inosine 5'-monophosphate and other purine nucleotides. 再加上,我们可以发5'-Nucleotidase, Cytosolic II 抗体 (57)5'-Nucleotidase, Cytosolic II 试剂盒 (2)和数多这个蛋白质的别的产品。

列出全部蛋白 基因 基因ID UniProt
NT5C2 100363253  
NT5C2 22978 P49902
NT5C2 76952 Q3V1L4

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Insect Cells His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 78至82个工作日
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大肠杆菌(E. Coli) His tag 100 μg Log in to see 33至41个工作日
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NT5C2 蛋白 by Origin and Source

Origin 在表达 标记
Rat (Rattus)
Human , , ,
, , ,
Mouse (Murine) ,

引用最多的5'-Nucleotidase, Cytosolic II 蛋白

  1. Human NT5C2 Protein expressed in Escherichia coli (E. coli) - ABIN667570 : Oka, Matsumoto, Hosokawa, Inoue: Molecular cloning of human cytosolic purine 5'-nucleotidase. in Biochemical and biophysical research communications 1995 (PubMed)
    Show all 2 references for 667570

更多5'-Nucleotidase, Cytosolic II (NT5C2)互动伙伴

Human 5'-Nucleotidase, Cytosolic II (NT5C2) interaction partners

  1. this study implicates altered neural expression of BORCS7, AS3MT (显示 AS3MT 蛋白), and NT5C2 in susceptibility to schizophrenia arising from genetic variation at the chromosome 10q24 locus

  2. NT5C2 variant rs11191580 conferred susceptibility to schizophrenia and affected the clinical symptoms of schizophrenia in a South Chinese Han population.

  3. The aberrantly spliced NT5C2 showed substantial reduction in expression level in the in-vitro study, indicating marked instability of the mutant NT5C2 protein.

  4. Leukemia Relapse-Associated Mutation of NT5C2 Gene is Rare in de Novo Acute Leukemias and Solid Tumors.

  5. cN-II co-immunoprecipitated both with wild type Ipaf (显示 NLRC4 蛋白) and its LRR domain after transfection with corresponding expression vectors, but not with Ipaf (显示 NLRC4 蛋白) lacking the LRR domain.

  6. Data indicate that type II cytosolic 5'-nucleotidase (显示 NT5E 蛋白) (cN-II) exerts a role in nucleotide and drug metabolism and regulating cell survival.

  7. Four novel body mass index-associated loci near the KCNQ1 (显示 KCNQ1 蛋白)(rs2237892), ALDH2 (显示 ALDH2 蛋白)/MYL2 (显示 MYL2 蛋白) (rs671, rs12229654), ITIH4 (显示 ITIH4 蛋白) (rs2535633) and NT5C2 (rs11191580) genes are identified in East Asian-ancestry populations.

  8. These results suggest that mutations in NT5C2 are associated with the outgrowth of drug-resistant clones in acute lymphoblastic leukemia

  9. results highlight the prominent role of relapse-specific mutations in NT5C2 as a mechanism of resistance to 6-Mercaptopurine and a genetic driver of relapse in acute lymphoblastic leukemia

  10. analysis of Drosophila and human 7-methyl GMP-specific nucleotidases

Mouse (Murine) 5'-Nucleotidase, Cytosolic II (NT5C2) interaction partners

  1. The results on muscles from the NT5C (显示 NT5C 蛋白) knockout mice contradict previous findings where AMP (显示 TMPRSS5 蛋白) levels and AMPK (显示 PRKAA1 蛋白) activity were shown to be modulated by NT5C (显示 NT5C 蛋白) enzymes.

Cow (Bovine) 5'-Nucleotidase, Cytosolic II (NT5C2) interaction partners

  1. mutated three residues that mediate interaction in the first activation site (R144, N154, I152) and three in the second (F127, M436 and H428), and found that ApA and ADP interact with the same site, but the sites for ATP and BPG remain uncertain

蛋白简介5'-Nucleotidase, Cytosolic II (NT5C2)

蛋白简介

This gene encodes a hydrolase that serves as an important role in cellular purine metabolism by acting primarily on inosine 5'-monophosphate and other purine nucleotides.

Gene names and symbols associated with NT5C2

  • 5'-nucleotidase, cytosolic IIa (nt5c2a)
  • 5'-nucleotidase, cytosolic II (NT5C2)
  • 5'-nucleotidase, cytosolic II (nt5c2)
  • 5'-nucleotidase, cytosolic II (surE2)
  • 5'-nucleotidase, cytosolic II (LOC100363253)
  • 5'-nucleotidase, cytosolic II (Nt5c2)
  • 2010002I23Rik 蛋白
  • cN-II 蛋白
  • CnII 蛋白
  • ENSMUSG00000025039 蛋白
  • Gm9751 蛋白
  • Gmp 蛋白
  • Nt5b 蛋白
  • NT5C2 蛋白
  • Pnt5 蛋白
  • wu:fc36f11 蛋白
  • wu:fc45b10 蛋白

Protein level used designations for NT5C2

5'-nucleotidase, cytosolic II , fc36f11 , cytosolic 5'-nucleotidase II , cytosolic purine 5'-nucleotidase , cytosolic purine 5'-nucleotidase-like , 5'-nucleotidase (purine), cytosolic type B , IMP-specific 5'-NT , purine 5' nucleotidase , 5'-nucleotidase cytosolic II , cytosolic IMP/GMP-specific 5'-nucleotidase

GENE ID SPECIES
324845 Danio rerio
450706 Pan troglodytes
548490 Xenopus (Silurana) tropicalis
714292 Macaca mulatta
5808749 Sorangium cellulosum So ce56
100172749 Pongo abelii
100363253 Rattus norvegicus
100402763 Callithrix jacchus
22978 Homo sapiens
76952 Mus musculus
294016 Rattus norvegicus
477809 Canis lupus familiaris
281951 Bos taurus
423871 Gallus gallus
444729 Xenopus laevis
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