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NT5C2 encodes a hydrolase that serves as an important role in cellular purine metabolism by acting primarily on inosine 5'-monophosphate and other purine nucleotides. 再加上，我们可以发5'-Nucleotidase, Cytosolic II 抗体 (56) 和 5'-Nucleotidase, Cytosolic II 试剂盒 (3)和数多这个蛋白质的别的产品。
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acute lymphoblastic leukemia-specific mutations affect regulation of cN-II
this study implicates altered neural expression of BORCS7, AS3MT (显示 AS3MT 蛋白), and NT5C2 in susceptibility to schizophrenia arising from genetic variation at the chromosome 10q24 locus
NT5C2 variant rs11191580 conferred susceptibility to schizophrenia and affected the clinical symptoms of schizophrenia in a South Chinese Han population.
The aberrantly spliced NT5C2 showed substantial reduction in expression level in the in-vitro study, indicating marked instability of the mutant NT5C2 protein.
Leukemia Relapse-Associated Mutation of NT5C2 Gene is Rare in de Novo Acute Leukemias and Solid Tumors.
cN-II co-immunoprecipitated both with wild type Ipaf (显示 NLRC4 蛋白) and its LRR domain after transfection with corresponding expression vectors, but not with Ipaf (显示 NLRC4 蛋白) lacking the LRR domain.
Data indicate that type II cytosolic 5'-nucleotidase (显示 NT5E 蛋白) (cN-II) exerts a role in nucleotide and drug metabolism and regulating cell survival.
Four novel body mass index-associated loci near the KCNQ1 (显示 KCNQ1 蛋白)(rs2237892), ALDH2 (显示 ALDH2 蛋白)/MYL2 (显示 MYL2 蛋白) (rs671, rs12229654), ITIH4 (显示 ITIH4 蛋白) (rs2535633) and NT5C2 (rs11191580) genes are identified in East Asian-ancestry populations.
These results suggest that mutations in NT5C2 are associated with the outgrowth of drug-resistant clones in acute lymphoblastic leukemia
results highlight the prominent role of relapse-specific mutations in NT5C2 as a mechanism of resistance to 6-Mercaptopurine and a genetic driver of relapse in acute lymphoblastic leukemia
The results on muscles from the NT5C (显示 NT5C 蛋白) knockout mice contradict previous findings where AMP (显示 TMPRSS5 蛋白) levels and AMPK (显示 PRKAA1 蛋白) activity were shown to be modulated by NT5C (显示 NT5C 蛋白) enzymes.
mutated three residues that mediate interaction in the first activation site (R144, N154, I152) and three in the second (F127, M436 and H428), and found that ApA and ADP interact with the same site, but the sites for ATP and BPG remain uncertain
This gene encodes a hydrolase that serves as an important role in cellular purine metabolism by acting primarily on inosine 5'-monophosphate and other purine nucleotides.
cytosolic 5'-nucleotidase II
, cytosolic purine 5'-nucleotidase
, 5'-nucleotidase, cytosolic II
, 5'-nucleotidase (purine), cytosolic type B
, IMP-specific 5'-NT
, purine 5' nucleotidase
, 5'-nucleotidase cytosolic II
, cytosolic IMP/GMP-specific 5'-nucleotidase
, cytosolic purine 5'-nucleotidase-like